Treatment of Early Lyme Disease

Stricker, Raphael B.; Gaito, Andrea; Harris, N.; Burrascano, Joseph J.

doi:10.7326/0003-4819-140-7-200404060-00022

Cited by 5 publications

(3 citation statements)

References 8 publications

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“…; Stricker et al . ; Larkin ; Hansmann ; Shapiro ), and for late stages of the disease ceftriaxone or cefotaxime (Maraspin et al . ; Delong et al .…”

Section: Introductionmentioning

confidence: 99%

In vitro evaluation of antibacterial activity of phytochemicals and micronutrients against Borrelia burgdorferi and Borrelia garinii

2015

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AimsLittle is known about the effects of phytochemicals against Borrelia sp. causing Lyme disease. Current therapeutic approach to this disease is limited to antibiotics. This study examined the anti‐borreliae efficacy of several plant‐derived compounds and micronutrients.Methods and ResultsWe tested the efficacy of 15 phytochemicals and micronutrients against three morphological forms of Borrelia burgdoferi and Borrelia garinii: spirochetes, latent rounded forms and biofilm. The results showed that the most potent substances against the spirochete and rounded forms of B. burgdorferi and B. garinii were cis‐2‐decenoic acid, baicalein, monolaurin and kelp (iodine); whereas, only baicalein and monolaurin revealed significant activity against the biofilm. Moreover, cis‐2‐decenoic acid, baicalein and monolaurin did not cause statistically significant cytotoxicity to human HepG2 cells up to 125 μg ml−1 and kelp up to 20 μg ml−1.ConclusionsThe most effective antimicrobial compounds against all morphological forms of the two tested Borrelia sp. were baicalein and monolaurin. This might indicate that the presence of fatty acid and phenyl groups is important for comprehensive antibacterial activity.Significance and Impact of the StudyThis study reveals the potential of phytochemicals as an important tool in the fight against the species of Borrelia causing Lyme disease.

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“…; Stricker et al . ; Larkin ; Hansmann ; Shapiro ), and for late stages of the disease ceftriaxone or cefotaxime (Maraspin et al . ; Delong et al .…”

Section: Introductionmentioning

confidence: 99%

In vitro evaluation of antibacterial activity of phytochemicals and micronutrients against Borrelia burgdorferi and Borrelia garinii

2015

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“…The hepatic toxicity of evernimicin makes it doubtful that this risky antibiotic will ever be marketed for Lyme disease. Shorter course antibiotic therapy was the subject of a recent study [65] , and this minimalist approach promises to yield more inadequately treated Lyme disease sufferers [66] .…”

Section: Introductionmentioning

confidence: 99%

“…The use of single-dose doxycycline also raises concern about antibiotic resistance following this microbiologically unsound therapy. A more recent study of ultrashort course doxycycline therapy (10 days) for early Lyme disease had signifi cant design fl aws and showed effi cacy in less than 50% of patients [65,66] .…”

Section: Introductionmentioning

confidence: 99%

Lyme Disease: The Quest for Magic Bullets

Stricker

Lautin²,

Burrascano³

2006

Chemotherapy

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Lyme disease represents a growing public health threat. Recent molecular and genetic studies have confirmed that Borrelia burgdorferi, the spirochetal agent of Lyme disease, is one of the most complex bacteria known to man. Affinity for multiple cell types and the presence of non-replicating forms of B. burgdorferi have contributed to persistent infection and failure of simple antibiotic regimens. The controversial clinical science of Lyme disease has impeded reliable diagnosis and effective treatment of this protean illness. Two major clinical hurdles are the absence of a therapeutic endpoint in treatingLyme disease and the presence of tick-borne coinfections that may complicate the course of the illness. New strategies for the diagnosis, treatment and prevention of Lyme disease are urgently needed.

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Evaluation of Tests for Lyme Disease

Spinhirne

2006

J Clin Microbiol

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Treatment of Early Lyme Disease

Cited by 5 publications

References 8 publications

In vitro evaluation of antibacterial activity of phytochemicals and micronutrients against Borrelia burgdorferi and Borrelia garinii

In vitro evaluation of antibacterial activity of phytochemicals and micronutrients against Borrelia burgdorferi and Borrelia garinii

Lyme Disease: The Quest for Magic Bullets

Evaluation of Tests for Lyme Disease

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