Treatment of genital warts in men with potassium hydroxide

Loureiro, Walter Refkalefsky; Cação, F.M.; Belda, Walter; Fagundes, Luiz Jorge; Romiti, Ricardo

doi:10.1111/j.1365-2133.2007.08242.x

Cited by 10 publications

(13 citation statements)

References 3 publications

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“…Satisfactory outcomes of the use of KOH solutions in the treatment of molluscum contagiosum have led physicians to apply these solutions in the treatment of genital warts. Loureiro et al . reported that the 5% KOH solution was effective and safe in a trial including 35 men with external genital warts.…”

Section: Discussionmentioning

confidence: 99%

“…Hence, the most convenient therapeutic approach should be adopted for each patient . Several articles have reported the efficacy of potassium hydroxide (KOH) solution in molluscum contagiosum and genital warts . Although KOH solution appears to be an effective option for the treatment of genital warts, we were unable to find any studies in the literature in which it was compared with other effective therapies.…”

Section: Introductionmentioning

confidence: 95%

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A comparison of a 5% potassium hydroxide solution with a 5‐fluorouracil and salicylic acid combination in the treatment of patients with anogenital warts: a randomized, open‐label clinical trial

et al. 2014

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Anogenital warts are caused by human papillomavirus (HPV), over 30 types of which are infectious for the anogenital tract. Without treatment, warts may regress spontaneously, remain unchanged, or increase in number and size. This study compared the efficacy of a topical 5% potassium hydroxide (KOH) solution with that of a topical 0.5% 5‐fluorouracil (5‐FU) and 10% salicylic acid (SA) combination in the treatment of anogenital warts. Sixty patients were randomly assigned to receive topical KOH or 5‐FU + SA. Both groups demonstrated a significant decrease in numbers of lesions (P < 0.05), but this difference was not significant at week 12 (P > 0.05). The mean number of lesions decreased from baseline to week 12 from 17.03 ± 12.64 to 3.73 ± 7.30 and from 16.13 ± 12.97 to 3.10 ± 4.90 in the KOH and 5‐FU + SA groups, respectively (P < 0.001). Excellent clearance was achieved by 70.0 and 76.7% of patients in the KOH and 5‐FU + SA groups, respectively. Marked improvement was seen in 13.3 and 20.0% of patients in the KOH and 5‐FU + SA groups, respectively. At week 16, relapse was observed in two patients in the KOH group and three in the 5‐FU + SA group (P > 0.05). No serious adverse events were reported. Neither treatment was more efficacious. Safety and ease of application are important goals in treatments for anogenital warts. A 5% KOH solution is a promising alternative treatment because it is effective and inexpensive and causes minimal side effects.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

A comparison of a 5% potassium hydroxide solution with a 5‐fluorouracil and salicylic acid combination in the treatment of patients with anogenital warts: a randomized, open‐label clinical trial

et al. 2014

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“…[10] Nearly all therapeutic options are effective in some patients. [11] Therefore, a combination of different types of treatments may be used. [12] In addition, different types of warts as well as those in various parts of patients’ body may need different treatments.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of intralesional injection of mumps-measles-rubella vaccine in patients with wart

2014

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Background:In the previous studies, it has been shown that mumps-measles-rubella (MMR) vaccine resulted in regression of warts via immunomodulatory effect and induction of immune system. Due to the high prevalence of warts in various populations, we evaluated the efficacy of MMR vaccine injection in the treatment of cutaneous warts.Materials and Methods:This double-blind randomized controlled clinical trial was conducted in Hazrat-e-Rasoul Hospital in Tehran in 2011-2012 on 24 patients with warts who were allocated to two groups including MMR group and normal saline group. MMR vaccine was injected intralesionally in the MMR group, whereas normal saline was injected into the lesions in the second group. These injections were repeated every 2 weeks intervals for maximum 3 injections. All patients were followed up every 15-day interval up to 45 days and then up to 6 months regarding relapses and finally, side effects, probable relapse, and therapeutic outcomes were evaluated and compared.Results:At the end of follow-up period, therapeutic outcomes in the MMR group included no cure in 2 cases, relative cure in 4 cases, and complete cure in 18 cases. In normal saline group, these rates included no cure in seven cases, relative cure in nine cases, and complete cure in six cases (P < 0.001). No significant complication occurred in the two groups.Conclusion:MMR vaccine may result in desirable therapeutic response. The hypothesis that is considered here is that MMR vaccine, via induction of cellular and humoral immune system, accelerates the destruction of virus and infected host cells.

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“…13,14,15 This is due to its ability to dissolve keratin and penetrate deeply the skin. 13,14,15 Furthermore, treatment is generally well tolerated and does not entail systemic side effects. Nonetheless, there are no comparative studies on the use of KOH for the treatment of GW.…”

Section: Introductionmentioning

confidence: 99%

A prospective, open, comparative study of 5% potassium hydroxide solution versus cryotherapy in the treatment of genital warts in men

Camargo

Belda

Fagundes

et al. 2014

An. Bras. Dermatol.

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BACKGROUNDGenital warts are caused by human papillomavirus infection and represent one of the most common sexually transmitted diseases. Many infections are transient but the virus may recur, persist, or become latent. To date, there is no effective antiviral treatment to eliminate HPV infection and most therapies are aimed at the destruction of visible lesions. Potassium hydroxide is a strong alkali that has been shown to be safe and effective for the treatment of genital warts and molluscum contagiosum. Cryotherapy is considered one of the most established treatments for genital warts. No comparative trials have been reported to date on the use of potassium hydroxide for genital warts.OBJECTIVEA prospective, open-label, randomized clinical trial was conducted to compare topical potassium hydroxide versus cryotherapy in the treatment of genital warts affecting immunocompetent, sexually active men.METHODSOver a period of 10 months, 48 patients were enrolled. They were randomly divided into two groups and selected on an alternative basis for either potassium hydroxide therapy or cryotherapy. While response to therapy did not differ substantially between both treatment modalities, side effects such as local pain and post-treatment hypopigmentation were considerably more prevalent in the groups treated using cryotherapy.RESULTIn our study, potassium hydroxide therapy proved to be at least as effective as cryotherapy and offered the benefit of a better safety profile.CONCLUSIONTopical 5% potassium hydroxide presents an effective, safe, and low-cost treatment modality for genital warts in men and should be included in the spectrum of therapies for genital warts.

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Treatment of genital warts in men with potassium hydroxide

Cited by 10 publications

References 3 publications

A comparison of a 5% potassium hydroxide solution with a 5‐fluorouracil and salicylic acid combination in the treatment of patients with anogenital warts: a randomized, open‐label clinical trial

A comparison of a 5% potassium hydroxide solution with a 5‐fluorouracil and salicylic acid combination in the treatment of patients with anogenital warts: a randomized, open‐label clinical trial

Efficacy of intralesional injection of mumps-measles-rubella vaccine in patients with wart

A prospective, open, comparative study of 5% potassium hydroxide solution versus cryotherapy in the treatment of genital warts in men

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