Treatment of genitourinary syndrome of menopause: the potential effects of intravaginal ultralow-concentration oestriol and intravaginal dehydroepiandrosterone on quality of life and sexual function

Rosa, Valentina Lucia La; Ciebiera, Michał; Lin, Lie Chwen; Fan, Shang­rong; Butticè, Salvatore; Sathyapalan, Thozhukat; Jędra, Robert; Lordêlo, Patrícia; Favilli, Alessandro

doi:10.5114/pm.2019.86836

Cited by 6 publications

(6 citation statements)

References 96 publications

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“…La dehidroepiandrosterona (DHEA), un esteroide sexual, ha mostrado resultados prometedores en la reducción de los síntomas de urgencia y la incontinencia urinaria en mujeres posmenopáusicas con VH y sindromes genitourinarios (17).…”

Section: Medicamentos Comunes Utilizadosunclassified

Incontinencia Urinaria en La Mujer: Enfoque Terapeutico Actual

Montoya,

León,

Zamora

et al. 2024

Braz. J. Implantol. Health Sci.

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La incontinencia urinaria en la mujer es una condición clínica en la cual se produce una pérdida involuntaria de orina, lo que puede resultar en un impacto significativo en la calidad de vida de las pacientes Objetivo: Analizar los enfoques terapéuticos actuales para la incontinencia urinaria en la mujer, con el fin de proporcionar una visión integral de las estrategias más efectivas y actualizadas disponibles en la actualidad. Metodología: Se realizaron búsquedas exhaustivas en bases de datos especializadas utilizando términos de búsqueda específicos. Se incluyeron estudios originales y revisiones relevantes que abordaran enfoques terapéuticos actuales para la incontinencia urinaria en mujeres adultas, con limitaciones temporales a publicaciones de los últimos 10 años y en idioma inglés o español. Resultados: Se identificaron varios enfoques terapéuticos actuales para la incontinencia urinaria en la mujer, incluyendo enfoques farmacológicos, no farmacológicos y quirúrgicos. Los enfoques farmacológicos incluyen el uso de anticolinérgicos, mirabegron y otros medicamentos, mientras que los enfoques no farmacológicos incluyen la terapia conductual y los ejercicios del suelo pélvico. Los enfoques quirúrgicos incluyen procedimientos como la colocación de cintas suburetrales y la neuromodulación sacra. Conclusiones: La incontinencia urinaria en la mujer es una condición clínica que puede tener un impacto significativo en la calidad de vida de las pacientes. Existen diversos enfoques terapéuticos disponibles, que van desde opciones farmacológicas hasta intervenciones no farmacológicas y quirúrgicas. Las nuevas tecnologías y terapias innovadoras representan avances prometedores en el tratamiento de esta condición, ofreciendo nuevas alternativas para pacientes con incontinencia urinaria refractaria o que no responden a las opciones de tratamiento convencionales.

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Section: Medicamentos Comunes Utilizadosunclassified

Incontinencia Urinaria en La Mujer: Enfoque Terapeutico Actual

Montoya,

León,

Zamora

et al. 2024

Braz. J. Implantol. Health Sci.

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“…DHEA is metabolized to estrogens in vaginal mucosal cells and improves symptoms of vaginal irritation. 28 Studies showed that DHEA administered intravaginally for 12 weeks improves vaginal cytological environment, lowers vaginal pH, and promotes cell maturation, resulting in symptom relief. Vaginal DHEA affects serum androgen and estradiol concentrations, which increase as a result, making the safety of DHEA use in hormone-dependent cancers an issue.…”

Section: Treatment Approachmentioning

confidence: 99%

Modern approach to the management of genitourinary syndrome in women with gynecological malignancies

Kovačević

Cilenšek

Merlo

et al. 2023

Radiology and Oncology

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Background The term genitourinary syndrome of menopause was first used in 2014 by the North American Menopause Society and the International Society for the Study of Women's Sexual Health to describe conditions previously known as atrophic vaginitis, urogenital atrophy, or vulvovaginal atrophy. It is a complex, chronic, progressive condition characterized by a wide range of signs and symptoms affecting sexual function and the tissues of the urinary and genital tracts. The main cause of genitourinary syndrome of menopause is estrogen deficiency caused by ovarian removal or dysfunction. The most bothersome symptoms are vaginal dryness, decreased vaginal lubrication, and pain during penetration and intercourse. They all have a negative impact on the quality of life. Conclusions The main goal of treatment is to relieve the symptoms. Treatment modalities are pharmacological or non-pharmacological. The first-line treatment for mild to moderate symptoms is the use of personal lubricants and moisturizers, but the gold standard is estrogen replacement therapy. Hormone therapy may not be an option for women with hormone-dependent cancer.

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“…According to other authors, although oral and local estrogen therapy does not improve SUI per se, it is able to improve subjective symptoms in some cases [89,90]; in these patients, a behavioral approach such as perineal pelvic rehabilitation and reinforcement of periurethral muscles can be considered the treatment of choice [91,92].…”

Section: Urinary Incontinencementioning

confidence: 99%

Multidisciplinary management of women with pelvic organ prolapse, urinary incontinence and lower urinary tract symptoms. A clinical and psychological overview

Rosa

Ciebiera

Lin

et al. 2019

Self Cite

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Although female sexual dysfunctions are common among women with urogynecological conditions, they have not been thoroughly studied and there are still many questions without an answer. The recent evidence on sexual disorders in women with urogynecological diseases shows a quite wide spectrum of therapeutic approaches, which require the physicians to take into account not only the primary symptoms, but also all the associated factors negatively affected. It has been widely underlined that gynecological diseases are often associated with high stress and have a negative impact on quality of life and psychological well-being of women affected. For this reason, a multidisciplinary approach for the management of these diseases is highly recommended. Also in the case of urogynecological disorders, it is important to take into account psychological outcomes throughout the diagnostic and therapeutic process. In the light of these considerations, the aim of this short review is to evaluate the impact of the main urogynecological diseases and the currently available therapeutic options in order to improve quality of life and sexuality of these patients and to stress the need for a multidisciplinary approach in order to minimize the negative consequences of these diseases for the sexual well-being of women and their partners.

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Treatment of genitourinary syndrome of menopause: the potential effects of intravaginal ultralow-concentration oestriol and intravaginal dehydroepiandrosterone on quality of life and sexual function

Cited by 6 publications

References 96 publications

Incontinencia Urinaria en La Mujer: Enfoque Terapeutico Actual

Incontinencia Urinaria en La Mujer: Enfoque Terapeutico Actual

Modern approach to the management of genitourinary syndrome in women with gynecological malignancies

Multidisciplinary management of women with pelvic organ prolapse, urinary incontinence and lower urinary tract symptoms. A clinical and psychological overview

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