2015
DOI: 10.1093/cid/civ416
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Treatment of Disseminated Leishmaniasis With Liposomal Amphotericin B

Abstract: NCT02025491.

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Cited by 53 publications
(33 citation statements)
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“…DL is an emerging and severe form of L. (V.) braziliensis infection associated with a high rate of ML and failure to antimony therapy. 4,7 Substantial variability among the leishmania at the subgenus level has been described, and there are evidences that genotypic differences intraspecies may influence the presentation of the disease 10 and response to therapy. 13 However, the biological behaviour of The role played by neutrophils in the pathogenesis of leishmania infection has been only recently emphasized.…”
Section: Discussionmentioning
confidence: 99%
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“…DL is an emerging and severe form of L. (V.) braziliensis infection associated with a high rate of ML and failure to antimony therapy. 4,7 Substantial variability among the leishmania at the subgenus level has been described, and there are evidences that genotypic differences intraspecies may influence the presentation of the disease 10 and response to therapy. 13 However, the biological behaviour of The role played by neutrophils in the pathogenesis of leishmania infection has been only recently emphasized.…”
Section: Discussionmentioning
confidence: 99%
“…There are several indicators of the relevance to study this atypical presentation of ATL. DL is an emergent form of leishmaniasis as its prevalence increased 20‐fold from 1986 to 2012, up to 40% of DL patients have ML and the disease is associated with a high hate of failure to antimony therapy . The pathogenesis of DL is not fully understood.…”
Section: Introductionmentioning
confidence: 99%
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“…With chronic infections, the lesions have abundant parasites and persist for 20 years or more. Disseminated cutaneous leishmaniasis is characterized by multiple ulcerative or acneiform skin lesions and by a strongly positive leishmanin skin test (13)(14)(15). Mucocutaneous leishmaniasis is more common in the New World, with almost no cases found in the Old World.…”
Section: Clinical Manifestationsmentioning
confidence: 99%
“…Because of its powerful activity, AmB is still the most frequently used antifungal in hospitals despite the development of a number of new antifungal agents (Machado et al, 2015). However, AmB is not recommended as the first choice for the treatment of patients with progressive, potentially lifethreatening fungal infections.…”
Section: Introductionmentioning
confidence: 99%