Treatment of chronic wounds with methylene blue photodynamic therapy: A case report

Winyk, Ana Paula; Santos, Fernando Sluchensci dos; Queiroz, Erika Fernanda; Soares, Kelly Cristina Nogueira; Caetano, Wilker; Tominaga, Tânia Toyomi

doi:10.1016/j.pdpdt.2022.103016

Cited by 13 publications

(4 citation statements)

References 5 publications

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“…Recently, there have been two reports about low‐dose methylene blue (MB)‐mediated PDT for the treatment of lower extremity ulcers (including diabetic foot ulcers, venous leg ulcers and pressure ulcers) with satisfactory therapeutic effect. The light wavelength is in the red light band (650 nm and 660 nm), and the energy density is 3.8 J/cm 2 and 6 J/cm 2 respectively [82, 83]. These studies illustrate the beneficial effects of low‐dose PDT on wound healing.…”

Section: Low‐dose Ala/mal‐pdt In Wound Healingmentioning

confidence: 99%

Positive effects of low‐dose photodynamic therapy with aminolevulinic acid or its methyl ester in skin rejuvenation and wound healing: An update

Zhang

Liu

Wang

2023

Journal of Biophotonics

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In dermatology, photodynamic therapy (PDT) is widely used in skin tumors, infections, etc., because of the killing effect triggered by toxic reactive oxygen species (ROS). However, the ROS concentration is determined by various photosensitizer concentrations and formulations, as well as various irradiation parameters. Low‐dose PDT leads to sufficiently low ROS level, which results in biological effects that are the exact opposite of the killing potency. Therefore, in recent years, low‐dose PDT has been exploited in improving aging and wound. Low‐dose ALA/MAL PDT might improve aging through promoting the proliferation of fibroblasts, blocking DNA damage, counteracting oxidative stress, inhibiting melanogenesis, and remodeling lymphatic vessels in aged skin. Promoting fibroblasts and epidermal stem cells proliferation and migration, promoting granulation tissue formation and angiogenesis and regulating the inflammatory process might be the mechanisms of low‐dose ALA/MAL PDT in wound healing. Nevertheless, the positive effects of low‐dose PDT have not been thoroughly investigated in dermatology, and high‐quality studies are still needed to fill the relevant vacancy.

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Section: Low‐dose Ala/mal‐pdt In Wound Healingmentioning

confidence: 99%

Positive effects of low‐dose photodynamic therapy with aminolevulinic acid or its methyl ester in skin rejuvenation and wound healing: An update

Zhang

Liu

Wang

2023

Journal of Biophotonics

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“…A variety of photosensitizing agents are discussed for PDT use at different concentrations with different incubation periods, irradiation doses, and wavelengths: chlorinebased (phenothiazine chlorine, meso-tetra-hydroxyphenyl-chlorin (mTHPC), fotoditazin alone and in complexes, polyethylenimine-chlorine p6 (PEI-ce6), poly-lysine-conjugated chlorine p6 (pl-cp6)); methylene blue (MB); toluidine blue; indocyanine green (ICG); 5aminolevulinic acid (5-ALA); methyl-aminolevulinate (MAL); pyropheophorbide-a; 3,7bis (N, N-dibutyl-amino) phenothiazin-5-ium bromide; Rose Bengal; toluidine-O (TBO); methoxypolyethylene glycol-pheophorbide a (mPEG-Pba), and others [18,23,25,[34][35][36].…”

Section: Photosensitizing Agents For Pdt For Antibiotic-resistant Mic...mentioning

confidence: 99%

Photodynamic Therapy under Diagnostic Control of Wounds with Antibiotic-Resistant Microflora

Shiryaev,

Ivankov,

Voitova

et al. 2024

Photonics

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Background: Difficulties in the treatment of purulent wounds are caused by bacterial biofilms, which results in decontamination limitations. Infected wounds are not sufficiently susceptible to existing antibiotics, necessitating the search for alternative approaches to reduce the concentration of pathogenic microflora. Methods: This study describes an approach to the effective treatment of wounds by photodynamic inactivation or therapy (PDI/PDT) of antibiotic-resistant microflora under fluorescence control. For this purpose, laser and LED light (660–680 nm) and different groups of photosensitizers (PS) (1% solutions of methylene blue, aluminum phthalocyanine, chlorine e6 and nanocomposites containing these groups of PS) were used. The study included 90 patients with various wounds. Some patients were subjected to fluorescence diagnosis by laser spectral analysis before the PDT. Results: Positive results were achieved in 76 patients (84%, p < 0.05). After the first PDT session, a decrease in the concentration of microflora was noticeable. By the third and seventh days, a significant to complete inactivation of bacteria was obtained. In all patients who were photo-diagnosed before PDT, a significant PS concentration decrease of more than 75% after PDT was obtained. Conclusion: PDT is an effective method for the inactivation of antibiotic-resistant pathogens, including in long non-healing wounds, contributing also to early tissue regeneration.

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“…The use of methylene blue PDT has been explored in various small-scale case studies. These studies have found methylene blue to be an effective photosensitizer to treat infected chronic wounds without adverse side effects [ 54 , 55 , 56 , 57 ]. Larger-scale studies with proper controls would help strengthen these conclusions.…”

Section: Photodynamic Therapymentioning

confidence: 99%

Photodynamic Therapy, Probiotics, Acetic Acid, and Essential Oil in the Treatment of Chronic Wounds Infected with Pseudomonas aeruginosa

Chin,

Zhao,

Mayberry

et al. 2023

Pharmaceutics

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As a prevalent medical problem that burdens millions of patients across the world, chronic wounds pose a challenge to the healthcare system. These wounds, often existing as a comorbidity, are vulnerable to infections. Consequently, infections hinder the healing process and complicate clinical management and treatment. While antibiotic drugs remain a popular treatment for infected chronic wounds, the recent rise of antibiotic-resistant strains has hastened the need for alternative treatments. Future impacts of chronic wounds are likely to increase with aging populations and growing obesity rates. With the need for more effective novel treatments, promising research into various wound therapies has seen an increased demand. This review summarizes photodynamic therapy, probiotics, acetic acid, and essential oil studies as developing antibiotic-free treatments for chronic wounds infected with Pseudomonas aeruginosa. Clinicians may find this review informative by gaining a better understanding of the state of current research into various antibiotic-free treatments. Furthermore. this review provides clinical significance, as clinicians may seek to implement photodynamic therapy, probiotics, acetic acid, or essential oils into their own practice.

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Treatment of chronic wounds with methylene blue photodynamic therapy: A case report

Cited by 13 publications

References 5 publications

Positive effects of low‐dose photodynamic therapy with aminolevulinic acid or its methyl ester in skin rejuvenation and wound healing: An update

Positive effects of low‐dose photodynamic therapy with aminolevulinic acid or its methyl ester in skin rejuvenation and wound healing: An update

Photodynamic Therapy under Diagnostic Control of Wounds with Antibiotic-Resistant Microflora

Photodynamic Therapy, Probiotics, Acetic Acid, and Essential Oil in the Treatment of Chronic Wounds Infected with Pseudomonas aeruginosa

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