Treatment of COVID-19 disease in pregnancy and breastfeeding

Abstract

The physiological and anatomical clinical characteristics of pregnant women make them susceptible to complications caused by coronavirus disease (COVID-19). Increased coagulation and risk of thromboembolic phenomena are common during pregnancy; they are further enhanced when associated with a thrombogenic pathology such as in COVID-19. The treatment of COVID-19 is controversial and limited, even for non-pregnant patients. During pregnancy, the options are even more restricted due to the teratogenicity of some drugs and anatomical and physiological difficulties, especially in advanced pregnancy in patients with respiratory failure. Therefore, the focus of treatment for pregnant patients should be centered on isolation, monitoring fetal and maternal vital signs, uterine activity, and general maternal-fetal well-being. The prescription of drugs and management orientation should be based on gestational age and maternal clinical conditions. The optimal type of delivery is guided by obstetric indications and COVID-19 disease severity. Breastfeeding should be encouraged with the use of masks and hand hygiene. The treatment of pregnant women with COVID-19 brings important peculiarities that should be considered in order to make better decisions for preserving the health of the mother and fetus.

The Effect Of Corticosteroids On Adverse Infant Outcomes In Pregnant Women With SARS-Cov-2 Infection; Still A Neglected Era: A Systematic Review.

“…One of the main therapeutic challenges is the use of corticosteroids in pregnancy and COVID-19 [4]. There are controversial results regarding the indication to begin, the best type and the optimal dose of corticosteroids for managing COVID-19 [5].…”

“…In a review study of COVID-19 therapeutics in pregnancy (2022) report that there are many important knowledge gaps about the safety and efficacy of key therapeutics used for COVID-19 in pregnancy [4].In another study(2021) show that increased coagulation and risk of thromboembolic phenomena are common during pregnancy; they are further enhanced when associated with a thrombogenic pathology such as in COVID-19. The treatment of pregnant women with COVID-19 brings important peculiarities that should be considered in order to make better decisions for preserving the health of the mother and fetus[5]. According to the literature, So far, there are no published articles on corticosteroid use among pregnant women with covid-19 disease.…”