Treatment of chronic tennis elbow with botulinum toxin

Morre, H. H. E.; Keizer, Stefan B.; Os, Johannes J van

doi:10.1016/s0140-6736(05)62958-3

Cited by 65 publications

(39 citation statements)

References 2 publications

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“…Refractory cases may respond to surgery. In an open study, Morre et al [26] treated 14 patients with chronic refractory tennis elbow. They injected the fascicles of the extensor digitorum communis to digits three and four with 20 to 40 U of BTX (serotype and brand were not specified, but the authors state the doses were based on another study [27] that used Botox).…”

Section: Tennis Elbowmentioning

confidence: 99%

Botulinum toxin for the treatment of musculoskeletal pain and spasm

Sheean

2002

Current Science Inc

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The impressive pain relief experienced by sufferers of dystonia and spasticity from intramuscular injections of botulinum toxin suggested that patients with other chronic, musculoskeletal pain conditions also may benefit. However, there have been relatively few placebo-controlled studies of botulinum toxin in such non-neurologic conditions as myofascial pain syndrome, chronic neck and low back pain, and fibromyalgia; the results of these studies have not been impressive. One explanation for the lack of positive findings may be the lack of clinically evident muscle spasms (overactivity), despite the presence of muscle tenderness, tightness, or trigger points. Clinical observations of pain relief from injections of botulinum toxin for dystonia and spasticity and its apparent efficacy in treating migraine suggest an anti-nociceptive action independent of its neuromuscular junction-blocking action. Evidence from animal experiments supports this notion, and other data provide plausible physiologic mechanisms in the periphery and central nervous systems. These involve modulation of the activity of the neurotransmitters glutamate, substance P, calcitonin gene-related peptide, enkephalins, and others. However, even if botulinum toxin is firmly established as an analgesic, there is insufficient clinical evidence of its efficacy in treating non-neurologic, chronic, musculoskeletal pain conditions.

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Section: Tennis Elbowmentioning

confidence: 99%

Botulinum toxin for the treatment of musculoskeletal pain and spasm

Sheean

2002

Current Science Inc

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“…Speziell bei der Epikondylitis zeigten sich erste positive Ergebnisse [29]. Keizer et al [22] verglichen in einer randomisierten Studie bei 40 Patienten BTX A-Infiltrationen versus chirurgische Verfahren.…”

Section: Diagnostikunclassified

Konservative und operative Therapie der Epikondylitiden

Jerosch

2008

Obere Extremität

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EpidemiologieDas Krankheitsbild der Epikondylopathia humeri radialis wurde bereits von Runge im Jahre 1873 als Schreibkrampf beschrieben [41]. Der Terminus "Tennis-Ellenbogen" hat sich zwar vielerorts eingebürgert, ist aber nicht zutreffend, da deutlich weniger als 50 Prozent aller als Epikondylopathia humeri radialis oder lateralis be- Jörg JeroschKonservative und operative Therapie der Epikondylitiden

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“…Ein erster Therapieversuch bei 14 Patienten mit Tennisellenbogen wurde 1997 von Morré et al veröffentlicht [16]. Die Ergebnisse waren vielversprechend und wurden in einer weiteren Studie dieser Arbeitsgruppe bestätigt [11].…”

Section: Studienzielunclassified

“…Unsere Ergebnisse stimmen tendenziell mit den Ergebnissen der einzigen bis zum Studienbeginn veröf-fentlichten Untersuchungen der Gruppe Morré, Keizer et al überein [11,16]. Unterschiede bestehen neben dem Abb.…”

Section: Diskussionunclassified