2004
DOI: 10.1111/j.1468-3083.2004.00963.x
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Treatment of head and neck dermatitis comparing itraconazole 200 mg and 400 mg daily for 1 week with placebo

Abstract: One week of treatment with 200 or 400 mg itraconazole as a single treatment has a significant effect on the head and neck area. Compared to placebo there was a significant improvement in SCORAD of the head and neck area in favour of the 200 mg itraconazole group after 14 days. The important observation seems to be that antifungal systemic treatment has a significant SCORAD reduction of atopic dermatitis, irrespective of the presence of allergy.

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Cited by 79 publications
(66 citation statements)
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“…However, the optimal administration regimen has not yet been standardized, and 100, 200, or even 400 mg per day for 1 or 2 weeks have been administered (6,7,10). Our preliminary study demonstrated that 100 mg of itraconazole for 4 weeks reduced cutaneous Malassezia colonization by approximately 90% in patients with atopic dermatitis (unpublished data).…”
mentioning
confidence: 87%
“…However, the optimal administration regimen has not yet been standardized, and 100, 200, or even 400 mg per day for 1 or 2 weeks have been administered (6,7,10). Our preliminary study demonstrated that 100 mg of itraconazole for 4 weeks reduced cutaneous Malassezia colonization by approximately 90% in patients with atopic dermatitis (unpublished data).…”
mentioning
confidence: 87%
“…A number of studies have also been conducted with itraconazole. In one study, 53 HANAD patients were divided into three groups that received 200 mg itraconazole, 400 mg itraconazole, or placebo daily (Svejgaard et al 2004). The study included a 7-day treatment period and a follow-up period of 105 days.…”
Section: Susceptibility Of Malassezia To Drug Treatmentmentioning
confidence: 99%
“…and Malassezia spp. has been implicated as an exacerbating or intractable factor in the symptoms of AD (Savolainen et al, 1993;Tanaka et al, 1994;Kitamura et al, 1997;Morita et al, 1999;Linder et al, 2000;Faergemann 2002;Kanda et al, 2002;Svejgaard et al, 2004). Candida spp.…”
Section: Antigen-specific Inflammation Caused Via Activation Of Antigmentioning
confidence: 99%
“…Of the 20 patients, 18 completed the ketoconazole treatment regimen for 5 months and most patients showed a good to moderate response for ketoconazole 200 mg daily during the 2 months but no further improvement after the administration of ketoconazole 200 mg twice a week for another 3 months. Svejgaard et al (2004) evaluated the efficacy of oral itraconazole in the treatment of AD patients with head and neck dermatitis in a randomized, double-blind, placebo-controlled study. The AD patients were treated daily with itraconazole 200 mg, 400 mg or placebo for 7 days.…”
Section: Control Of Fungi In Ad Patientsmentioning
confidence: 99%
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