Treatment of Endometriosis

Olive, David L.; Pritts, Elizabeth A.

doi:10.1056/nejm200107263450407

Cited by 337 publications

(247 citation statements)

References 75 publications

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“…The prevalence of endometriosis has been estimated as up to 10% to 15% of reproductive-age women and 30% -50% of women with endometriosis have infertility (Verkauf 1987;Olive and Pritts 2001). Multiple factors are considered to contribute to endometriosis related infertility, including altered folliculogenesis, impaired fertilization, poor oocyte quality, and defective implantation.…”

Section: Hox Genes and Endometriosismentioning

confidence: 99%

The Role ofHoxGenes in Female Reproductive Tract Development, Adult Function, and Fertility

Taylor

2015

Cold Spring Harb Perspect Med

200

158

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HOX genes convey positional identity that leads to the proper partitioning and adult identity of the female reproductive track. Abnormalities in reproductive tract development can be caused by HOX gene mutations or altered HOX gene expression. Diethylstilbestrol (DES) and other endocrine disruptors cause Mü llerian defects by changing HOX gene expression. HOX genes are also essential regulators of adult endometrial development. Regulated HOXA10 and HOXA11 expression is necessary for endometrial receptivity; decreased HOXA10 or HOXA11 expression leads to decreased implantation rates. Alternation of HOXA10 and HOXA11 expression has been identified as a mechanism of the decreased implantation associated with endometriosis, polycystic ovarian syndrome, leiomyoma, polyps, adenomyosis, and hydrosalpinx. Alteration of HOX gene expression causes both uterine developmental abnormalities and impaired adult endometrial development that prevent implantation and lead to female infertility.

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Section: Hox Genes and Endometriosismentioning

confidence: 99%

The Role ofHoxGenes in Female Reproductive Tract Development, Adult Function, and Fertility

Taylor

2015

Cold Spring Harb Perspect Med

200

158

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“…Endometriosis is a very common gynecological disorder, which is estrogen dependent as well as inflammatory in nature, prevalent in 10-15% of reproductive aged women (Olive & Pritts 2001). This disease is associated with chronic pelvic pain as well as infertility.…”

Section: Endometriosismentioning

confidence: 99%

Expression, activation, and role of AKT isoforms in the uterus

Fabi¹,

Asselin²

2014

Reproduction

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The three isoforms of AKT: AKT1, AKT2, and AKT3, are crucial regulators of both normal and pathological cellular processes. Each of these isoforms exhibits a high level of homology and functional redundancy with each other. However, while being highly similar and structurally homologous, a rising amount of evidence is showing that each isoform possesses specific targets as well as preferential subcellular localization. The role of AKT has been studied extensively in reproductive processes, but isoform-specific roles are yet to be fully understood. This review will focus on the role of AKT in the uterus and its function in processes related to cell death and proliferation such as embryo implantation, decidualization, endometriosis, and endometrial cancer in an isoform-centric manner. In this review, we will cover the activation of AKT in various settings, localization of isoforms in subcellular compartments, and the effect of isoform expression on cellular processes. To fully understand the dynamic molecular processes taking place in the uterus, it is crucial that we better understand the physiological role of AKT isoforms as well as their function in the emergence of diseases.Reproduction (2014) 148 R85-R95

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“…Sus principales manifestaciones clínicas incluyen dolor pélvico, en general asociado a la menstruación, infertilidad, dispareunia y dismenorrea (1,(7)(8)(9) . Cuando existe compromiso del tracto gastrointestinal, puede manifestarse por dolor abdominal difuso, dolor rectal, náuseas, vómitos, diarrea, constipación, tenesmo y hemorragia digestiva baja.…”

Section: Caso Radiologico Para Diagnostico Resultado Caso Clinico Radunclassified

Dolor Colico Y Distension Abdominal

Avaria¹,

O'Brien

2008

Rev. chil. radiol.

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Treatment of Endometriosis

Cited by 337 publications

References 75 publications

The Role ofHoxGenes in Female Reproductive Tract Development, Adult Function, and Fertility

The Role ofHoxGenes in Female Reproductive Tract Development, Adult Function, and Fertility

Expression, activation, and role of AKT isoforms in the uterus

Dolor Colico Y Distension Abdominal

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