Treatment of community-associated methicillin-resistant Staphylococcus aureus

Abstract

Methicillin-resistant Staphylococcus aureus has emerged in the community among patient populations without traditional antibiotic resistance risk factors and is causing a variety of clinical syndromes, in particular skin and soft tissue infections. These infections can range from minor skin involvement that can be treated in an outpatient setting to more serious infections such as necrotizing fasciitis requiring hospitalization. Inpatient and outpatient healthcare providers must be aware of the treatment, prevention, and infection control practices for this emerging pathogen.

Incidence and characterization of Staphylococcus aureus in fishery products marketed in Galicia (Northwest Spain)

“…The emergence of multi-drug resistant pathogens is recognized as an environmental hazard to the food supply and human health, as it makes eradication more difficult and incidence to increase (Livermore, 2000;Popovich et al, 2007;Ribeiro et al, 2007). S. aureus has developed multidrug resistance worldwide, but wide variations in incidence exist regionally (Gündogân et al, 2006;Normanno et al 2007;Peles et al, 2007;Pesavento et al, 2007).…”

“…Methicillin-resistant S. aureus (MRSA) are being increasingly found outside clinical settings (Popovich et al, 2007;Ribeiro et al, 2007;Stankovic et al, 2007). MRSA have thus been found in food animals (Lee, 2003) and different foods (Gündogân et al, 2006;Peles et al, 2007;Pereira et al, 2009;Pesavento et al, 2007) and also in fishery products recently (Beleneva, 2011).…”

“…Multi-resistant S. aureus is rather common in hospital settings and farms (Livermore, 2000;Sakoulas and Moellering, 2008). Community-associated multi-resistant S. aureus is becoming an emerging problem too (Popovich et al, 2007;Ribeiro et al, 2007;Stankovic et al, 2007). Antibiotic-resistant strains of S. aureus have been detected in food animals (Lee, 2003) and food like meat (Normanno et al, 2007;Pesavento et al, 2007), milk and dairy products (Gündogân et al, 2006;Peles et al, 2007;Pereira et al, 2009) and also fishery products (Beleneva, 2011), and it may be very hazardous for human health.…”

Molecular Basis and Phenotype of Methicillin Resistance in Staphylococcus aureus and Insights into New β-Lactams That Meet the Challenge

“…Community-associated MRSA (CA-MRSA) strains have a different genetic background, coinciding with increased virulence in animal models, compared with the genetic background of hospital-associated MRSA (HA-MRSA) strains (6,10,42,50,51,134,143,144). Recent cases of infections caused by CA-MRSA in healthy individuals who have no known risk factors for the acquisition of MRSA have raised great concern.…”

The Graying of Methicillin-Resistant Staphylococcus aureus

“…Most populations affected early appeared to share a characteristic of increased risk of disease spread by direct person-to-person contact (Figure). 1 Since the emergence of CA-MRSA strains, several terms have been used to classify S. aureus strains on the basis of epidemiologic, genotypic, and phenotypic characteristics (Table). These classifications provide rough estimates of likely sources of strains and can be used for epidemiologic tracking.…”