Treatment of Essential Hypertension with Combined Vasodilation and Beta-Adrenergic Blockade

Zacest, R.; Gilmore, Edward D.; Koch‐Weser, Jan

doi:10.1056/nejm197203232861201

Cited by 275 publications

(72 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This provided a maximum estimate of AUC after oral administration. 1 7 All BP values were expressed as mean arterial pressure (MAP), which was calculated as diastolic pressure plus 1/3 pulse pressure.…”

Section: Analysis Of Datamentioning

confidence: 99%

“…When used in combination with a diuretic and beta blocker, it has been shown to be effective in patients resistant to prior therapy. 1 However, examples of inadequate blood pressure (BP) responses to regimens that include hydralazine are not infrequent. 1 …”

mentioning

confidence: 99%

“…1 However, examples of inadequate blood pressure (BP) responses to regimens that include hydralazine are not infrequent. 1 …”

mentioning

confidence: 99%

See 2 more Smart Citations

Plasma concentration and acetylator phenotype determine response to oral hydralazine.

Shepherd¹,

McNay

Ludden

et al. 1981

Hypertension

View full text Add to dashboard Cite

SUMMARYThe vasodepressor response to single and multiple oral doses of hydralazine, 1 mg/kg, was studied in hypertensive patients. The concentration of bydralazbe in plasma was measured both by a newly developed specific and a nonspecific assay similar to those used in previous studies. Acetylator phenotype was determined following oral sulfamethazine. Plasma hydralazine concentration peaked at 1 hour after administration and was undetectable 2 hours later. Apparent hydralazine was present in plasma in higher concentration and for a longer duration than hydralazine. The peak decreases in blood pressure (BP) were proportional to plasma hydralazine concentration following administration of both single and multiple doses and were substantially maintained for 8 hours.

show abstract

Section: Analysis Of Datamentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Plasma concentration and acetylator phenotype determine response to oral hydralazine.

Shepherd¹,

McNay

Ludden

et al. 1981

Hypertension

View full text Add to dashboard Cite

show abstract

“…Plasma renin activity was unexpectedly lower throughout the day of PR-G 138 administration than during the previous control period. Absence of a rise in plasma renin activity has also been noticed after administration of another vasodilating hypotensive agent, prazosin (Zacest et al, 1973). As shown in Table 4 PRA values 3 h after PR-G 138 administration rose slightly in four of the seven subjects studied, whereas on the control day a decrease was noticed in every patient as a result of the diurnal rhythm.…”

Section: Dskonmentioning

confidence: 68%

“…As these side-effects are probably inherent in the mode of action of any vasodilating drug and may be prevented by f-adrenergic recptor blockade, (Zacest et al, 1973;O'Malley, Velsco, Wells & McNay, 1975), we have given our patients propranolol treatment throughout the study.…”

mentioning

confidence: 99%