Treatment of growth plate injury with microencapsulated chondrocytes

Li, Wenchao; Xu, Ruijiang; Xue, Yuan; Huang, Jiayi; Gao, Yuhong

doi:10.1007/s12257-012-0451-1

Cited by 5 publications

(6 citation statements)

References 23 publications

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“…In addition, they observed similar effects when the chondrocytes were either implanted immediately after the growth plate injury, or implanted following surgical removal of an existing bone bridge formed following a growth plate injury induced earlier (Lee et al 1998). More recently, Jin et al (2006) and Li et al (2013) also in a rabbit growth plate injury model reported success in restoring the growth plate to its original form, preventing bone bridge formation and in possibly preventing early ossification and closure of the growth plate following transplantation of chondrocytes (Jin et al 2006) or chondrocytes that were microencapsulated ) using a semipermeable membrane shown to be able to reduce potential transplantationassociated immunological reactions (Koo et al 2008, Revell & Athanasiou 2009.…”

Section: Chondrocyte Transplantation and The Regeneration Of Injured mentioning

confidence: 99%

RECENT RESEARCH ON THE GROWTH PLATE: Mechanisms for growth plate injury repair and potential cell-based therapies for regeneration

Chung

Chen

2014

Journal of Molecular Endocrinology

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Injuries to the growth plate cartilage often lead to bony repair, resulting in bone growth defects such as limb length discrepancy and angulation deformity in children. Currently utilised corrective surgeries are highly invasive and limited in their effectiveness, and there are no known biological therapies to induce cartilage regeneration and prevent the undesirable bony repair. In the last 2 decades, studies have investigated the cellular and molecular events that lead to bony repair at the injured growth plate including the identification of the four phases of injury repair responses (inflammatory, fibrogenic, osteogenic and remodelling), the important role of inflammatory cytokine tumour necrosis factor alpha in regulating downstream repair responses, the role of chemotactic and mitogenic platelet-derived growth factor in the fibrogenic response, the involvement and roles of bone morphogenic protein and Wnt/B-catenin signalling pathways, as well as vascular endothelial growth factor-based angiogenesis during the osteogenic response. These new findings could potentially lead to identification of new targets for developing a future biological therapy. In addition, recent advances in cartilage tissue engineering highlight the promising potential for utilising multipotent mesenchymal stem cells (MSCs) for inducing regeneration of injured growth plate cartilage. This review aims to summarise current understanding of the mechanisms for growth plate injury repair and discuss some progress, potential and challenges of MSC-based therapies to induce growth plate cartilage regeneration in combination with chemotactic and chondrogenic growth factors and supporting scaffolds.

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Section: Chondrocyte Transplantation and The Regeneration Of Injured mentioning

confidence: 99%

RECENT RESEARCH ON THE GROWTH PLATE: Mechanisms for growth plate injury repair and potential cell-based therapies for regeneration

Chung

Chen

2014

Journal of Molecular Endocrinology

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“…From this standpoint, allogeneic chondrocytes may represent a better alternative if they present good results in future studies. Li et al (2013) used allogeneic chondrocytes harvested from distal femoral GPs, microencapsulated by semipermeable membranes, and transplant the preparations in a GP injury model. Sixteen weeks later, the chondrocytes-treated group showed less length discrepancy and angular deformity than other groups, the histological results also exhibited columnar arrangement formed by neogenetic chondrocytes at the injured site, which indicated that the allogeneic chondrocytes could prevent bone formation to the same extent as autologous chondrocytes.…”

Section: Cartilage Tissue Engineering For Gp Injuriesmentioning

confidence: 99%

“…In a GP injuries model, alginate-polylysinealginate semipermeable membranes were used for chondrocyte encapsulation. After 16 weeks of implantation into defects, the radiological results showed less angular deformity and length discrepancies, indicating this alginate material was suitable for GP reconstruction ( Li et al, 2013 ). However, alginate hydrogel is negatively charged, which results in a dissimilar environment for encapsulated cells ( Freeman and Kelly, 2017 ).…”

Section: Cartilage Tissue Engineering For Gp Injuriesmentioning

confidence: 99%

Enlightenment of Growth Plate Regeneration Based on Cartilage Repair Theory: A Review

Wang

et al. 2021

Front. Bioeng. Biotechnol.

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The growth plate (GP) is a cartilaginous region situated between the epiphysis and metaphysis at the end of the immature long bone, which is susceptible to mechanical damage because of its vulnerable structure. Due to the limited regeneration ability of the GP, current clinical treatment strategies (e.g., bone bridge resection and fat engraftment) always result in bone bridge formation, which will cause length discrepancy and angular deformity, thus making satisfactory outcomes difficult to achieve. The introduction of cartilage repair theory and cartilage tissue engineering technology may encourage novel therapeutic approaches for GP repair using tissue engineered GPs, including biocompatible scaffolds incorporated with appropriate seed cells and growth factors. In this review, we summarize the physiological structure of GPs, the pathological process, and repair phases of GP injuries, placing greater emphasis on advanced tissue engineering strategies for GP repair. Furthermore, we also propose that three-dimensional printing technology will play a significant role in this field in the future given its advantage of bionic replication of complex structures. We predict that tissue engineering strategies will offer a significant alternative to the management of GP injuries.

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“…Microencapsulated somatic cells can be used to treat neurological and endocrine diseases, such as diabetes, syndromes after the removal of ovaries, and Parkinson's disease . Microencapsulated stem cells can aid bone regeneration and growth plate injury, repair the myocardium and improve angiogenesis . Microencapsulated recombinant cells can be used to enhance memory in Alzheimer's disease and increase IDUA activity in mucopolysaccharidosis type I .…”

Section: Introductionmentioning

confidence: 99%

The relationship between the inflammatory response and cell adhesion on alginate-chitosan-alginate microcapsules after transplantation

Shen

Zhang

Chen

et al. 2014

J. Biomed. Mater. Res.

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Cell microencapsulation technology is a potential alternative therapy, but cell overgrowth and adhesion on the microcapsules after transplantation shortens their time of therapeutic efficacy. Inflammatory cells were the main cells that adhered to the microcapsules, so understanding the body's inflammatory processes would help to better identify the mechanisms of cell adhesion to the outer surface of the microcapsules. Our study measured the inflammatory cells and the cytokines and characterized the associated changes in the alginate-chitosan-alginate (ACA) microcapsules 1, 7, 14, and 28 days after implantation in the peritoneal cavity. Then the relationship between the inflammatory response and cell adhesion on the microcapsules was evaluated by multiple regression analysis. The results showed that the microcapsules did not evoke a systemic inflammatory response, but initiated a local inflammatory response in the peritoneal cavity. Furthermore, the correlation analysis showed that the level of cell adhesion on the microcapsules was related to the number of lymphocytes and macrophages, and the amount of IL-6, IL-10, and MCP-1 in the peritoneal cavity. Our results may provide a foundation for reducing the immune response to these microcapsules, prolonging graft survival and improving the efficacy of these treatments.

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Treatment of growth plate injury with microencapsulated chondrocytes

Cited by 5 publications

References 23 publications

RECENT RESEARCH ON THE GROWTH PLATE: Mechanisms for growth plate injury repair and potential cell-based therapies for regeneration

RECENT RESEARCH ON THE GROWTH PLATE: Mechanisms for growth plate injury repair and potential cell-based therapies for regeneration

Enlightenment of Growth Plate Regeneration Based on Cartilage Repair Theory: A Review

The relationship between the inflammatory response and cell adhesion on alginate-chitosan-alginate microcapsules after transplantation

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