Treatment of condyloma acuminata in pregnant women with cryotherapy combined with proanthocyanidins: Outcome and safety

Yang, Lijuan; Zhu, Dongning; Dang, Yanling; Xiong, Zhi‐Gang

doi:10.3892/etm.2016.3207

Cited by 22 publications

(22 citation statements)

References 22 publications

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“…Furthermore, proanthocyanidins were shown to be excellent inhibitors of VEGF and had in vitro and in vivo anti-angiogenic properties that affected angiogenesis by inhibiting of VEGF expression, endothelial cell migration, and vascularization [64,69,70]. In addition, numerous clinical trials of proanthocyanidins have been performed for the treatment of various diseases in patients, and in healthy subjects and pregnant women [10,71,72]. These studies consistently show that proanthocyanidins are effective and safe, warranting their application to a variety of diseases.…”

Section: Characteristics and Clinical Applications Of Proanthocyanidinsmentioning

confidence: 99%

“…As natural active substances without side effects, proanthocyanidins are excellent candidates for the treatment of psoriasis, and their antioxidant, anti-inflammatory, anti-angiogenic, anti-proliferative, and immunomodulatory activities will likely ameliorate OS, Th17/Treg cell imbalances, keratinocyte over-proliferation, and angiogenesis. Finally, proanthocyanidins are safe for infants, pregnant women, and the elderly [72,74].…”

Section: Clinical Significancementioning

confidence: 99%

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Proanthocyanidins: novel treatment for psoriasis that reduces oxidative stress and modulates Th17 and Treg cells

et al. 2018

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Psoriasis is a common, chronic, inflammatory skin disease that affects 2%-4% of the global population. Recent studies have shown that increased oxidative stress (OS) and T-cell abnormalities are central to the pathogenesis of this disease. The resulting reactive oxygen species (ROS) induces proliferation and differentiation of Th17/Th1/Th22 cells and inhibits the anti-inflammatory activities of regulatory T lymphocytes (Treg). Subsequent secretions of inflammatory cytokines, such as interleukin (IL)-17, IL-22, tumor necrosis factor alpha (TNF-α), and interferon-gamma (IFN-γ), and vascular endothelial growth factor (VEGF), stimulate keratinocyte proliferation and angiogenesis. Proanthocyanidins are a class of flavonoids from plants and fruits, and have various antioxidant, anti-inflammatory, and anti-angiogenic properties. Numerous reports have demonstrated therapeutic effects of proanthocyanidins for various diseases. Among clinical activities, proanthocyanidins suppress cell proliferation, prevent OS, and regulate Th17/Treg cells. Because the pathogenesis of psoriasis involves OS and T cells dysregulation, we reviewed the effects of proanthocyanidins on OS, Th17 and Treg cell activities, and keratinocyte proliferation and angiogenesis. Data from multiple previous studies warrant consideration of proanthocyanidins as a promising strategy for the treatment of psoriasis.

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Section: Characteristics and Clinical Applications Of Proanthocyanidinsmentioning

confidence: 99%

Section: Clinical Significancementioning

confidence: 99%

Proanthocyanidins: novel treatment for psoriasis that reduces oxidative stress and modulates Th17 and Treg cells

et al. 2018

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“…Fujii et al further reported that the PCs constituent Oligonol, found in lychee extract, is safe, nontoxic, and nonmutagenic to healthy humans even at 200 mg/day for three months [ 45 ]. Meanwhile, some clinical trials of PCs have been performed for the assessment of safety and the treatment of clinic diseases in healthy subjects and pregnant women, which have demonstrated that daily oral intake of PCs up to 2500 mg is safe in healthy adults and PCs serve as a safe and effective therapy for pregnant women with condyloma acuminata [ 46 , 47 ]. These results indicate that PCs are safe antioxidants with no apparent side effects and so may be widely utilized in clinical medicine and cosmetology.…”

Section: Structure Distribution and Chemical Characteristics Of mentioning

confidence: 99%

Proanthocyanidins against Oxidative Stress: From Molecular Mechanisms to Clinical Applications

Yang

Xian

Xiong

et al. 2018

BioMed Research International

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Proanthocyanidins (PCs) are naturally occurring polyphenolic compounds abundant in many vegetables, plant skins (rind/bark), seeds, flowers, fruits, and nuts. Numerous in vitro and in vivo studies have demonstrated myriad effects potentially beneficial to human health, such as antioxidation, anti-inflammation, immunomodulation, DNA repair, and antitumor activity. Accumulation of prooxidants such as reactive oxygen species (ROS) exceeding cellular antioxidant capacity results in oxidative stress (OS), which can damage macromolecules (DNA, lipids, and proteins), organelles (membranes and mitochondria), and whole tissues. OS is implicated in the pathogenesis and exacerbation of many cardiovascular, neurodegenerative, dermatological, and metabolic diseases, both through direct molecular damage and secondary activation of stress-associated signaling pathways. PCs are promising natural agents to safely prevent acute damage and control chronic diseases at relatively low cost. In this review, we summarize the molecules and signaling pathways involved in OS and the corresponding therapeutic mechanisms of PCs.

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“…Signiicant side efects have been observed for some of these methods, including local ulceration and scar formation, which may reduce a patient's compliance with treatment requirements. Medicine could potentially cause fetal malformation, and laser treatment and surgical excision may cause uterine contraction, or even abortion [32,55]. The safety of imiquimod has not been established, but a small number of patients worldwide have been treated with imiquimod and found to be efective and promising.…”

Section: Treatments In Pregnancymentioning

confidence: 99%

“…The warts are characterized by fast-growing and a reduced tolerance and poor compliance to treatment. Only a few treatments have been tested and recommended in pregnancy [55]. Podoilox (podophyllotoxin), podophyllin and sinecatechins should not be used during pregnancy.…”

Section: Treatments In Pregnancymentioning

confidence: 99%

Anogenital HPV

Aşkın¹

2017

Fundamentals of Sexually Transmitted Infections

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Human papilloma virus (HPV) is the most common sexually transmited infection in the world. HPV is associated with various oral, genital and cutaneous conditions, both benign and malignant. HPV infection can be asymptomatic, but it may persist and cause lesions such as warts, dysplasia and cancers depending on low or high risk type of HPV infection. Anogenital warts are the most common clinical presentation of HPV infection. Despite the high incidence of HPV infections, vaccines, precaution methods and treatments are still maters of debate.

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Treatment of condyloma acuminata in pregnant women with cryotherapy combined with proanthocyanidins: Outcome and safety

Cited by 22 publications

References 22 publications

Proanthocyanidins: novel treatment for psoriasis that reduces oxidative stress and modulates Th17 and Treg cells

Proanthocyanidins: novel treatment for psoriasis that reduces oxidative stress and modulates Th17 and Treg cells

Proanthocyanidins against Oxidative Stress: From Molecular Mechanisms to Clinical Applications

Anogenital HPV

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