Treatment of Eosinophilic Annular Erythema With Benralizumab

Abstract

This case report describes an 83-year-old woman with a generalized pruritic eruption comprising annular and polycyclic plaques on the face, neck, trunk, and extremities with changing appearance.

Eosinophilic Annular Erythema Responding to Doxycycline

“…Although EAE is typically considered a benign condition with a good prognosis, the relapsing and remitting cycles and associated patient discomfort warrant a therapeutic attempt. Moreover, there is some postulation of systemic implications of EAE, with cases of concomitant autoimmune disease, cancer, and vasculitis being reported in the literature [1,6]. Given there is no standard treatment for this condition, several options have been reported including hydroxychloroquine, systemic corticosteroids, topical steroids, narrow-band UVB, dapsone, and dupilumab [1,7].…”

“…Moreover, there is some postulation of systemic implications of EAE, with cases of concomitant autoimmune disease, cancer, and vasculitis being reported in the literature [1,6]. Given there is no standard treatment for this condition, several options have been reported including hydroxychloroquine, systemic corticosteroids, topical steroids, narrow-band UVB, dapsone, and dupilumab [1,7]. To our knowledge, no cases of EAE improving with doxycycline have been reported in the literature.…”

“…Eosinophilic annular erythema (EAE) is a rare skin disease characterized by relapsing and remitting pruritic, annular erythematous plaques and tissue eosinophilia. Approximately 60 cases have been cited in the literature [1]. The pathogenesis of EAE is poorly understood.…”