Treatment of Gonorrhea with Spectinomycin Hydrochloride: Comparison with Standard Penicillin Schedules

Wc, Duncan; Wr, Holder; Dp, Roberts; Jm, Knox

doi:10.1128/aac.1.3.210

Cited by 28 publications

(10 citation statements)

References 8 publications

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“…for 4 g. spectinomycin hydrochloride. Duncan, Holder, Roberts, and Knox (1972) compared the effect of spectinomycin hydrochloride with that of penicillin. Cure rates were over 90 per cent.…”

Section: Cultures From Different Sites In Femalesmentioning

confidence: 99%

Spectinomycin hydrochloride (Trobicin) in the treatment of gonorrhoea. Observation of resistant strains of Neisseria gonorrhoeae.

Reyn¹,

Schmidt²,

Trier³

et al. 1973

Sexually Transmitted Infections

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Section: Cultures From Different Sites In Femalesmentioning

confidence: 99%

Spectinomycin hydrochloride (Trobicin) in the treatment of gonorrhoea. Observation of resistant strains of Neisseria gonorrhoeae.

Reyn¹,

Schmidt²,

Trier³

et al. 1973

Sexually Transmitted Infections

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“…Concentrations of antibiotic exhibiting bactericidal activity exceeded the inhibitory concentration by at least fourfold. Regression graphs were plotted for results obtained with 30-, 100-, 200-, and 300-pg spectinomycin discs; tentative interpretative standards are proposed.Spectinomycin hydrochloride, a basic antibiotic prepared from Streptomyces spectabilis, has been found to be highly effective in the therapy of gonorrhea (2,3,5). Because, with the usually recommended dosages, peak concentrations of this agent in the blood may be about 100 jig/ml (9,11) and urinary concentrations may attain 1,000 ,g/ml, this investigation was undertaken to study the activity of spectinomycin against bacteria other than Neisseria gonorrhoeae.…”

mentioning

confidence: 99%

“…Spectinomycin hydrochloride, a basic antibiotic prepared from Streptomyces spectabilis, has been found to be highly effective in the therapy of gonorrhea (2,3,5). Because, with the usually recommended dosages, peak concentrations of this agent in the blood may be about 100 jig/ml (9,11) and urinary concentrations may attain 1,000 ,g/ml, this investigation was undertaken to study the activity of spectinomycin against bacteria other than Neisseria gonorrhoeae.…”

mentioning

confidence: 99%

In Vitro Antibacterial Activity of Spectinomycin

Washington

1972

Antimicrob Agents Chemother

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The in vitro inhibitory and bactericidal activities of spectinomycin hydrochloride were tested against a variety of bacteria. The antibiotic was inhibitory at 31.2 ,g/ml to most strains of Escherichia coli, Klebsiella, Enterobacter, and Staphylococcus epidermidis. Concentrations of antibiotic exhibiting bactericidal activity exceeded the inhibitory concentration by at least fourfold. Regression graphs were plotted for results obtained with 30-, 100-, 200-, and 300-pg spectinomycin discs; tentative interpretative standards are proposed.Spectinomycin hydrochloride, a basic antibiotic prepared from Streptomyces spectabilis, has been found to be highly effective in the therapy of gonorrhea (2,3,5). Because, with the usually recommended dosages, peak concentrations of this agent in the blood may be about 100 jig/ml (9,11) and urinary concentrations may attain 1,000 ,g/ml, this investigation was undertaken to study the activity of spectinomycin against bacteria other than Neisseria gonorrhoeae. MATERLALS AND METHODSSpectinomycin (Trobicin) was supplied as a sterile dry powder in 100-mg vials through the courtesy of R. T. Pfeifer (The Upjohn Co., Kalamazoo, Mich.).The antibiotic was dissolved in sterile distilled water.Minimal inhibitory concentrations (MIC) were determined in Mueller-Hinton agar (MHA) and Trypticase soy agar (TSA), both obtained from BBL, by the agar dilution technique (12). The inoculareplicating device described by Steers and co-workers (10) was used, and the concentrations of spectinomycin tested were 1,000, 500, 250, 125, 62.5, 31.2, 15.6, and 7.8 C, 0.5 ml of the broth in each tube exhibiting no visible turbidity was pipetted into correspondingly labeled tubes containing 15 ml of molten (50 C) brain-heart infusion agar, and pour plates were prepared. The pour plates were incubated at 35 C for 72 hr, and the concentrations of spectinomycin that resulted in 99.9% kill of the initial inoculum were calculated.Disc diffusion tests were performed according to the method described by Bauer et al. (1)

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“…Several well-controlled studies have found spectinomycin hydrochloride to be useful in the treatment of uncomplicated gonorrhea (3,5,8). This study confirms the utility of spectinomycin hydrochloride in the treatment of uncomplicated gonococcal infections.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Spectinomycin Hydrochloride and Aqueous Procaine Penicillin G in the Treatment of Uncomplicated Gonorrhea

Duancic

Fiumara

Alpert

et al. 1974

Antimicrob Agents Chemother

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Men and women with uncomplicated gonorrhea were randomly assigned to receive aqueous procaine penicillin G (2,400,000 U for men; 2,400,000 U daily for 2 days for women) or spectinomycin hydrochloride (2.0 g for men; 4.0 g for women). Among men who returned for post-treatment evaluation within 10 days, treatment failures were noted among 16 (20.3%) of 79 men who received penicillin and 8 (9.5%) of 84 men who received spectinomycin (P < 0.1). Similarly, 6 (13.3%) of 45 women who received penicillin and 3 (6.5%) of 46 women who received spectinomycin had positive endocervical cultures for Neisseria gonorrhoeae at the time of the post-treatment examination (P = not significant).

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Treatment of Gonorrhea with Spectinomycin Hydrochloride: Comparison with Standard Penicillin Schedules

Cited by 28 publications

References 8 publications

Spectinomycin hydrochloride (Trobicin) in the treatment of gonorrhoea. Observation of resistant strains of Neisseria gonorrhoeae.

Spectinomycin hydrochloride (Trobicin) in the treatment of gonorrhoea. Observation of resistant strains of Neisseria gonorrhoeae.

In Vitro Antibacterial Activity of Spectinomycin

Comparison of Spectinomycin Hydrochloride and Aqueous Procaine Penicillin G in the Treatment of Uncomplicated Gonorrhea

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