Treatment of constipation-predominant irritable bowel syndrome by focusing on the liver in terms of Traditional Chinese Medicine: a meta-analysis

Li, Qian-wen; Liu, Fengbin; Hou, Zheng-kun; Luo, Dan

doi:10.1016/s0254-6272(14)60022-4

Cited by 13 publications

(20 citation statements)

References 4 publications

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“…TCM: Eine MA 646 (19 RCTs, N = 1510) zum RDS-Subtyp Obstipation verglich TCM mit Fokus auf der Leber mit westlicher Schulmedizin hinsichtlich eines globalen Wirksamkeitsmaßes und kommt zu dem Ergebnis, dass TCM wirksamer ist. Die Studienqualität der inkludierten RCTs ist allerdings sehr gering und ein Publikationsbias wurde bestätigt, weswegen diese Ergebnisse kaum zu verwenden sind.…”

Section: Teil IV – Allgemeine Therapieverfahrenunclassified

See 1 more Smart Citation

Update S3-Leitlinie Reizdarmsyndrom: Definition, Pathophysiologie, Diagnostik und Therapie. Gemeinsame Leitlinie der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) und der Deutschen Gesellschaft für Neurogastroenterologie und Motilität (DGNM) – Juni 2021 – AWMF-Registriernummer: 021/016

et al. 2021

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Section: Teil IV – Allgemeine Therapieverfahrenunclassified

“…Schmerzen Blähungen Obstipation Diarrhoe Globaler RDS-Symptomkomplex 1. Ganzheitliche Medizinsysteme TCM [645][646][647] Akupunktur [641][642][643][644] x…”

Section: Interventionunclassified

Update S3-Leitlinie Reizdarmsyndrom: Definition, Pathophysiologie, Diagnostik und Therapie. Gemeinsame Leitlinie der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) und der Deutschen Gesellschaft für Neurogastroenterologie und Motilität (DGNM) – Juni 2021 – AWMF-Registriernummer: 021/016

et al. 2021

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“…We identified 212 studies in the six databases. After removing duplications and excluding studies that did not meet the inclusion criteria by reading the titles, abstracts, and full texts, 17 SRs ( Spanier et al, 2003 ; Bian et al, 2006 ; Liu et al, 2006 ; Shi et al, 2008 ; Li et al, 2013 , 2015 , 2017 ; Zhang et al, 2014 ; Xiao Y. et al, 2015 ; Zhu et al, 2016 ; Dai et al, 2018 ; Zhou et al, 2019 ; Bu et al, 2020 ; Wang et al, 2020 ; Tan et al, 2020 ; Yao et al, 2021 ; Zheng et al, 2021 ) were found to be eligible for this overview. Among these SRs, 16 SRs and an overview of SRs ( Zhang et al, 2014 ) were included.…”

Section: Resultsmentioning

confidence: 99%

An Overview of Systematic Reviews of Herbal Medicine for Irritable Bowel Syndrome

Jun

Kim

et al. 2022

Front. Pharmacol.

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Background: Irritable bowel syndrome (IBS) is a common disorder with abdominal pain and bowel habits changes. Herbal medicines (HMs) are frequently used in the treatment of IBS. Therefore, several systematic reviews (SRs) have been conducted to assess the efficacy and safety of HM in IBS patients. This study aimed to investigate the methodology and quality of evidence of SRs, and to describe the current state of research and evidence for the treatment of IBS with HM.Methods: SRs published up to January 2022 were searched using six electronic databases. SRs and/or meta-analyses on the use of HMs for IBS were included. The effects of placebo, conventional medicine (CM), and probiotics were compared with those of HMs. Two investigators independently extracted the data and assessed methodological quality using the Measure Tool to Assessment System Reviews 2 (AMSTAR 2). Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) was used to evaluate the quality of evidence for each main finding.Results: Eighteen SRs were included in this overview. Among them, eight SRs reported only specific subtypes of IBS: six SRs reported patients with diarrhea-predominant IBS, and two SRs reported patients with constipation-predominant IBS. In terms of total efficacy, HM was more effective than placebo, CM, or probiotics. HM showed a more significant effect than CM in relieving independent IBS symptom score (abdominal pain score, diarrhea score, abdominal distension score, stool frequency score, etc.) and recurrence rate. The rate of adverse events was significantly lower with HM compared to CM, and no serious adverse events were reported with HM treatment. According to AMSTAR 2, the methodological quality of the included SRs was extremely low. Furthermore, the quality of evidence for total efficacy was considered low or very low according to the GRADE tool.Conclusion: HM can be considered as an effective and safe treatment for IBS. However, the methodological quality of the included SRs and the quality of evidence was generally low. Therefore, well-designed randomized controlled trials are needed in the future so that a high-quality SR can be used to better assess the safety and efficacy of HM in the treatment of IBS.Systematic Review Registration:https://osf.io/nt6wz, identifier 10.17605/OSF.IO/NT6WZ.

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“…Of the 18 studies (22.2%) [ 33 , 35 , 37 , 41 , 42 , 49 , 62 , 65 , 79 , 81 , 83 , 86 – 88 , 91 , 99 , 102 , 107 ] reporting outcomes on adverse events, seven studies [ 37 , 49 , 65 , 79 , 83 , 88 , 91 ] found no adverse events, and four studies [ 35 , 62 , 81 , 87 ] reported patients having slight bleeding when the needle was withdrawn. The remaining seven studies reported adverse events from eye acupuncture as well as events from other interventions during the treatment, which are shown in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

Eye acupuncture for pain conditions: a scoping review of clinical studies

Yuan

Barth

Wang

et al. 2021

BMC Complement Med Ther

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Background Chinese eye acupuncture, focuses on treating different diseases by applying needle stimulation around the orbit of the eye. Since 1970, it has been used in China for the management of pain-related disorders. This scoping review systematically collected clinical studies on the use of eye acupuncture to treat pain conditions and identify any adverse events. Methods Six databases including PubMed, the Cochrane Library, CNKI, VIP, Wan Fang Data and SinoMed were searched from 1970 to March 2019. Randomized controlled trials (RCTs), clinical controlled trials (CCTs) and case series on eye-acupuncture for pain conditions meeting the inclusion criteria were identified. Data were extracted on patients, interventions, details of eye acupuncture, control treatments and outcomes. Results Searches identified 81 clinical studies and a trend demonstrating an increasing number of published studies. All studies were conducted in China and published in Chinese. These included, 45 (55.6%) RCTs, 5 (6.2%) CCTs, and 31 (38.3%) case series, treating 7113 patients with 44 different pain-related diseases or symptoms. The most frequently reported conditions were headache (18, 16.2%), acute lumbar pain (7, 6.3%) and lumbar disc herniation (7, 6.3%). Treatment using small needles (φ0.25 × 13 mm), retained ≤30 min, needling the horizontal outer orbital edge and the avoidance of manipulation during treatment were the most frequent descriptions of the interventions used. Eye acupuncture was used alone in about half of the studies and of the remaining studies it was combined with other treatment. All studies suggested some beneficial effects including: pain relief, improved quality of life and mental health, and 18 (22.2%) adverse events. Conclusion Eye acupuncture, predominantly studied in China, may be a promising intervention for managing diverse pain conditions. However, given the variety of study designs and reported treatment outcomes, conclusions about the evidence for eye acupuncture for specific conditions are not possible at this stage.

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Treatment of constipation-predominant irritable bowel syndrome by focusing on the liver in terms of Traditional Chinese Medicine: a meta-analysis

Abstract: Compared with Western Medicine, the treatment of IBS-C based on the liver is significantly better but the results must be treated with caution because publication bias was recorded.

Cited by 13 publications

References 4 publications

An Overview of Systematic Reviews of Herbal Medicine for Irritable Bowel Syndrome

Eye acupuncture for pain conditions: a scoping review of clinical studies

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