Treatment of Early Syphilis with Penicillin Alone

Jefferiss, F. J. G.; Willcox, R. R.

doi:10.1136/sti.39.3.143

Sexually Transmitted Infections

1963

DOI: 10.1136/sti.39.3.143

|View full text |Cite

Treatment of Early Syphilis with Penicillin Alone

F. J. G. Jefferiss¹,

R. R. Willcox²

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1964

2014

Publication Types

Select...

Article6

Relationship

Self Cite0

Independent6

Authors

Journals

Cited by 9 publications

(1 citation statement)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies in the 1940s and 50s involving thousands of patients clearly demonstrated the utility of penicillin for syphilis therapy, however, methodological limitations, which included mixed regimens of penicillin and arsenicals, make application of these data to present-day care difficult [3,[5][6][7]. Nonetheless, supported by those trials as well as years of experience, benzathine penicillin G has become the mainstay of therapy in the USA for early syphilis treatment.…”

mentioning

confidence: 98%

Clinical management of early syphilis

Holman¹,

Hook

2013

Expert Review of Anti-infective Therapy

View full text Add to dashboard Cite

Early syphilis therapy was a focus of intense research in the early 20th century with many and varied approaches being used. The development of penicillin and its efficacy in the treatment of syphilis transformed syphilis management for many with and at risk for infection. However, problems such as beta-lactam allergies and the desire for easily administered, alternate therapies have led to evaluation of multiple other drugs, with doxycycline currently recommended as the main alternative. Ceftriaxone and azithromycin have been shown to be effective, however, each has its own difficulties. Follow-up relies on serological testing, leading to concerns when these tests do not decline appropriately. Given concerns about the potential for increased risk for treatment failure, patients with HIV and pregnant women are of particular concern.

show abstract

mentioning

confidence: 98%

Clinical management of early syphilis

Holman¹,

Hook

2013

Expert Review of Anti-infective Therapy

View full text Add to dashboard Cite

show abstract

Cephalexin Therapy for Infectious Syphilis

Duncan¹

1974

Arch Dermatol

View full text Add to dashboard Cite

Treatment of Syphilis

Clement

Okeke

Hicks

2014

JAMA

236

102

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Treatment of Early Syphilis with Penicillin Alone

Cited by 9 publications

References 4 publications

Clinical management of early syphilis

Clinical management of early syphilis

Cephalexin Therapy for Infectious Syphilis

Treatment of Syphilis

Contact Info

Product

Resources

About