Treatment of Ethylene Glycol Poisoning with Oral Ethyl Alcohol

Abstract

Ethylene glycol poisoning is not uncommon in India. The ill effects are primarily caused by its toxic metabolites: glycolic acid and oxalic acid. A 70-year-old female presented to our hospital with ataxia after ingestion of ethylene glycol. The reported case describes the management of ethylene glycol poisoning using oral ethyl alcohol as an alternative to the recommended intravenous ethyl alcohol and fomepizole that are not available for use in India. The need for high degree of clinical suspicion, targeted investigations, and early instigation of treatment is of prime importance in cases of ethylene glycol poisoning as it can lead to long-term complications or even death.

Anion gap‐opening metabolic acidosis and urinary findings in the early diagnosis of ethylene glycol poisoning: A case report

“…Since there is no direct comparison between the effects of ethanol and fomepizole and evidence to support their use, some studies suggest that the decision should be based on the availability and cost of the antidote, the hemodialysis facility, patient characteristics, and the physician's experience with the particular antidote. 11 However, oral ethanol has also been used because obtaining fomepizole and the off‐label use of intravenous ethanol are difficult. 12 , 13 In the United States, fomepizole is used at a higher rate.…”

Curtailment of Nephrotoxicity of Polyethylene Glycol via Moringa Oleifera Leaf Extract in Male Rats

“…Moringa oleifera Lam. is one of the most famous ancient if it is possible to prevent or reduce PEG oxidation, to prevent or reduce PEG toxicity (Achappa et al, 2019). So, the frequent exposure to a high dose of PEG shows toxic activity and causes tissue changes in kidney of mice, because of that, the world health organization (WHO) has determined that Quantity daily allowed 10 mg/kg from PEG.…”