Treatment of early-onset schizophrenia

Mattai, Anand; Hill, Julia L.; Lenroot, Rhoshel

doi:10.1097/yco.0b013e32833b027e

Cited by 40 publications

(20 citation statements)

References 60 publications

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“…Notably, these patients were adolescents with early-onset schizophrenia. Most were diagnosed by age ≤13 years, constituting a sample with early age of onset even in comparison to other adolescent schizophrenia studies (Mattai et al, 2010). This analysis demonstrated a significant, albeit modest, correlation of paternal age with treatment response in adolescents with schizophrenia, but not with the age of onset or initial symptom severity in the offspring.…”

Section: Discussionmentioning

confidence: 93%

Effect of parental age on treatment response in adolescents with schizophrenia

Opler

Malaspina

Gopal

et al. 2013

Schizophrenia Research

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Background Advanced paternal age (APA) is associated with increased risk for schizophrenia, but its effect on treatment response has not been longitudinally studied. Methods Association of parental ages at the time of the child's birth with age of onset, initial symptom severity and treatment response (to placebo and three different weight-based doses of paliperidone ER) in adolescents with schizophrenia was assessed in a post-hoc analysis using data from a 6-week double-blind study, the primary results of which are published (NCT 00518323). Results The mean (SD) paternal age was 29.2 (6.2) years, range (16-50) and maternal age was 26.8 (5.7) years, range (17-42) at childbirth for the 201 adolescents (ages 12-17 years) included in the analysis. While parental ages were uncorrelated with age of onset or initial symptom severity, both maternal and paternal age showed significant effects on treatment response (p < 0.03) of all paliperidone ER arms versus placebo. Paternal age was significantly correlated to improvement in positive symptoms and maternal age significantly related to negative symptoms, although only paternal age remained significantly associated with the treatment response in analyses that included both parents’ ages. Conclusions APA was associated with greater treatment response to both paliperidone ER and placebo, but not to age of onset or initial symptom severity in adolescents with schizophrenia. The results support the contention that APA-related schizophrenia has distinct underpinnings from other cases. Further studies are required to explore the role of genetic and environmental factors, and their interactions, in treatment response in this complex disorder.

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Section: Discussionmentioning

confidence: 93%

Effect of parental age on treatment response in adolescents with schizophrenia

Opler

Malaspina

Gopal

et al. 2013

Schizophrenia Research

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“…During the DB acute treatment period, patients were randomized (1:1 ratio) to receive once-daily paliperidone ER orally ( [5][6][7], flexibly dosed 5, 10, or 15 mg per day from day 8 to EOS). The randomization was based on a computer-generated randomization schedule balanced by using permuted blocks of treatments and stratified by center.…”

Section: Methodsmentioning

confidence: 99%

“…4 An earlier age of onset for schizophrenia, particularly prepubertal, is associated with a poorer prognosis and greater impact of the disease on personality and relationship development, cognitive functioning, educational and work attainment, and social functioning. 1,5 Moreover, adolescent-onset schizophrenia is a lifelong illness.…”

mentioning

confidence: 99%

Efficacy and Safety of Paliperidone Extended Release in Adolescents With Schizophrenia: A Randomized, Double-Blind Study

Savitz

Lane

Nuamah

et al. 2015

Journal of the American Academy of Child & Adolescent Psych

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“…When the disorder begins in early adolescence (under 18 years old) it is termed early onset schizophrenia (EOS), with some cases beginning even earlier (under 14 years old) and called child onset schizophrenia (COS) or very early onset schizophrenia (VEOS) [1][2][3] . EOS is a rare condition and it is estimated to account for less than 4% of the cases of schizophrenia 4 .…”

Section: Introductionmentioning

confidence: 99%

Thought and language disorders in very early onset schizophrenia, schizoaffective disorder and bipolar disorder

Pantano¹,

Fu²,

Curatolo³

et al. 2016

Arch. Clin. Psychiatry (São Paulo)

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Background: Thought and language disorders are main features of adults with schizophrenia and bipolar disorders however studies on such abnormalities are scant in young patients with very early onset psychosis (VEOS). The aim of the present study is to assess the relationship between language and thought disorders in patients with very early onset schizophrenia (SCZ), schizoaffective disorders (SCA) and bipolar disorders (BD). Method: Forty-one patients (18 SCZ, 16 BD, and 7 SCA) with mean age less than 15 years old were assessed through a series of neurocognitive and psycholinguistic tests, including the Thought, Language and Communication Scale (TLC). Results: SCZ group performed worse in all tests as well as the TLC, followed by SCA and BD groups respectively. Thought disorders were related to deficits in executive functioning and semantic processing, and the metaphors' test was the best predictor of TLC functioning. Discussion: TD in SCZ, SCA and BD are one of the most important features in patients with VEOS and that the evaluation of metaphor comprehension can be an important instrument in the early detection of this disorder.

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Treatment of early-onset schizophrenia

Cited by 40 publications

References 60 publications

Effect of parental age on treatment response in adolescents with schizophrenia

Effect of parental age on treatment response in adolescents with schizophrenia

Efficacy and Safety of Paliperidone Extended Release in Adolescents With Schizophrenia: A Randomized, Double-Blind Study

Thought and language disorders in very early onset schizophrenia, schizoaffective disorder and bipolar disorder

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