Treatment of eccrine porocarcinoma with Mohs micrographic surgery: a cases series and literature review

Tidwell, W. James; Mayer, Jonathan E.; Malone, Janine C.; Schadt, Courtney R.; Brown, Timothy S.

doi:10.1111/ijd.12997

Cited by 18 publications

(16 citation statements)

References 29 publications

(67 reference statements)

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“…Histopathological findings of EP reveal broad anastomosing bands extending from the epidermis to dermis and cuboidal tumor cells with basophilic nuclei. An EP lesion can be differentiated from the malignant EPC by a lack of mitotic activity, infiltrative growth pattern, spontaneous tumor necrosis, cytologic atypia, extensive clear cell differentiation, perineural, or vascular invasion 17‐20 …”

Section: Introductionmentioning

confidence: 99%

Eccrine porocarcinoma of the head and neck: Meta‐analysis of 120 cases

Janik

Liu

et al. 2020

Head & Neck

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Background The aim of the study is to analyze potential prognostic factors and to evaluate therapy strategies regarding clinical outcome in patients with eccrine porocarcinoma (EPC) of the head and neck. Methods One hundred and sixteen EPC cases from ninety studies and four authors' EPC cases were included in the meta‐analysis. Results At an average follow up of 20.48 months, the 3‐year overall survival and regional recurrence rate were 70.3% and 19.0%, respectively. Patients without surgical treatment had a significantly worse 3‐year overall survival. Mohs microscopic surgery led to significantly less occurrence of regional recurrences compared to wide excision. An ulcerating lesion, high mitotic activity, and lymphovascular invasion were significant prognostic factors. Conclusion Surgical resection is the cornerstone in the therapy of EPC and represents the therapeutic modality that offers the best chance of disease‐free survival. Due to the high probability of recurrence, close follow‐ups are strongly recommended.

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Section: Introductionmentioning

confidence: 99%

Eccrine porocarcinoma of the head and neck: Meta‐analysis of 120 cases

Janik

Liu

et al. 2020

Head & Neck

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“…There are no large studies comparing WLE with MMS in EPC. Although it has been suggested by some authors that MMS outcomes could be better than WLE, many surgeons prefer to treat EPC with WLE [13][14][15].…”

Section: Eccrine Porocarcinoma (Epc)mentioning

confidence: 99%

3 Mohs Micrographic Surgery

2018

Facial Reconstruction After Mohs Surgery

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Mohs micrographic surgery (MMS) is used to obtain clear margins in skin cancer treatment. MMS involves staged excisions and complete margin assessment of the specimen from fresh tissue frozen sectioning. It has been shown to achieve higher cure rates with malignancies, including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), lentigo maligna, melanoma in situ and dermatofibrosarcoma protuberans. This technique is especially useful in face, feet and hand regions to avoid cosmetic deformities.

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“…[1][2][3][4] Mohs micrographic surgery (MMS) has been well established in the management of several sweat gland malignancies. [5][6][7] To our knowledge, the use of MMS for ADPA has not been previously reported; however, nomenclature has been inconsistent. Dhawan and colleagues reported a case of MMS for an apocrine adenocarcinoma on the finger with similar histologic description but without formal ADPA diagnosis.…”

Section: Introductionmentioning

confidence: 99%