Treatment of Common Warts with an Intralesional Mixture of 5-Fluorouracil, Lidocaine, and Epinephrine

Yazdanfar, Ameneh; Fereydoonnejad, Morteza; Farshchian, Mehdi

doi:10.1097/00042728-200805000-00009

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…Yazdanfar, Farshchian, Fereydoonnejad, and Farshchian () used intralesional 5‐FU in the same dosing schedule to treat common warts. Complete response was observed in 64.7% of warts treated with 5‐FU group compared to 35.3% in the warts treated with placebo ( p < .05).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of intralesional methotrexate in the treatment of plantar warts

Abdo

Elrewiny

Elkholy³

et al. 2020

Dermatologic Therapy

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Warts are tumors or growths caused by infection with human papilloma virus (HPV). Currently, over 170 HPV types have been identified. This study aimed to evaluate the efficacy and safety of intralesional injection of methotrexate (MTX) for the treatment of plantar warts. Sixty patients presented with plantar warts were divided into two groups. Group A patients were injected with intralesional MTX (2 mg/ml). Group B patients were injected with intralesional saline as a placebo. The injections were repeated every week for a maximum of six sessions or until complete clearance, whichever was earlier. The patients were followed up for 6 months after the last injection. In the intralesional MTX group, 2 patients (6.7%) showed complete improvement, 8 patients (26.7%) showed partial improvement, and 20 patients (66.7%) showed no improvement. In the intralesional saline group, 3 patients (10%) showed complete improvement, 4 patients (13.3%) showed partial improvement, and 23 patients (76.7%) showed no improvement. Reported adverse events were local reactions in the form of swelling, pain, and infection in both groups. There was no statistically significant difference between the therapeutic responses to intralesional MTX injection and saline.

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Section: Discussionmentioning

confidence: 99%

Efficacy of intralesional methotrexate in the treatment of plantar warts

Abdo

Elrewiny

Elkholy³

et al. 2020

Dermatologic Therapy

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“…5-FU exerts its effects on warts by disrupting viral DNA synthesis. Two RCTs evaluated the efficacy of intralesional 5-FU and local anesthesia (4 mL of 50 mg/mL 5-FU, 1 mL of a mixture of 20 mg/mL lidocaine, and 0.0125 mg/mL epinephrine), comparing it with saline injection with the successful treatment of 65% of the warts [19,20]. However, an RCT reported that combining topical 5-FU with cryotherapy had no additional benefit when compared to cryotherapy alone [21].…”

Section: Efficacymentioning

confidence: 99%

Clinical Efficacy of 5-Fluorouracil and Bleomycin in Dermatology

Kim,

Woo,

Cho

et al. 2024

JCM

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Bleomycin and 5-fluorouracil (5-FU) are widely used in various dermatological disorders. Both drugs are well-recognized as antineoplastic drugs and exert their effect by blocking the cell cycle. Topical and intralesional formulations are available and have been studied in both non-neoplastic and cancerous lesions. However, data comparing the effect of bleomycin and 5-FU in the dermatological disorders are limited. This review outlines the action mechanisms of both drugs and compares their clinical efficacies in a wide range of dermatologic diseases including hypertrophic scar, wart, skin cancer, vascular malformation, hemangioma, and vitiligo, and discusses the overall safety of the drugs. Intralesional bleomycin treatment is effective in hypertrophic scars and warts, but intralesional 5-FU may also be considered since it is cheaper and less painful. Moreover, intralesional 5-FU and bleomycin injection is a viable option for premalignant lesions (i.e., actinic keratosis) and inoperable skin cancers. Both bleomycin and 5-FU have been applied as treatment adjuncts for vitiligo, with 5-FU showing a slightly better outcome. Both agents have a good safety profile, and no serious side effects have been reported following their use in the field of dermatology.

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Treatment of Common Warts with an Intralesional Mixture of 5-Fluorouracil, Lidocaine, and Epinephrine

Cited by 2 publications

References 15 publications

Efficacy of intralesional methotrexate in the treatment of plantar warts

Efficacy of intralesional methotrexate in the treatment of plantar warts

Clinical Efficacy of 5-Fluorouracil and Bleomycin in Dermatology

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