Treatment of Harvest Mite Infestation in Dogs Using a Permethrin 54.5% and Fipronil 6.1% (Effitix®) Topical Spot-On Formulation

Abstract

Background—The study aims to assess the efficacy of a permethrin 54.5%-fipronil 6.1%-based spot-on solution in dogs naturally infested with Neotrombicula in an open-label controlled study. Methods—Ten naturally infested dogs received one drop per affected site on day (D) 0, and on D14, the rest of the pipette was applied on the skin between the shoulders. Five dogs served as sentinels. Parasite score (0–3), skin lesions (0–4), and investigator pruritus scale (0–4) were assessed on D0, D1, D14, and D28. Results—No treated dogs developed adverse reactions. Parasite score of sentinel dogs was maintained between 1.8 (D0, D1, and D28) and 2.2 (D14). In treated dogs, D0 parasite score was 2.4. It was significantly reduced from D1 (0.5; p < 0.002) to D28 (0.1; p < 0.002). The lesion score was 2.9 on D0 and D1; it was significantly reduced on D14 (0.6; p < 0.002) and D28 (0.1; p < 0.002). Similarly, investigator pruritus scale (D0, 2.2) scores significantly decreased on D14 (0.4; p < 0.004) and D28 (0.2; p < 0.002). Conclusions—The combination permethrin-fipronil appears to be well-tolerated, rapidly and durably effective in the control of localized canine harvest mite infestation.

The threat of veterinary medicinal products and biocides on pollinators: A One Health perspective

“…[ 63 ], and, therefore these products are authorized as Biocides. Besides, permethrin and deltamethrin asVMPs are directly administrable on cattle and small animals as a pour-on insecticide as flea and tick control agents [ 63 , 64 ].…”

A new case of trombiculiasis caused by Eutrombicula daemoni Bassini-Silva & Jacinavicius, 2018 (Trombidiformes: Trombiculidae) in a dog from Brazil

“…Despite the number of chiggers in the world, Zhang et al ( 2011) estimated the existence of approximately 3,700 chiggers species. However, trombiculiasis in dogs have been reported in several places, as in Europe (Fain & Net 2000;Giannoulopoulos 2012;Stekolnikov et al 2016;Lecru 2019;Apesteguía et al 2019), Asia (Chung et al 2015;Kaufman et al 2015), Africa (Vercammen-Grandjean & Brennan 1957; Heyne et al 2001), Oceania (McCulloch 1946, and America (Floch & Abonnenc 1941;Michener 1946;Jenkins 1949;Brennan & Yunker 1964;Sampaio et al 2020), still few records when compared to the diversity of this family. In the present study, we provide the second record of trombiculiasis on a dog from Brazil.…”