Treatment of erosive oral lichen planus with methotrexate

Abstract

Methotrexate is a valuable therapeutic option in longstanding recalcitrant EOLP, particularly with respect to the improvement of subjective symptoms. Randomized controlled trials are required.

Lichen planus pemphigoides

“…Inflammatory basal cell layer damage may expose antigens or produce neoantigens, thus leading to autoantibody production (epitope spreading); this explains the simultaneous occurrence of bullae on normal skin and in LP lesions [4,7,8]. Drugs such as acitretin or methotrexate are capable of suppressing the lichenoid reaction by modulating inflammation and, possibly, by silencing the implicated triggering factor [1,9]. In the present case, a single course of prednisolone was sufficient to treat both lichen planus and LPP.…”

Porokeratotic lichen planus

“…Lichen planus is a common papulosquamous inflammatory dermatosis of unknown etiology that presents in a number of morphologic patterns and clinical variants [1][2][3] and can involve the skin, mucosa and hair as well as the nails [4]. Porokeratosis is a clonal disorder of keratinization that manifests clinically as centrifugally expanding, annular plaque(s) with a ridge-like margin -the cornoid lamella.…”

A study of cytokine content in the blood serum of patients with lichen ruber planus

“…"The authors declare no conflict of interest regarding this article" "The authors declare that all the procedures and experiments of this study respect the ethical standards in the Helsinki Declaration of 1975, as revised in 2008 (5), as well as the national law. Informed consent was obtained from all the patients included in the study"…”

“…According to clinical observations, this dermatosis is characterized by widespread skin lesions and lesions of the mucous membranes of the mouth and genitals, severe itching, protracted clinical course, the formation of resistance to treatment in patients, which has a negative effect on the psycho-emotional state of the patients, reduces their ability to work and social activity [3][4][5][6] . Therefore, an important task of modern dermatology is to study the pathogenetic factors of the complicated clinical course of LRP and optimization of its treatment [7][8][9] .…”