Treatment of dissecting cellulitis of the scalp with 10% ALA‐PDT

Feng, Yu-Xin; Zhang, Yuhui; Guo, Hongzuo; Lin, Zheng; Chen, Hongqiang; Wu, Yan; Gao, Xinghua; Chen, Hong‐Duo

doi:10.1002/lsm.23016

Cited by 26 publications

(12 citation statements)

References 26 publications

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“…Dissecting cellulitis of the scalp is a rare chronic and recalcitrant scarring neutrophilic alopecia. 17 Therapy for this condition includes isotretinoin, antibiotics, steroids, anti-Tumor necrosis factor agents and even surgery, among others. Nonetheless, results are frequently disappointing.…”

Section: Dissecting Cellulitis Of the Scalpmentioning

confidence: 99%

“…Therefore, PDT has been tried in this condition with favorable results. In fact, PDT seems to be effective and safe in the treatment of dissecting cellulitis of the scalp, with a sustained effect even after the end of the treatment 17 . Although protocols remain to be defined, this less invasive treatment may be an alternative for patients with this devastating condition.…”

Section: Potential Indications For Pdtmentioning

confidence: 99%

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Photodynamic therapy in dermatology: Beyond current indications

Queirós

Garrido

Silva

et al. 2020

Dermatologic Therapy

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Photodynamic therapy (PDT) has long been used in dermatology as a therapeutic strategy for several malignant and premalignant conditions. Currently, it is approved in Europe for the treatment of actinic keratosis, squamous cell carcinoma in situ, and some forms of basal cell carcinoma, with favorable clearance rates associated with satisfying aesthetic results. Nonetheless, in the past few years, PDT has also demonstrated efficacy in many other conditions, including inflammatory and infectious dermatoses. These results, probably explained by its immunomodulatory, anti-inflammatory, and bactericidal effects, may lead to an expansion of PDT indications in the upcoming years. In this article, conditions where PDT may be useful are reviewed, thus highlighting the potential of this therapeutic modality for the dermatologist.

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Section: Dissecting Cellulitis Of the Scalpmentioning

confidence: 99%

Section: Potential Indications For Pdtmentioning

confidence: 99%

Photodynamic therapy in dermatology: Beyond current indications

Queirós

Garrido

Silva

et al. 2020

Dermatologic Therapy

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“…There have been three recent case studies detailing the use of multiple sessions of 10% aminolevulinic acid during photodynamic therapy (ALA-PDT) laser treatment as an alternative to isotretinoin [28][29][30]. These studies have cited significant improvement or complete remission in patients with DCS at an efficacy comparable to isotretinoin [28][29][30]. No recurrence was cited in two studies (follow-up at 7 weeks [30] and 3 months [28]).…”

Section: Treatment Alternativesmentioning

confidence: 99%

“…These studies have cited significant improvement or complete remission in patients with DCS at an efficacy comparable to isotretinoin [28][29][30]. No recurrence was cited in two studies (follow-up at 7 weeks [30] and 3 months [28]). Treatment with 10% ALA-PDT may also be a safe alternative for dissecting cellulitis that is refractory to isotretinoin, patients who have adverse effects from using isotretinoin (acne fulminans [31], pseudotumor cerebri [32], hepatotoxicity [33]), alcoholics [33], or pregnant women [34].…”

Section: Treatment Alternativesmentioning

confidence: 99%

“…Treatment with 10% ALA-PDT may also be a safe alternative for dissecting cellulitis that is refractory to isotretinoin, patients who have adverse effects from using isotretinoin (acne fulminans [31], pseudotumor cerebri [32], hepatotoxicity [33]), alcoholics [33], or pregnant women [34]. It is also an attractive option in that it may offer a lower rate of recurrence than isotretinoin [28,30]. However, more data are needed.…”

Section: Treatment Alternativesmentioning

confidence: 99%

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Analyzing the Efficacy of Isotretinoin in Treating Dissecting Cellulitis: A Literature Review and Meta-Analysis

et al. 2021

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Background and Objective Dissecting cellulitis of the scalp is a primary scarring alopecia. Isotretinoin is commonly referenced in the literature as a treatment for dissecting cellulitis. The objective of this article was to conduct a review and meta-analysis to assess the efficacy of isotretinoin for treating dissecting cellulitis of the scalp. Methods The following databases were searched for articles prior to 23 June, 2019: PubMed, Embase, Cochrane Central, CINAHL, and Web of Science. Multi-patient studies (more than three) that reported on the administration of isotretinoin for dissecting cellulitis were included. A pooled meta-analysis for improvement of disease burden after isotretinoin administration in patients with dissecting cellulitis of the scalp was performed. A fixed-effects model was used. Results Five articles were ultimately used for the quantitative meta-analysis. The overall efficacy rate of isotretinoin in treating dissecting cellulitis of the scalp was estimated to be 0.9 with a 95% confidence interval (0.81–0.97). The sensitivity analysis suggested that the overall efficacy is still very high, with a range of 0.83–0.94. Recurrence was seen in 24% (6/25) of patients. Common associated diseases amongst patients with dissecting cellulitis of the scalp were acne conglobata 20% (30/151) and hidradenitis suppurativa 19% (11/72). Conclusions Isotretinoin is an effective treatment for improving symptoms of dissecting cellulitis of the scalp. Disease recurrence is a common finding for those who undergo successful treatment.

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Acquired Disorders of Hair

Harries,

Holmes,

McMichael

et al. 2024

Rook's Textbook of Dermatology

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This chapter reviews acquired hair disorders, including common scarring and non‐scarring alopecia presentations, conditions characterised by excessive body hair growth and acquired hair shaft disorders. We also describe the biology of normal hair follicles, including structure, hair cycle control and immunity, to better understand the mechanisms underlying these conditions. We present methods for clinical assessment, recommended investigation and management of each disease, and present summaries of frequently used therapeutics and cosmetic options employed when treating these problems.

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Treatment of dissecting cellulitis of the scalp with 10% ALA‐PDT

Abstract: 10% ALA-PDT is effective and safe on male DCS patients. As a localized and less invasive treatment, it provides a preferable choice for DCS patients. Lasers Surg. Med. © 2018 Wiley Periodicals, Inc.

Cited by 26 publications

References 26 publications

Photodynamic therapy in dermatology: Beyond current indications

Photodynamic therapy in dermatology: Beyond current indications

Analyzing the Efficacy of Isotretinoin in Treating Dissecting Cellulitis: A Literature Review and Meta-Analysis

Acquired Disorders of Hair

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