Treatment of conjunctival melanoma in a Dutch referral centre

Brouwer, Niels J.; Marinković, Marina; Duinen, Sjoerd G. van; Bleeker, J.C.; Jager, Martine J.; Luyten, Gregorius P M

doi:10.1136/bjophthalmol-2017-311082

Cited by 42 publications

(41 citation statements)

References 19 publications

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“…Also, we were able to investigate eye colour, tumour pigmentation and skin colour together, which is interesting as these parameters all depend on similar pathways of melanin production. Recently, a study was published on clinical parameters that were associated with outcome in CoM in the Leiden group, identifying the hospital of initial treatment and the type of treatment as prognostically important for the development of recurrences 16. Prior to this, an analysis of patients that included the WEH group identified other parameters such as tumour origin and location as being related to metastasis development 17.…”

Section: Discussionmentioning

confidence: 99%

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Lack of tumour pigmentation in conjunctival melanoma is associated with light iris colour and worse prognosis

et al. 2018

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Lightly pigmented tumours occurred especially in individuals with lightly coloured irises. While iris colour or skin colour was not significantly related to clinical outcome, a low tumour pigmentation was related to a worse outcome in patients with conjunctival melanoma. The amount and type of melanin in conjunctival melanocytes may be involved in the pathogenesis and behaviour of selected conjunctival melanoma.

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Section: Discussionmentioning

confidence: 99%

“…The Leiden group consisted of 70 patients with histopathologically confirmed primary CoM, diagnosed between 2001 and 2014 16. The WEH group consisted of 374 patients with histopathologically confirmed primary CoM, diagnosed between 1970 and 2003.…”

Section: Methodsmentioning

confidence: 99%

Lack of tumour pigmentation in conjunctival melanoma is associated with light iris colour and worse prognosis

et al. 2018

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“…Although the patient was treated with capecitabine chemotherapy for her colon carcinoma, this will be of limited relevance as capecitabine (or another form of 5-FU) is not indicated for the treatment of CoM [15, 16]. Regarding the first episode of CoM with accompanying histologic PAM in our patient, we would currently advise to apply mitomycin C drops after excision to reduce the recurrence risk [17]. …”

Section: Discussionmentioning

confidence: 99%

Two Late Recurrences of Conjunctival Melanoma

et al. 2018

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Purpose: To report a patient who developed two late recurrences of conjunctival melanoma (CoM), of which one occurred after orbital exenteration. Methods: We describe the case of a patient based on clinical and histopathological examination. Results: A 52-year-old patient was treated with local excision and cryotherapy for a CoM with primary acquired melanosis (PAM) near the limbus of the right eye. Twenty-one years later, a recurrence developed in the superior fornix of the same eye in an area with widespread PAM; an orbital exenteration was performed. After another 4 years, a painful nodule developed subcutaneously at the inferior margin of the right orbital socket. Pathology showed a recurrence of CoM with a BRAF V600K mutation, similar to both of the previous lesions (of 25 and 4 years earlier). The nodule was excised without additional therapy. No recurrences or metastases have been observed in the next 2.5 years. The proposed mechanism for the recurrence after surgery could be via dormant tumor cells that have spread prior to the procedure or via residual intraepithelial malignant melanocytes. Conclusion: Very late recurrences of CoM are rare but may occur. Our case illustrates the need for long-term awareness of doctors and patients, even after extensive surgical procedures such as orbital exenteration.

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“…Brouwer 18 CM-es beteget kezelt sebészi excisióval és 7 pácienst sebészi eltávolítással és cryotherapiával. 70,2 hónapos utánkövetésnél lokális recidíva kizárólagos sebészi eltávolítást követően a betegek 50%-ánál, a sebészi eltávolítás cryotherapiával történő kombinálása esetén 14%-uknál jelentkezett [38].…”

Section: Intraoperatív Adjuváns Kezelések Cryotherapiaunclassified

Pigmentsejt-eredetű szemfelszíni elváltozások differenciáldiagnózisa és kezelése

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et al. 2020

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Absztrakt: Célunk a pigmentsejt-eredetű szemfelszíni elváltozások (conjunctivalis naevus, primer szerzett melanosis és conjunctivalis melanoma) összefoglaló ismertetése, különös hangsúlyt fektetve a klinikai megjelenésre, differenciáldiagnosztikára és kezelésre. A naevus a leggyakoribb benignus, pigmentsejt-eredetű conjunctivatumor. A primer szerzett (akvirált) melanosis közép- vagy időskorúakban jelenik meg, a conjunctivalis hám melanocytáinak proliferációja következtében. A conjunctivalis melanoma ritka daganat, a szemfelszíni laphám-neoplasia után a második leggyakoribb szemfelszíni malignus tumor, illetve a chorioidealis melanoma malignumot és a szemfelszíni laphám-neoplasiát követően a harmadik leggyakoribb ocularis malignoma. Rendkívül magas malignitási és áttétképzési potenciálja miatt fontos a korai felismerése és a megfelelő módon való kezelése. A gyakori recidívaképződés miatt kezelésében elengedhetetlen az intra- és posztoperatív adjuváns kezelési módok ismerete és alkalmazása, valamint a rendszeres kontrollvizsgálat. Orv Hetil. 2020; 161(15): 563–574.

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Treatment of conjunctival melanoma in a Dutch referral centre

Cited by 42 publications

References 19 publications

Lack of tumour pigmentation in conjunctival melanoma is associated with light iris colour and worse prognosis

Lack of tumour pigmentation in conjunctival melanoma is associated with light iris colour and worse prognosis

Two Late Recurrences of Conjunctival Melanoma

Pigmentsejt-eredetű szemfelszíni elváltozások differenciáldiagnózisa és kezelése

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