Treatment of Diffuse Basal Cell Carcinomas and Basaloid Follicular Hamartomas in Nevoid Basal Cell Carcinoma Syndrome by Wide-Area 5-Aminolevulinic Acid Photodynamic Therapy

Oseroff, Allan R.; Shieh, Sherry; Frawley, Noreen P.; Cheney, Richard; Blumenson, Leslie E.; Pivnick, Enikö K.; Bellnier, David A.

doi:10.1001/archderm.141.1.60

Cited by 91 publications

(89 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As it turned out, there was no difference between any of the parameters evaluated for treatment response between the two sources. Consistent with previous reports pointing to the importance of PDT dose in modulating the treatment outcome, 6,36,[40][41][42] we observed regions of viable tumor [ Fig. 4(a)] even at a high incident dose of 100 J∕cm 2 possibly due to heterogeneous PpIX accumulation or light distribution.…”

Section: Resultssupporting

confidence: 92%

In vivoevaluation of battery-operated light-emitting diode-based photodynamic therapy efficacy using tumor volume and biomarker expression as endpoints

et al. 2015

View full text Add to dashboard Cite

Abstract. In view of the increase in cancer-related mortality rates in low-to middle-income countries (LMIC), there is an urgent need to develop economical therapies that can be utilized at minimal infrastructure institutions. Photodynamic therapy (PDT), a photochemistry-based treatment modality, offers such a possibility provided that low-cost light sources and photosensitizers are available. In this proof-of-principle study, we focus on adapting the PDT light source to a low-resource setting and compare an inexpensive, portable, battery-powered lightemitting diode (LED) light source with a standard, high-cost laser source. The comparison studies were performed in vivo in a xenograft murine model of human squamous cell carcinoma subjected to 5-aminolevulinic acid-induced protoporphyrin IX PDT. We observed virtually identical control of the tumor burden by both the LED source and the standard laser source. Further insights into the biological response were evaluated by biomarker analysis of necrosis, microvessel density, and hypoxia [carbonic anhydrase IX (CAIX) expression] among groups of control, LED-PDT, and laser-PDT treated mice. There is no significant difference in the percent necrotic volume and CAIX expression in tumors that were treated with the two different light sources. These encouraging preliminary results merit further investigations in orthotopic animal models of cancers prevalent in LMICs.

show abstract

Section: Resultssupporting

confidence: 92%

In vivoevaluation of battery-operated light-emitting diode-based photodynamic therapy efficacy using tumor volume and biomarker expression as endpoints

et al. 2015

View full text Add to dashboard Cite

show abstract

“…To our knowledge, only 3 studies [5,6,7] among the 13 previously reported cases of PDT of NBCCS patients give response rates of the procedure [5,6,7,8,9,10,11,12]. Indeed, most of them are single case reports, the largest studies include 3 patients [6, 7].…”

Section: Commentmentioning

confidence: 99%

“…Oseroff et al [6] report 82, 85 and 93% of median initial response rate for each of their 3 young patients. No distinction was made between sBCC, nBCC and pigmented BCC.…”

Section: Commentmentioning

confidence: 99%

Methylaminolaevulinate Photodynamic Therapy in Patients with Multiple Basal Cell Carcinomas in the Setting of Gorlin-Goltz Syndrome or after Radiotherapy

Mougel

Debarbieux²,

Ronger-Savlé³

et al. 2009

Dermatology

View full text Add to dashboard Cite

Background: The naevoid basal cell carcinoma syndrome (NBCCS) is a therapeutic challenge due to the multiplicity of cutaneous tumours. Photodynamic therapy (PDT) is increasingly used as an alternative treatment for superficial and in some countries nodular basal cell carcinomas (BCC). Objective: To study the safety and efficiency of PDT in NBCCS. Methods: We reviewed retrospectively the evolution of 62 lesions from patients with multiple BCC treated with PDT. Results: The initial response rate (85.4%, 53/62) and recurrence rate (7.5%) appeared comparable to literature values in NBCCS and to those reported in the treatment of sporadic BCC. The clearance rate without recurrence was 79% (49/62), during a mean follow-up period of 13 months. The cosmetic outcome was excellent. Recurrences were found almost 2 years after treatment. Conclusion: PDT is a suitable therapeutic option in the management of NBCCS patients but requires a strict and long follow-up.

show abstract

“…To reduce the pain, general anesthesia may be used, most often when treating children or extensive lesions, or local anesthesia and also premedication with opioids. However, the latter proved inefficient (Itkin &Gilchrest, 2004;Oseroff, 2005). The results of PDT are estimated by the disappearance of the tumor, this occurs normally after 2-3 days.…”

Section: Clinical Resultsmentioning

confidence: 99%

Photodynamic Therapy in Skin Cancer

Clichici¹,

Filip²

2011

Skin Cancers - Risk Factors, Prevention and Therapy

View full text Add to dashboard Cite

Treatment of Diffuse Basal Cell Carcinomas and Basaloid Follicular Hamartomas in Nevoid Basal Cell Carcinoma Syndrome by Wide-Area 5-Aminolevulinic Acid Photodynamic Therapy

Cited by 91 publications

References 44 publications

In vivoevaluation of battery-operated light-emitting diode-based photodynamic therapy efficacy using tumor volume and biomarker expression as endpoints

In vivoevaluation of battery-operated light-emitting diode-based photodynamic therapy efficacy using tumor volume and biomarker expression as endpoints

Methylaminolaevulinate Photodynamic Therapy in Patients with Multiple Basal Cell Carcinomas in the Setting of Gorlin-Goltz Syndrome or after Radiotherapy

Photodynamic Therapy in Skin Cancer

Contact Info

Product

Resources

About