Treatment of Coagulation and Platelet Disorders

Brainard, Benjamin M.

doi:10.1002/9781119421375.ch20

Cited by 2 publications

(4 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Treatments for bleeding disorders have experienced strong development in veterinary medicine, especially with the arrival of new drugs and an easier access to some molecules for veterinarians. A hypercoagulable state is usually treated with oral antiplatelet agents: aspirin and clopidogrel [ 107 ]. Even if they are generally very well tolerated, these molecules irreversibly inhibit platelet function.…”

Section: Therapeutic Applications In Veterinary Medicinementioning

confidence: 99%

“…Finally, there are few veterinary fibrinolytic molecules. These are mainly streptokinase and tissue plasminogen activator, both very rarely used in practice because they are not very accessible, with potentially major side effects and little demonstrated benefit [ 107 ]. Developing aptamers with better fibrinolytic efficiency could, for example, make it possible to treat cats suffering from aortic thromboembolism, still too often a reason for euthanasia.…”

Section: Therapeutic Applications In Veterinary Medicinementioning

confidence: 99%

See 1 more Smart Citation

Potential applications of aptamers in veterinary science

Niederlender

Fontaine

Karadjian

2021

Vet Res

View full text Add to dashboard Cite

Aptamers are small nucleic acids that fold in a three-dimensional conformation allowing them to bind specifically to a target. This target can be an organic molecule, free or carried in cells or tissues, or inorganic components, such as metal ions. Analogous to monoclonal antibodies, aptamers however have certain advantages over the latter: e.g., high specificity for their target, no to low immunogenicity and easy in vitro selection. Since their discovery more than 30 years ago, aptamers have led to various applications, although mainly restricted to basic research. This work reviews the applications of aptamers in veterinary science to date. First, we present aptamers, how they are selected and their properties, then we give examples of applications in food and environmental safety, as well as in diagnosis and medical treatment in the field of veterinary medicine. Because examples of applications in veterinary medicine are scarce, we explore the potential avenues for future applications based on discoveries made in human medicine. Aptamers may offer new possibilities for veterinarians to diagnose certain diseases—particularly infectious diseases—more rapidly or “at the patient’s bedside”. All the examples highlight the growing interest in aptamers and the premises of a potential market. Aptamers may benefit animals as well as their owners, breeders and even public health in a “One Health” approach.

show abstract

Section: Therapeutic Applications In Veterinary Medicinementioning

confidence: 99%

Section: Therapeutic Applications In Veterinary Medicinementioning

confidence: 99%

Potential applications of aptamers in veterinary science

Niederlender

Fontaine

Karadjian

2021

Vet Res

View full text Add to dashboard Cite

show abstract

“…Hemen ardından uygun çaptaki endotrakeal tüplerle entübasyon gerçekleştirildi. Protrombin zamanı (PT), başlangıç doku faktörleri ve fosfolipid kombinasyonu için kullanılır ve primer olarak ekstrinsik ve ortak koagülasyon yolunu değerlendirmek için ölçülür (Brainard, 2015). Bu testte plazman kalsiyum ve protromboplastin (doku faktörü)…”

Section: Anestezi Protokolüunclassified

“…Ekstrinsik yolda (Yılmaz, 2000). Trombin zamanı kan fibrinojen düzeyine bağlıdır ve ortak yolda sadece fibrin oluşumuyla ölçülür (Brainard, 2015). Van…”

Section: Anestezi Protokolüunclassified

Köpeklerde Midazolam-Ketamin-İzofloran ve Midazolam-Propofol-İzofloran Anestezisinin Koagulasyon Parametrelerine Etkisinin Araştırılması

Arca¹,

Saritaş²

2017

Mehmet Akif Ersoy Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi

View full text Add to dashboard Cite

The aim of this study was to evaluate the effects of Midazolam-Ketamine-Isoflorane (MKİ) ve Midazolam-Propofol-Isoflorane (MPİ) anesthesia on coagulation parameters, vital parameters, hemogram parameters, blood gas parameters and biochemical parameters. The study was held on varying breed, race and gendered total 20 dogs aging between 4 months to 6 years that were brought for various reasons taken under surgical intervention to Afyon Kocatepe University animal Hospital. Dogs were randomly grouped as MKI (n=10) and MPI (n=10). MKI and MPI groups dogs were premedicated with midazolam 0,2-0,4 mg/kg intravenously following fasting period for 12 hours. MKI group anesthesia were induced by the injection of ketamine 15mg/kg and in MPI group by the slow injection of propofol 6-7 mg/kg by i.v. Both group dogs were intubated with endotracheal tube and general anaesthesi was achieved by Isoflurane 2%. Blood samples were collected from all group dogs at 0 th , 15. th And 30 th minutes and postoperatively 0 th min. and 6 th hour for the measurement of hemogram blood gases and coagulation parameters together with the collection of vital parameters. When the groups were compared, preoperative 0 th minute measurements PT, TT fibrinogen and APTT values were insinificantly changed statistically (p>0.05). All the time period measurements were found between normal values. Within the results of measurements, both anesthesia protocol was found safe and convenient in the use of dogs' anesthesia for the mean of coagulation parameters, vital parameters, blood gas parameters hemogram parameters and biochemical parameters. Öz: Bu çalışmanın amacı, köpeklerde Midazolam-Ketamin-İzofloran (MKİ) ve Midazolam-Propofol-İzofloran (MPİ) anestezisinin koagülasyon parametreleri, vital parametreler, hemogram parametreleri, kan gazı parametreleri, biyokimyasal parametreler üzerindeki etkisinin araştırılmasıdır. Çalışmada, Afyon Kocatepe Üniversitesi Veteriner Sağlık Uygulama ve Araştırma Merkezine çeşitli operasyonlar yapılması amacıyla getirilen, farklı ırktan, farklı cinsiyetten ve yaşları 4 ay ile 6 yaş arası değişen 20 adet köpek kullanıldı. Köpekler rastgele (MKİ n=10) ve (MPİ n=10) iki gruba ayrıldı. MKİ protokolü uygulanan köpeklerde 12 saat açlığı takiben Preanestezik olarak midazolam 0,2-0,4 mg/kg dozda intravenöz yolla uygulandı. Anestezi indüksiyonu Ketamin HCl'ün 15 mg/kg dozda intravenöz uygulanmasıyla sağlandı. MPİ protokolü uygulanan köpeklerde 12 saat açlığı takiben preanestezik olarak midazolam 0,2-0,4 mg/kg dozda intravenöz kullanıldı. Anestezi indüksiyonu; propofol solüsyonunun 6-7 mg/kg dozda intravenöz yolla yavaş şekilde enjekte edilmesiyle sağlandı. Hemen ardından iki gruptaki köpeklere uygun çaptaki endotrakeal tüplerle entübasyon gerçekleştirildi ve genel anestezi %2 izofluran ile sağlandı. Gruplar karşılaştırıldığında preoperatif 0. dakika ölçümlerine göre tüm ölçüm zamanlarında PT, TT, Fibrinojen ve APTT değerlerinde istatistiksel önemi olmayan (p>0.05) değişim kaydedildi ve tüm ölçüm zamanlarındaki bulgular referans aralıkt...

show abstract

Treatment of Coagulation and Platelet Disorders

Cited by 2 publications

References 61 publications

Potential applications of aptamers in veterinary science

Potential applications of aptamers in veterinary science

Köpeklerde Midazolam-Ketamin-İzofloran ve Midazolam-Propofol-İzofloran Anestezisinin Koagulasyon Parametrelerine Etkisinin Araştırılması

Contact Info

Product

Resources

About