Treatment of extensive virus warts with etretinate (Tigason) in a patient with sarcoidosis

Boyle, J.; Dick, D. C.; MacKie, Rona M.

doi:10.1111/j.1365-2230.1983.tb01741.x

Cited by 39 publications

(17 citation statements)

References 6 publications

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“…187 Other trials and case reports have shown systemic retinoids, especially synthetic isotretinoin, to have an effect on a variety of warts, particularly genital warts. [188][189][190][191] A great deal of interest has been expressed in the use of retinoids as a potential chemopreventive and/or therapy in HPV-related cervical cancer. 192 …”

Section: Antimitotic Therapymentioning

confidence: 99%

An Armamentarium of Wart Treatments

Lipke¹

2006

Clinical Medicine & Research

287

295

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Patients and clinicians experience the frustration of cutaneous viral warts caused by infection with the human papilloma virus (HPV).Warts appear in various forms on different sites of the body and include common warts (verruca vulgaris), plane or flat warts, myrmecia, plantar warts, coalesced mosaic warts, filiform warts, periungual warts, anogenital warts (venereal or condyloma acuminata), oral warts and respiratory papillomas. Cervical infection with HPV is now known to cause cervical cancer if untreated. A review of the medical literature reveals a huge armamentarium of wart monotherapies and combination therapies. Official evidence-based guidelines exist for the treatment of warts, but very few of the reported treatments have been tested by rigorous blinded, randomized controlled trials.Therefore, official recommendations do not often include treatments with reportedly high success rates, but they should not be ignored when considering treatment options. It is the purpose of this review to provide a comprehensive overview of the wart treatment literature to expand awareness of the options available to practitioners faced with patients presenting with problematic warts. Warts of the genital tract carry a much more ominous and pernicious threat for women in particular. It has been estimated that up to 70% of sexually active women become infected during their lifetime with human papillomavirus (HPV), the infective agent that causes warts. 3-5 A causal role for HPV infections in cervical cancer has been documented beyond reasonable doubt. HPV DNA is present in virtually all cervical cancer cases worldwide, with it being detected in 99.7% of an international series of cervical cancers by genetic amplification techniques and in 100% of cases as confirmed by histological review. 6,7 Cervical cancer is the most frequent common cancer in developing countries and the second most common cancer in women worldwide. 3 The association between HPV infection and cervical cancer is so strong that HPV is now considered the first positive cause of any human cancer ever identified. 3This raises the level of concerns over HPV prevention, screening and treatment from that of a nuisance condition to that of a major public health concern. Attention is beginning to focus on the viral factors that determine persistence and neoplastic progression to cancer and the possible role of HPV in other nongenital cancers (e.g., skin, upper aerodigestive tract). [8][9][10][11][12][13][14][15][16][17] Patients with warts seek advice from general practitioners, pharmacists, naturopaths, allied health professionals, family or friends, dermatologists, gynecologists, obstetricians and pediatricians for treatment and may present with recalcitrant warts that have been previously treated with anything from folk remedies to hypnosis to over-the-counter medications to more aggressive clinic-based treatments. Unfortunately, even with years of medical literature on this subject, high-quality, level I evidence for the efficacy of almost all treatments is no...

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Section: Antimitotic Therapymentioning

confidence: 99%

An Armamentarium of Wart Treatments

Lipke¹

2006

Clinical Medicine & Research

287

295

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“…Fi nally, we found a promising effect in Behçet's disease, which manifested itself in the rapid healing of, for example, cutaneous ul cerations [26]. Finally, etretinate was found to be effective in the treatment of extensive warts in immunocompromised patients [27] and in granuloma annulare disseminatum [28].…”

Section: Etretinatementioning

confidence: 99%

New Indications and New Retinoids

Gollnick¹

1987

Dermatology

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In addition to well-accepted indications, etretinate has a beneficial effect in a variety of other dermatoses such as the hyperkeratotic eczema of the palms and soles, prurigo nodularis, and other nonpsoriatic, sterile, pustular eruptions. Due to its influence on dermal inflammatory processes and immunomodulation of the tissue response, etretinate is effective in cutaneous lupus erythematosus, certain bullous disorders like pemphigus herpetiformis, the persistent variant of Grover’s disease, dermatitis herpetiformis, and bullous pemphigoid. Isotretinoin is reported to be effective in cutaneous sarcoidosis, disseminated granuloma annulare, systemic sclerosis and tumors of the cutaneous appendages. New synthetic retinoids have been developed. Etretin, the main metabolite of etretinate, was shown to be effective and to have a short elimination half-life of – 50 h. Arotinoid ethyl ester and arotinoid-free carboxylic acid are effective in minimal doses 500-fold lower than etretinate. Arotinoid ethyl ester was shown not to increase serum lipids. Arotinoid ethyl sulfone is the first retinoid without bone toxicity in animal experiments. Motretinide is the ethylamide of tretinoin and is reported to be effective in the local treatment of acne. Some of the new poly-aromatic retinoids appear to have sebosuppressive, antikeratinizing and/or anti-inflammatory effects via topical application.

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“…In many cases warts are recalcitrant despite multiple therapeutic efforts with: cryothera py [1], electrosurgery [2], keratolytics [3], cytostatics [4,5], antiviral agents [6], hypno sis [7], ultrasound [8], alpha-mercaptopropionilglycine [9], methionine [10], Xray therapy [11], laser [12], photodynamic inactivation [13], levamisole [14], interferon [15] and etretinate [16].…”

Section: Introductionmentioning

confidence: 99%

Treatment of Multiple Relapsing Warts with Diphenciprone

Orecchia

Douville²,

Santagostino³

et al. 1988

Dermatology

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44 patients with multiple recalcitrant warts were treated with weekly applications of diphencyprone. 20 patients were cured completely and 17 improved with reduction in the number or dimension of warts. Plantar warts responded less satisfactorily. Sensitization is not always tolerated by patients and the risk of eczema spreading to other sites must be considered. However, topical immunotherapy has to be considered as an alternative means of treatment in selected patients. The mode of action is discussed.

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Treatment of extensive virus warts with etretinate (Tigason) in a patient with sarcoidosis

Cited by 39 publications

References 6 publications

An Armamentarium of Wart Treatments

An Armamentarium of Wart Treatments

New Indications and New Retinoids

Treatment of Multiple Relapsing Warts with Diphenciprone

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