Treatment of Diabetic Neuropathy

Pop‐Busui, Rodica; Simmons, Zachary; Feldman, Eva L.

doi:10.1002/9780470682807.ch19

Cited by 1 publication

(1 citation statement)

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“…Patients have reported the spreadinglike stocking-glove pattern. Once it reaches knee level, the pain, tingling, and numbness moves to the fingers [18]. Patients presenting with more symptoms or signs of nerve dysfunction can be a strong indicator of the diagnosis.…”

Section: Patient Presentationmentioning

confidence: 99%

Diabetic Neuropathic Pain: Pathophysiology & Treatment

Geeso,

Galan

2023

Preprint

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Diabetes mellitus is the global epidemic of the 21st century affecting millions worldwide. Usually, patients with long-standing type one diabetes (T1D) or type two diabetes (T2D) tend to develop complications. A common complication is the degenerative of the nerves in the peripheral nervous system (PNS). This complication is known as distal symmetric polyneuropathy or just diabetic neuropathy. A variety of symptoms can be experienced with this complication, including pain and numbness. One characterization of this complication is the sensory loss that begins in the lower extremities and spreads substantially to the fingers and hand. There is no clear mechanism for how this happens in diabetic patients. Studies have shown that nerve damage from this complication can be due to oxidative stress, sorbitol accumulation, and advanced glycation end products (AGEs). Some of the most common medications being provided for diabetic neuropathic pain (DNP) include amitriptyline and desipramine. Other medications also include gabapentin and duloxetine. There are noninvasive options, such as acupuncture, that could provide beneficial data if rigorous studies are conducted. A number of new studies are being completed to identify more effective treatments for this condition.

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Section: Patient Presentationmentioning

confidence: 99%