Treatment of Early Venereal Syphilis with Antibiotics

Willcox, R. R.

doi:10.1136/sti.38.3.109

Cited by 7 publications

(4 citation statements)

References 56 publications

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“…Simon et a!20 confirmed these results in a study of 1 (table II) for both complexes; (e) the kinetics of elimination of both complexes were comparable in young subjects while in elderly subjects the benethamine penicillin complex followed a slower kinetic of elimination giving higher penicillin concentrations in serum for a longer period than the benzathine penicillin complex; and (f) treatment regimens based solely on the number of international units of penicillin were precarious if the properties of the chosen salts of penicillin were not taken into account.…”

Section: Discussionmentioning

confidence: 68%

Kinetic study of serum penicillin concentrations after single doses of benzathine and benethamine penicillins in young and old people.

Collart¹,

Poitevin²,

Milovanović³

et al. 1980

Sexually Transmitted Infections

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SUMMARY In a comparative kinetic study of the serum concentrations of two penicillin complexes-medium-long-acting (benethamine penicillin) and long-acting (benzathine bipenicillin)-after a single injection in young adults and elderly people, the following results were confirmed statistically: (a) age was a major factor in the variations in serum penicillin concentrations and in their persistence in the serum; (b) the penicillin was absorbed faster in young than in elderly subjects even when a long-acting complex was used; (c) serum concentrations below the level regarded as lethal for treponemes appeared much earlier and more frequently in young than in old people; and (d) the bioequivalence between penicillin preparations could not be estimated solely from the number of units of the agent used but from the bioavailability of the chosen formulation.Thus a uniform and standard penicillin dosage allowing no safety margin may help in the superficial healing of a syphilitic chancre or the resolution of a roseola but it will certainly be insufficient to kill Treponema pallidum. It seems essential therefore to provide an antibiotic cover at high dosage over a long period of time.

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Section: Discussionmentioning

confidence: 68%

Kinetic study of serum penicillin concentrations after single doses of benzathine and benethamine penicillins in young and old people.

Collart¹,

Poitevin²,

Milovanović³

et al. 1980

Sexually Transmitted Infections

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“…Moreover, 90 days is not a long follow-up period for syphilis, as Schroeter and others acknowledge, and the possibility that the larger dosage prolonged the incubation period in some cases without eliminating all the treponemes cannot be wholly excluded. Willcox (1962) held that the concentration of penicillin achieved in the blood is less important than the duration of the penicillinaemia. He believed that even small doses of penicillin aluminium monostearate would completely abort incubating syphilis, but pointed out that the various preparations varied in efficacy-a fact which may help to explain the occurrence of syphilis after 1-2 m.u.…”

Section: Discussionmentioning

confidence: 99%

Letter: Effect on incubating syphilis of penicillin treatment for gonorrhoea.

Campbell¹

1974

Sexually Transmitted Infections

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“…Os seus trabalhos comprovaram a eficácia do medicamento 72 naquela doença e constituíram o ponto de partida para o desenvolvimento de outros estudos sobre doenças venéreas 73 . Com a institucionalização da penicilina no tratamento da sífilis decresceu a sua prevalência 74 77 .…”

Section: A Introdução Da Penicilina Na Terapêutica Medicamentosa: Suaunclassified

Mente sã em corpo são: exercícios, alimento e saúde nas páginas do Anuário das Senhoras durante o Estado Novo Brasileiro (1937-1945)

Pilla

2019

RPH

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A navegação consulta e descarregamento dos títulos inseridos nas Bibliotecas Digitais UC Digitalis, UC Pombalina e UC Impactum, pressupõem a aceitação plena e sem reservas dos Termos e Condições de Uso destas Bibliotecas Digitais, disponíveis em https://digitalis.uc.pt/pt-pt/termos.Conforme exposto nos referidos Termos e Condições de Uso, o descarregamento de títulos de acesso restrito requer uma licença válida de autorização devendo o utilizador aceder ao(s) documento(s) a partir de um endereço de IP da instituição detentora da supramencionada licença.Ao utilizador é apenas permitido o descarregamento para uso pessoal, pelo que o emprego do(s) título(s) descarregado(s) para outro fim, designadamente comercial, carece de autorização do respetivo autor ou editor da obra.Na medida em que todas as obras da UC Digitalis se encontram protegidas pelo Código do Direito de Autor e Direitos Conexos e demais legislação aplicável, toda a cópia, parcial ou total, deste documento, nos casos em que é legalmente admitida, deverá conter ou fazer-se acompanhar por este aviso.Medicamentos e vida privada na primeira metade do século xx: o combate às infeções antes e depois da penicilina Autor(es):Bell, Victoria Abstract:Private and daily life is deeply associated with medicaments. Public and private health issues intersect within the medical subject of infectious disease. In order to resolve these issues social initiatives or medical treatments can be used. The first two parts of this article will evaluate the drugs used to fight infectious diseases related with private life and the way in which these drugs, especially mercurial and arsenical compounds, were regarded. This study is based upon renowned hygiene and medicament therapy studies from the early twentieth century, such as:

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Treatment of Early Venereal Syphilis with Antibiotics

Cited by 7 publications

References 56 publications

Kinetic study of serum penicillin concentrations after single doses of benzathine and benethamine penicillins in young and old people.

Kinetic study of serum penicillin concentrations after single doses of benzathine and benethamine penicillins in young and old people.

Letter: Effect on incubating syphilis of penicillin treatment for gonorrhoea.

Mente sã em corpo são: exercícios, alimento e saúde nas páginas do Anuário das Senhoras durante o Estado Novo Brasileiro (1937-1945)

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