Treatment of Fungal Keratitis From Fusarium Infection by Corneal Cross-Linking

Galperín, Gustavo; Berra, Martín; Tau, Julia; Boscaro, Gabriela; Zárate, Jorge; Berra, Alejandro

doi:10.1097/ico.0b013e318221cec7

Cited by 79 publications

(52 citation statements)

References 19 publications

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“…This is due to enzymes that destroy tissues and antimicrobial proteins and the organisms' capacity to survive at high temperatures (37) . CXL acts on the anterior corneal stroma up until a depth of approximately 300 ìm (38) . Thus, deeper infectious corneal infiltrates may be less influenced by CXL.…”

Section: Discussionmentioning

confidence: 99%

Efeito terapêutico do crosslinking corneal na ceratite infecciosa

Escarião¹,

Ribeiro²,

Jorge³

et al. 2013

Rev. bras.oftalmol.

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Purpose:To evaluate the effect of corneal crosslinking (CXL) RESUMOObjetivo: Avaliar o efeito do crosslinking (CXL) no tratamento de ceratite infecciosa, resistente ao tratamento clínico, e investigar a relação com o agente etiológico. Métodos: Foram incluídos 11 pacientes com diagnóstico de ceratite infecciosa de etiologia bacteriana (sete olhos) e fúngica (quatro olhos) na Fundação Altino Ventura (FAV) no período de outubro de 2011 a maio de 2012. Os pacientes incluídos estavam em uso de colírios há pelo menos sete dias e não apresentavam melhora da infecção. Estes foram avaliados antes da realização do CXL e no período pós-operatório até cicatrização da úlcera. Para realização do CXL foram instiladas gotas de riboflavina a 0,1% e dextrano a 20%, a cada cinco minutos em um período de 30 minutos antes do procedimento, e durante a aplicação da luz ultravioleta A (UVA). A córnea foi exposta à UVA com comprimento de onda de 370ηm ± 5ηm e uma irradiância de 3mW/cm². Resultados: Os pacientes com infecção bacteriana obtiveram cura do processo infeccioso após o CXL e nenhum paciente com ceratite fúngica apresentou cicatrização. Observou-se associação significante (p = 0,003) entre o agente etiológico e a cicatrização. Conclusão: O CXL mostrou-se eficaz no tratamento da ceratite bacteriana resistente ao tratamento clínico, evitando a realização de transplante tectônico. Em relação à ceratite fúngica, este procedimento não influenciou na melhora do processo infeccioso.Descritores: Córnea; Reagentes para ligações cruzadas/uso terapêutico; Ceratite infecciosa/quimioterapia; Ceratite bacteriana/ quimioterapia; Ceratite fúngica/quimioterapia

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Section: Discussionmentioning

confidence: 99%

Efeito terapêutico do crosslinking corneal na ceratite infecciosa

Escarião¹,

Ribeiro²,

Jorge³

et al. 2013

Rev. bras.oftalmol.

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“…[9][10][11] The mechanisms of stopping the infectious and inflammatory processes in keratitis cases might include multiple synergistic effects, in addition to the inactivation of pathogens. It is known that enzymatic digestion is 1 of the mechanisms used by pathogens in infectious corneal melting.…”

Section: Discussionmentioning

confidence: 99%

“…Numerous case reports have shown the effect of CXL in refractory infectious keratitis. [9][10][11][12] The purpose of this report was to describe a case of Acremonium keratitis in a healthy woman who wore soft contact lenses daily and who was treated with CXL, voriconazole, and corneal transplant.…”

Section: Introductionmentioning

confidence: 99%

Untitled

Yağcı

Palamar²,

S³

et al. 2016

Exp Clin Transplant

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Objectives: To report a case of Acremonium keratitis treated with voriconazole, corneal collagen crosslinking, and corneal transplant. Materials and Methods: Case report. Results: A 42-year-old woman who wore contact lenses daily was referred for refractory keratitis. Her main complaints were gritty sensation and pain. At slit lamp biomicroscopy, an infiltrate on the inferior paracentral cornea and an arcuate conjunctival ulceration were evident. The rest of the cornea was clear with no anterior chamber reaction. Scrapings from the corneal ulcer showed Candida parapsilosis and Acremonium species, which were sensitive to voriconazole. Despite the administration of topical, systemic, and intrastromal voriconazole for 1 month, repeat corneal scraping was positive for Acremonium, and clinical appearance and pain did not resolve. Therefore, corneal collagen cross-linking was applied. Although the pain resolved immediately after the procedure, the lesion showed no improvement. After a month of cross-linking, corneal transplant was performed for visual rehabilitation and treatment of the refractory lesion. The excised corneal button was negative for any microorganisms. Conclusions: Although corneal collagen cross-linking may be an effective treatment for Acremonium keratitis refractory to medical therapy, corneal transplant was required for visual gain and recovery.

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“…In vivo после фотохимической терапии УФА и рибофлавином у кроликов с экспериментальным грибковым (Fusarium) кератитом отмечалось сни-жение показателей выраженности кератита, умень-шение количества гиф и клеток воспаления [22].…”

Section: кросслинкингunclassified

Modern treatments for purulent corneal ulcers

Kasparova¹

2016

Vestn. oftal'mol.

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Treatment of Fungal Keratitis From Fusarium Infection by Corneal Cross-Linking

Abstract: Treatment of fungal keratitis with CXL seems to be effective in decreasing the intensity and severity of infectious keratitis by F. solani. This therapy may be useful as a coadjuvant in the medical treatment of resistant infections.

Cited by 79 publications

References 19 publications

Efeito terapêutico do crosslinking corneal na ceratite infecciosa

Efeito terapêutico do crosslinking corneal na ceratite infecciosa

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Modern treatments for purulent corneal ulcers

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