Treatment of exudative age‐related macular degeneration with aflibercept combined with pranoprofen eye drops or nutraceutical support with omega‐3: A randomized trial

Semeraro, Francesco; Gambicordi, Elena; Cancarini, Anna; Morescalchi, Francesco; Costagliola, Ciro; Russo, Andrea

doi:10.1111/bcp.13871

Cited by 17 publications

(7 citation statements)

References 31 publications

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“…After 12 months of treatment, results showed that compared with AM, each combination group showed an improvement, although no significant benefits in BCVA were found over AM. More specifically, nutraceutical support with omega-3 led to a decreased need for intravitreal injections [ 271 ]. Moreover, therapeutic intravitreal drug injections can be given only a few times per year, while nutraceuticals can be used on a daily basis, so that their presence in the organism and their function are continuous and may improve patients’ responses to therapy while also alleviating its side effects.…”

Section: Nutraceuticals: Which Place In the Management Of Neovascular...mentioning

confidence: 99%

Pharmacotherapy and Nutritional Supplements for Neovascular Eye Diseases

Rusciano

Bagnoli

2023

Medicina

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In this review, we aim to provide an overview of the recent findings about the treatment of neovascular retinal diseases. The use of conventional drugs and nutraceuticals endowed with antioxidant and anti-inflammatory properties that may support conventional therapies will be considered, with the final aim of achieving risk reduction (prevention) and outcome improvement (cooperation between treatments) of such sight-threatening proliferative retinopathies. For this purpose, we consider a medicinal product one that contains well-defined compound(s) with proven pharmacological and therapeutic effects, usually given for the treatment of full-blown diseases. Rarely are prescription drugs given for preventive purposes. A dietary supplement refers to a compound (often an extract or a mixture) used in the prevention or co-adjuvant treatment of a given pathology. However, it must be kept in mind that drug–supplement interactions may exist and might affect the efficacy of certain drug treatments. Moreover, the distinction between medicinal products and dietary supplements is not always straightforward. For instance, melatonin is formulated as a medicinal product for the treatment of sleep and behavioral problems; at low doses (usually below 1 mg), it is considered a nutraceutical, while at higher doses, it is sold as a psychotropic drug. Despite their lower status with respect to drugs, increasing evidence supports the notion of the beneficial effects of dietary supplements on proliferative retinopathies, a major cause of vision loss in the elderly. Therefore, we believe that, on a patient-by-patient basis, the administration of nutraceuticals, either alone or in association, could benefit many patients, delaying the progression of their disease and likely improving the efficacy of pharmaceutical drugs.

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Section: Nutraceuticals: Which Place In the Management Of Neovascular...mentioning

confidence: 99%

Pharmacotherapy and Nutritional Supplements for Neovascular Eye Diseases

Rusciano

Bagnoli

2023

Medicina

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“…It's reported that sodium hyaluronate eye drops may dilute the tear that naturally secreted by human body and stimulate the tear gland. The application of sodium hyaluronate eye drops can temporarily relieve symptoms of dry eye, but the efficacy was not significant (Rongfeng, 2019;Semeraro et al, 2019;Zhu et al, 2018). Pranoprofen eye drops play antibacteria and anti-allergy effect, with significant action of relieving discomfort symptoms in eyes.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2023

Pak. J. Pharm. Sci.,

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To study the therapeutic effect and clinical application value of pranoprofen eye drops combined with ultrasonic atomization in patients with diabetic dry eye. A total of 100 patients with diabetic dry eye who were admitted to our hospital from October 2018 to March 2020 were randomly selected and divided into control group and experimental group by lotting, with 50 patients in each group. The control group was treated with 0.1% sodium hyaluronate eye drops combined with ultrasonic atomization, while the experimental group received pranoprofen eye drops combined with ultrasonic atomization. SPEED score and SEEQ score in the experimental group were significantly lower than those in the control group, and the differences were statistically significant (P<0.05). The amount of basic tear secretion and tear film break-up time in the experimental group were significantly greater than those in the control group, with statistical significance (P<0.05). The response rate of the experimental group was significantly higher than that of the control group, with statistical difference (P<0.05). Pranoprofen eye drops combined with ultrasonic atomization can significantly improve the response rate of patients with diabetic dry eye, lower SPEED score and SEEQ score and improve the condition of basic tear secretion and tear film break-up.

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“…Such studies of course suffer from the problem that many different molecules are given at the same time and again would benefit from a more pharmacological mechanistic approach. 18 Clinical pharmacologists have to play a more important role in the development of these treatments than they do at present. We therefore hope that the number of ophtalmo-pharmacological submissions to BJCP will reflect that vision.…”

mentioning

confidence: 99%

“…Nutrition is not a medicine but the trial methodology similar especially when it is attempted to accomplish improvement of a condition like macular degeneration. Such studies of course suffer from the problem that many different molecules are given at the same time and again would benefit from a more pharmacological mechanistic approach 18 …”

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confidence: 99%