Treatment of children With antidepressants: Focus on selective serotonin reuptake inhibitors

Weinberg, Warren A.; Mayes, Taryn L.

doi:10.1002/(sici)1520-6394(1998)8:1+<13::aid-da3>3.0.co;2-x

Cited by 18 publications

(6 citation statements)

References 30 publications

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“…The presence of comorbidity between these two disorders is important because anxiety and depressive disorders independently contribute to a significant portion of the global burden of disease, with depression being the second largest contributor to years lived with disability in those 15–44 years of age (Ferrari et al, 2013). In addition, comorbidity between mood and anxiety disorders is associated with greater symptom severity (Bernstein, 1991; Coryell et al, 1988), increased substance use, and suicidal risk (Lewinsohn, Gotlib, et al, 1995; Lewinsohn, Rohde, et al, 1995; Rohde et al, 2001), and treatment resistance compared with those who have either disease in isolation (Brent et al, 1998; Emslie et al, 1998; Lewinsohn, Gotlib, et al, 1995; Melton et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Co‐morbidity between mood and anxiety disorders: A systematic review and meta‐analysis

Saha

Lim

Cannon

et al. 2020

Depression and Anxiety

106

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There is consistent evidence that mood disorders often co-occur with anxiety disorders, however, the strength of the association of these two broad groups of disorders has been challenging to summarize across different studies. The aim was to conduct a metaanalysis of publications reporting on the pairwise comorbidity between mood and anxiety disorders after sorting into comparable study types. We searched MEDLINE, Embase, CINAHL, Web of Science, and the grey literature for publications between 1980 and 2017 regardless of geographical locations and languages. We meta-analyzed estimates from original articles after sorting by: (a) broad or narrow diagnostic criteria, (b) study time-frame, and (c) estimates with or without covariate adjustments. Over 43 000 unique studies were identified through electronic searches, of which 391 were selected for fulltext review. Finally, 171 studies were eligible for inclusion, including 53 articles from additional snowball searching. In general, regardless of variations in diagnosis type, study time-frame, temporal order, or use of adjustments, there was substantial comorbidity between mood and anxiety disorders. Based on the entire 90 separate meta-analyses, the median OR was 6.1 (range 1.5-18.7). Of these estimates, all 90 were above 1, and 87 were significantly greater than 1 (i.e., the 95% confidence intervals did not include 1). Fourteen of the 90 pooled estimates had ORs that were greater than 10. This systematic review found robust and consistent evidence of comorbidity between broadly defined mood and anxiety disorders. Clinicians should be vigilant for the prompt identification and treatment of this common type of comorbidity.

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Section: Introductionmentioning

confidence: 99%

Co‐morbidity between mood and anxiety disorders: A systematic review and meta‐analysis

Saha

Lim

Cannon

et al. 2020

Depression and Anxiety

106

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“…1998), higher medical costs (Marciniak et al . 2005), and an increased risk of recurrence (Emslie et al . 1998).…”

Section: Introductionmentioning

confidence: 99%

“…Compared to non-co-morbid presentations of the disorders, co-morbid MDD–ANX is associated with greater symptom severity (Coryell et al 1988; Mitchell et al 1988; Bernstein, 1991), higher rates of suicidal behavior (Reich et al 1993; Lewinsohn et al 1995; Rohde et al 2001), higher rates of mental health treatment utilization but poorer treatment response (Lewinsohn et al 1995; Brent et al 1998; Emslie et al 1998), higher medical costs (Marciniak et al 2005), and an increased risk of recurrence (Emslie et al 1998). Given the high level of overlap between MDD and ANX, and the severe impairment and cost incurred by their co-morbidity, understanding the development of co-morbid MDD–ANX represents a pressing need.…”

Section: Introductionmentioning

confidence: 99%

Co-morbidity between major depressive disorder and anxiety disorders: shared etiology or direct causation?

et al. 2011

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Background Major depressive disorder (MDD) and anxiety disorders (ANX) are debilitating and prevalent conditions that often co-occur in adolescence and young adulthood. The leading theoretical models of their co-morbidity include the direct causation model and the shared etiology model. The present study compared these etiological models of MDD–ANX co-morbidity in a large, prospective, non-clinical sample of adolescents tracked through age 30. Method Logistic regression was used to examine cross-sectional associations between ANX and MDD at Time 1 (T1). In prospective analyses, Cox proportional hazards models were used to examine T1 predictors of subsequent disorder onset, including risk factors specific to each disorder or common to both disorders. Prospective predictive effect of a lifetime history of one disorder (e.g. MDD) on the subsequent onset of the second disorder (e.g. ANX) was then examined. This step was repeated while controlling for common risk factors. Results The findings supported relatively distinct profiles of risk between MDD and ANX depending on order of development. Whereas the shared etiology model best explained co-morbid cases in which MDD preceded ANX, direct causation was supported for co-morbid cases in which ANX preceded MDD. Conclusions Consistent with previous research, significant cross-sectional and prospective associations were found between MDD and ANX. The results of the present study suggest that different etiological models may characterize the co-morbidity between MDD and ANX based upon the temporal order of onset. Implications for classification and prevention efforts are discussed.

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“…Using the MINI to support the clinician in detecting comorbid psychopathology can improve treatment and thereby prognosis in mood and anxiety disorders. Previous studies have shown poorer response to treatment (Brent et al, 1998;Emslie et al, 1998;Lewinsohn et al, 1995) and an increased risk of recurrence (Emslie et al, 1998) in those with comorbid disorders. In addition to the primary diagnosis being assessed correctly, detection of comorbidity seems therefore of high clinical relevance in order to adjust treatment choice (Newman et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Agreement between clinical and MINI diagnoses in outpatients with mood and anxiety disorders

Verhoeven

Swaab

Carlier

et al. 2017

Journal of Affective Disorders

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Treatment of children With antidepressants: Focus on selective serotonin reuptake inhibitors

Cited by 18 publications

References 30 publications

Co‐morbidity between mood and anxiety disorders: A systematic review and meta‐analysis

Co‐morbidity between mood and anxiety disorders: A systematic review and meta‐analysis

Co-morbidity between major depressive disorder and anxiety disorders: shared etiology or direct causation?

Agreement between clinical and MINI diagnoses in outpatients with mood and anxiety disorders

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