Treatment of Congenital Syphilis With Acetarsone (Stovarsol) Given by Mouth

The treatment of syphilis in children has been so varied that we had hoped that a standardized and simplified method could be used in all cases of congenital syphilis. Arsenicals in the form of neoarsphenamine and sulpharsphenamine, mercurials in different forms and bismuth preparations have been the outstanding medications in all clinics. These drugs are given intravenously or intramuscularly. The use of oral medication has been discarded for many years. However, as there are many discomforts attending the use of hypodermic injection, there is no reason why an attempt should not be made to return to oral administration if it produces results similar to those received from intramuscular or intravenous injections.The drug employed in our cases was a preparation used by Levaditi and Ehrlich. It is known under the names acetarsone, stovarsol and spirocid. Levaditi and Navarro-Martin 1 were first able to demonstrate its effectiveness when used by mouth in the prevention and treatment of syphilis in man and animals. REVIEW OF THE LITERATUREAbt2 recently reported a study of twenty-two cases. He summarized his results as follows :Cutaneous lesions cleared in one to three weeks. The improvement in the gen¬ eral condition of the children was impressive. The appetite increased and the gain in weight was marked, average gain being 4 pounds 4 ounces for the nine weeks' course of treatment. The Wassermann reaction in our series of cases after treat¬ ment with one course of acetarsone became negative in 59 per cent of the cases. Most of the negative Wassermann reactions were obtained in infants under one year. The Kahn test became negative in 30 per cent of the cases. No serious The brand of acetarsone used was stovarsol.

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Treatment of Congenital Syphilis With Acetarsone (Stovarsol) Given by Mouth

Cited by 16 publications

References 18 publications

Acetarsone in the Treatment of Neurosyphilis

Acetarsone in the Treatment of Neurosyphilis

Treatment of Congenital Syphilis With Acetarsone (Stovarsol) by Mouth

Acetarsone in the Treatment of Syphilis in Negro Children

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