Treatment of Chronic Bone Infections Using the Collagen Based Haemostatic - Collatamp G

Abstract

Treating chronic bone infection is challenging, requiring complete excision of the affected areas and antimicrobial therapy. Acquiring active concentrations of antibiotics is difficult, as well as filling up bone defects resulting from sequestrectomy, and very few methods of treatment address both issues simultaneously. The authors describe the clinical results after using Collatamp G, a collagen-based, antibiotic filled sponge with two actions: local delivery of high antibiotic doses without systemic side effects and enhancement of healing due to collagen, thus covering the bone defect without any further osteoplastic surgery. This paper thus identifies Collatamp G as a biomaterial able to solve the above mentioned problems in treating bone infections.Keywords: bone infections, collagen matrix, gentamicine, antibiotic delivery

Current research progress of local drug delivery systems based on biodegradable polymers in treating chronic osteomyelitis

“…In addition, Collatamp G, as one kind of GCCI, is a collagen-based sponge consisting of 280 mg collagen and 200 mg gentamicin, showing high treatment efficiency in post-traumatic bone infections ( Deshmukh et al, 2016 ). Lupescu et al (2016) described the clinical results after using Collatamp G, and the results are shown in Figure 1 . The positive outcome for bone healing and infection control suggests that Collatamp G is a biomaterial that can address the abovementioned issues in treating bone infections.…”

“… Open fracture of the proximal tibial metaphysis (A) , massive soft tissue injuries, periosteal stripping (B) , external fixator with knee spanning, bone defect visible (C) , Collatamp G filling the bone defect (D) , remaining skin defect, secondary epitelisation (E) . Reproduced with permission from Lupescu et al (2016) . Copyright Trans Tech Publications Ltd. …”