Treatment of equine cutaneous neoplasia by radiotherapy using iridium 192 linear sources

Wyn‐Jones, G.

doi:10.1111/j.2042-3306.1983.tb01824.x

Cited by 54 publications

(17 citation statements)

References 8 publications

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“…Reported therapies for ocular and periocular SCC (PSCC) include surgical excision, 10,14 cryotherapy, 15,16 immunotherapy, 22,23 radiofrequency hyperthermia, 18,23 topical or intratumoral chemotherapy, 19 carbon dioxide laser ablation, 24 and several radiation therapies 8,17,20,21,23,25–30 . Tumor recurrence is frequently reported following surgical excision and ancillary therapy because it is often not possible to achieve satisfactory excisional margins and the additional therapies fail to successfully eliminate residual tumor cells.…”

Section: Introductionmentioning

confidence: 99%

Photodynamic therapy for the treatment of periocular squamous cell carcinoma in horses: a pilot study

Giuliano

MacDonald

McCaw

et al. 2008

Veterinary Ophthalmology

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Objective Local photodynamic therapy (PDT) is a novel cancer therapy in veterinary ophthalmology. A prospective pilot study seeking to demonstrate proof of principle and safety for the treatment of equine periocular squamous cell carcinoma (PSCC) was therefore conducted. We hypothesized that surgical excision with adjunctive local PDT is an effective and safe treatment for equine PSCC. Procedures Nine horses (10 eyes) with PSCC were treated with surgical resection, local infiltration of resulting wound beds with 2-[1-hexyloxyethyl]-2-devinylpyropheophorbide-a (HPPH) and irradiation with 665-nm wavelength diode laser. Regular follow-up ophthalmic examinations were performed. Results Surgical resection and PDT yielded disease-free intervals of 25-68 months in our study horses as of January, 2008. These results were obtained following a single treatment in seven horses and two treatments in one horse. In one horse, carcinoma in situ developed 2.5 months after partial surgical excision and PDT, requiring local excision under standing sedation. Conclusions Preliminary results suggest that surgical resection and adjunctive local PDT is a safe and effective novel treatment for PSCC in horses. More research is needed before PDT for the treatment of equine PSCC can be adequately compared with other current modalities. Important to future investigations regarding PDT, tumor recurrence rate, length of hospitalization, number of treatment episodes required to effect tumor remission, and total treatment costs should be examined in a controlled manner. Our present results and experiences suggest that this treatment may be useful in the treatment of equine PSCC.

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Section: Introductionmentioning

confidence: 99%

Photodynamic therapy for the treatment of periocular squamous cell carcinoma in horses: a pilot study

Giuliano

MacDonald

McCaw

et al. 2008

Veterinary Ophthalmology

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“…Predilection sites are the nictitating membrane/nasal canthus, limbus, and eyelid 7 . Various treatment modalities have been proposed for equine SCC including surgical resection, 4,8 cryotherapy, 5,9 radiofrequency hyperthermia, 10 immunotherapy, 11 intralesional cisplatin, 12 carbon dioxide laser ablation, 13 radiation therapy (both Strontium 90 plesiotherapy, 14,15 and interstitial radiotherapy 16,17 ), and combinations of these 18,19 …”

Section: Introductionmentioning

confidence: 99%

Expression of cyclooxygenase‐2 by equine ocular and adnexal squamous cell carcinomas

Smith¹,

Scase

Miller

et al. 2008

Veterinary Ophthalmology

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Objective : To investigate whether cyclooxygenase-2 (COX-2) is expressed by equine ocular and adnexal squamous cell carcinomas (SCC). Methods : Forty-three samples of histologically confirmed cases of ocular SCC or carcinoma in situ (CIS) from 34 horses presented to the Animal Health Trust between 1992 and 2004 were subjected to a standard, two-layered, indirect immunohistochemical method using a rabbit polyclonal antihuman COX-2 antibody. Ten formalin-fixed, paraffin-embedded tissue samples taken from recognized predilection sites for SCC, from the grossly normal eyes of 10 horses euthanized for reasons unrelated to this study, were used as negative controls. Samples of equine fetal kidney were used as positive controls. Following immunolabeling, the number of normal and neoplastic epithelial cells exhibiting positive COX-2 expression was recorded along with staining intensity and distribution. Results : Of 43 tumors, 34 were defined as first presentation tumors. When compared with control tissue, in which 0% (0/10) of samples expressed COX-2, significantly more of these samples with SCC (58.6%, 17/29: P = 0.002), CIS (60%, 3/5: P = 0.022) or either tumor type (58.8%, 20/34: P = 0.001) exhibited positive cytoplasmic and perinuclear immunohistochemical staining for COX-2. Of the samples exhibiting positive immunohistochemical staining, only 10% (2/20) showed staining in 2%-10% of neoplastic cells, while 90% (18/20) showed staining in ≤ 1% of neoplastic cells. About 70% (14/20) of those positively immunolabeled samples exhibited an intensity of staining greater than or equal to the staining exhibited by the equine fetal kidney positive control. Conclusion : Neoplastic tissue from both equine ocular SCC and CIS exhibit COX-2 expression at significantly higher levels than normal control ocular tissue. However, the percentage of cells expressing positive immunohistochemical staining is consistently low. On the basis of this study, it is unlikely that anti-COX-2 therapy would be of benefit in the treatment of equine ocular and adnexal SCC.

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“…Radiotherapy as a treatment for equine tumours, has been previously reported (Frauenfelder et al . , b; Wyn‐Jones ; Byam‐Cook et al . ; Montgomery ; Hollis ) but is infrequently used due to the necessity for special equipment and concerns regarding management of patients receiving radiotherapy (Van Den Top et al .…”

Section: Discussionmentioning

confidence: 99%

Surgical resection of a squamous cell carcinoma in the perianal region of a 25‐year‐old crossbred American Paint gelding using sharp surgical excision, laser excision and chemotherapy

Poore

Smit

Duncan

et al. 2018

Equine Veterinary Education

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Summary A 25 year‐old American Paint gelding was referred to the Onderstepoort Academic Veterinary Hospital with an ulcerated lesion of nonpigmented skin at the right lateral aspect of the perianal region. An infiltrating squamous cell carcinoma was suspected. Surgical excision and ablation with sharp surgical excision and a diode laser was performed although complete excision was not possible due to the tumour location. Intralesional chemotherapy was performed at the completion of the surgical excision and continued in the post‐operative period. Histological examination of the excised lesion confirmed a diagnosis of squamous cell carcinoma and revealed incomplete resection margins at the medial, dorsal and ventral aspects of the surgical site. The surgical site healed uneventfully and a re‐examination at 6 months post‐surgery revealed the gelding to have normal clinical parameters with no perianal lesions.

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Treatment of equine cutaneous neoplasia by radiotherapy using iridium 192 linear sources

Cited by 54 publications

References 8 publications

Photodynamic therapy for the treatment of periocular squamous cell carcinoma in horses: a pilot study

Photodynamic therapy for the treatment of periocular squamous cell carcinoma in horses: a pilot study

Expression of cyclooxygenase‐2 by equine ocular and adnexal squamous cell carcinomas

Surgical resection of a squamous cell carcinoma in the perianal region of a 25‐year‐old crossbred American Paint gelding using sharp surgical excision, laser excision and chemotherapy

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