“…4,6,7 Management of mucosal fenestration defects usually require a combined therapy (endodontic treatment and periodontal surgeries) to achieve predictable treatment outcomes. Reported treatments include endodontic therapy with root-end resection 2,4,8,9 root surface debridement with chlorhexidine mouth-rinsing 9,10 excisions of the epithelial margin with primary closure of the mucosal defect 2,4,11 pedicle flap surgery 8,9 autologous soft tissue graft 5,7,12 or substitute 13,14 and/or regenerative osseous surgery. 1,6,7 Although in past few years, use of autologous platelet concentrates such as platelet rich fibrin (PRF) alone in bone regeneration 15 and minimally invasive surgical techniques has gained wide acceptance and popularity among clinicians in reconstructive surgery, their application in management of mucosal fenestration has never been reported.…”