Treatment of Chronic Enterovirus Encephalitis With Fluoxetine in a Patient With X-Linked Agammaglobulinemia

Gofshteyn, Jacqueline S.; Cárdenas, Ana Marı́a; Bearden, David

doi:10.1016/j.pediatrneurol.2016.06.014

Cited by 44 publications

(44 citation statements)

References 19 publications

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“…Also, itraconazole and fluoxetine showed anti-Enterovirus properties in vitro, and successful treatment of chronic enteroviral meningitis with fluoxetine has been reported in a XLA patient [2,24]. Antiviral effects of immunosuppressive regimens in transplanted and other immunodeficient patients have been reported, specifically the anti-Cytomegalovirus and anti-Norovirus efficacy of the mTOR (mechanistic target of rapamiycin) inhibitors sirolimus and everolimus [5,[25][26][27].…”

Section: Furthermore His Memory Cd8 + T Cells Displayed Increased Exmentioning

confidence: 99%

Chronic Aichi Virus Infection in a Patient with X-Linked Agammaglobulinemia

et al. 2018

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Section: Furthermore His Memory Cd8 + T Cells Displayed Increased Exmentioning

confidence: 99%

Chronic Aichi Virus Infection in a Patient with X-Linked Agammaglobulinemia

et al. 2018

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“…[27][28][29] A recent case report describes favorable response to fluoxetine in a patient with X-linked agammaglobulinemia and chronic enterovirus (coxsackie B virus) encephalitis. 30 Fluoxetine has been proposed as a potential therapeutic agent to be investigated in enterovirus-associated cases of AFM. 31 Vigilant supportive care was identified by the CDC recommendations as the mainstay of AFM management.…”

Section: Managementmentioning

confidence: 99%

Acute flaccid myelitis: A clinical review of US cases 2012–2015

Messacar

Schreiner

Haren

et al. 2016

Annals of Neurology

199

301

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This review highlights clinical features of the increasing cases of acute flaccid paralysis associated with anterior myelitis noted in the United States from 2012 to 2015. Acute flaccid myelitis refers to acute flaccid limb weakness with spinal cord gray matter lesions on imaging or evidence of spinal cord motor neuron injury on electrodiagnostic testing. Although some individuals demonstrated improvement in motor weakness and functional deficits, most have residual weakness a year or more after onset. Epidemiological evidence and biological plausibility support an association between enterovirus D68 and the recent increase in acute flaccid myelitis cases in the United States.

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“…So far, 2C ATPase inhibitors have not been tested in clinical trials. However, fluoxetine was effective in an immunocompromised child with chronic enterovirus encephalitis [43 ], implying that 2C ATPase inhibitors have potential for clinical use.…”

Section: C Atpase Inhibitorsmentioning

confidence: 99%

Direct-acting antivirals and host-targeting strategies to combat enterovirus infections

Bauer

Lyoo

Schaar

et al. 2017

Current Opinion in Virology

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Enteroviruses (e.g., poliovirus, enterovirus-A71, coxsackievirus, enterovirus-D68, rhinovirus) include many human pathogens causative of various mild and more severe diseases, especially in young children. Unfortunately, antiviral drugs to treat enterovirus infections have not been approved yet. Over the past decades, several direct-acting inhibitors have been developed, including capsid binders, which block virus entry, and inhibitors of viral enzymes required for genome replication. Capsid binders and protease inhibitors have been clinically evaluated, but failed due to limited efficacy or toxicity issues. As an alternative approach, host-targeting inhibitors with potential broad-spectrum activity have been identified. Furthermore, drug repurposing screens have recently uncovered promising new inhibitors with disparate viral and host targets. Together, these findings raise hope for the development of (broad-range) anti-enteroviral drugs.

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Treatment of Chronic Enterovirus Encephalitis With Fluoxetine in a Patient With X-Linked Agammaglobulinemia

Cited by 44 publications

References 19 publications

Chronic Aichi Virus Infection in a Patient with X-Linked Agammaglobulinemia

Chronic Aichi Virus Infection in a Patient with X-Linked Agammaglobulinemia

Acute flaccid myelitis: A clinical review of US cases 2012–2015

Direct-acting antivirals and host-targeting strategies to combat enterovirus infections

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