Treatment of Chronic Prostatitis and Prostatodynia with Pollen Extract

Buck, A. C.; Rees, R. W. M.; Ebeling, L.

doi:10.1111/j.1464-410x.1989.tb05285.x

Cited by 58 publications

(28 citation statements)

References 5 publications

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“…9) Extracts of bee pollen are thought to be effective in the treatment of prostatic conditions due to their presumed anti-inflammatory and anti-androgenic effects. 10,11) The high reactivity of most free radicals makes their detection difficult. ESR is a spectroscopic technique that can detect the unpaired electron present in a free radical.…”

mentioning

confidence: 99%

1,1-Diphenyl-2-picrylhydrazyl Radical Scavenging Activity of Bee Products and Their Constituents Determined by ESR

Itoh

Narahara

Shimazawa

et al. 2009

Biological & Pharmaceutical Bulletin

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The aim of this work was to investigate the antioxidant property of honeybee products and their constituents using an ESR method. Antioxidative activity was evaluated as the scavenging activity of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. The DPPH radical scavenging activities, in descending order, were: ethanol extract of Chinese red propolisϾ Ͼethanol extract of Brazilian green propolisϾ Ͼwater extract of Brazilian green propolisϾ Ͼethanol extract of bee pollen. Many natural compounds are included in Brazilian green propolis, such as caffeoylquinic acid derivatives [3,4-di-caffeoylquinic acid (3,4-CQA), 3,5-di-caffeoylquinic acid (3,5-CQA), and chlorogenic acid (ChA)] and cinnamic acid derivatives [artepillin C, baccharin, r r-coumaric acid, and drupanin]. Caffeoylquinic acid derivatives exhibited DPPH radical scavenging activity as strong as that of ascorbic acid and trolox. Among the cinnamic acid derivatives, artepillin C exhibited relatively strong DPPH radical scavenging activity. Caffeic acid phenethyl ester (CAPE), a constituent of Chinese red propolis, exhibited potent DPPH radical scavenging activity, stronger than that of ascorbic acid and trolox. Caffeic acid, a metabolite of caffeoylquinic acid, exhibited powerful DPPH radical scavenging activity, while quinic acid, another metabolite of caffeoylquinic acid, had no such activity. Both Brazilian and Chinese propolis and their constituents (caffeoylquinic acid derivatives and CAPE) therefore appear to be powerful scavengers of DPPH radical, and the effects may be partly dependent on the nature of their caffeoyl groups.

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confidence: 99%

1,1-Diphenyl-2-picrylhydrazyl Radical Scavenging Activity of Bee Products and Their Constituents Determined by ESR

Itoh

Narahara

Shimazawa

et al. 2009

Biological & Pharmaceutical Bulletin

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“…Cernilton,ein Gräserpollenextrakt,hat in 2 Untersuchungen eine deutliche Symptomverbesserung bei etwa 80% der Patienten gezeigt [13,38].…”

Section: Phytotherapieunclassified

Chronische abakterielle Prostatitis

et al. 2004

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“…In these countries, there are about 30 plant-based products available for the treatment of BPH, and many of them contain extract of saw palmetto (Serenoa repens) [61,62]. The other plants normally used include Pygeum africanum, Urtica dioea (stinging nettles), Cucurbita, and Cernilton [63,64]. The effectiveness of the plant products was found to be Serenoa 1 Cernilton 1 Pygeum 1 Urtica.…”

Section: Treatment Of Bphmentioning

confidence: 99%

α-Adrenoceptor Antagonists in the Treatment of Benign Prostate Hyperplasia

Thiyagarajan

2002

Pharmacology

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Benign prostate hyperplasia (BPH) is a common malady affecting elderly men throughout the world, and it is the most common cause of voiding dysfunctions in man. The disease becomes prevalent, as the mean age of the population increases. In BPH the glandular cells and myofibroblasts of periurethral and transition zones proliferate excessively. This excessive growth of tissue mass physically compresses the urethra, leading to urinary obstruction and lower urinary tract symptoms (LUTS). Another major factor that contributes to LUTS in BPH is the increase in smooth muscle tone, a dynamic component. Contraction of the prostate gland is mainly under the control of the autonomic system and is mediated through α-adrenoceptors. In addition to α₁-adrenoceptors, there are many other components that influence growth and contraction of the prostate gland, resulting in the development of BPH and LUTS. The prostate gland is contracted on stimulating 5-HT, endothelin, tachykinin, and muscarinic cholinergic receptors. Growth of the prostate gland is under the control of androgens, endothelin growth factor, vasoactive intestinal peptide, nerve growth factor, and growth hormone. The combination of excessive growth and the tone produced by different components results in LUTS and BPH. α₁-Adrenoceptor antagonists were successfully used in the treatment of BPH to relieve the LUTS. The high selectivity of α_1A-adrenoceptor antagonists reflects the uroselectivity. The uroselective compounds like terazosin, doxazosin, tamsulosin, and alfuzosin are in clinical use. Other new potent uroselective compounds, which are analogs of nigulidipine, 5-methyl-urapidil, or naftopidil, are in clinical trials. In addition to α-antagonists, antiandrogens (5α-reductase inhibitors) and polyherbal formulations are used to treat BPH. The success of BPH treatment lies in the development of new chemical entities which are efficacious as well as more uroselective and hence have least side effects.

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Treatment of Chronic Prostatitis and Prostatodynia with Pollen Extract

Cited by 58 publications

References 5 publications

1,1-Diphenyl-2-picrylhydrazyl Radical Scavenging Activity of Bee Products and Their Constituents Determined by ESR

1,1-Diphenyl-2-picrylhydrazyl Radical Scavenging Activity of Bee Products and Their Constituents Determined by ESR

Chronische abakterielle Prostatitis

α-Adrenoceptor Antagonists in the Treatment of Benign Prostate Hyperplasia

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