Treatment of head and neck cancer with intra-arterial cytotoxic drugs and radiotherapy

Sealy, R.; Helman, P

doi:10.1002/1097-0142(197207)30:1<187::aid-cncr2820300126>3.0.co;2-0

Cited by 37 publications

(8 citation statements)

References 4 publications

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“…It is obvious that in advanced cancers many factors are responsible for the poor response seen, such as compromised performance status, poor nutrition, and the large mass of tumour (Bertino et al, 1973). Moreover, in patients treated earlier by surgery and radiotherapy the regional blood supply to the tumour bed is disturbed (Sealy and Helman, 1972). This is clearly demonstrated in our study in the 30 patients in 0-0 category, who were treated for recurrence of disease following radiotherapy.…”

Section: Discussionsupporting

confidence: 54%

Experiences with intra‐arterial chemotherapy for head and neck cancer

Jussawalla

Shetty

1978

Journal of Surgical Oncology

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During the 10-year period from 1966-1975, 250 patients with various head and neck cancers were treated by intra-arterial chemotherapy using single agents or various combinations. Only 15 patients showed response of I-C category according to Karnofsky's criteria, and 100 patients had I-B response. Another 100 patients showed I-A category of response and 35 patient had progressive disease out of which 5 patients exhibited excessive toxicity to drugs, eventually succumbing to it. A majority of patients in nonresponding (O-O) category and I-A category were earlier treated by radiotherapy, and intra-arterial chemotherapy was given for recurrent disease. The responses were relatively good whenever chemotherapy was given as a primary treatment before surgery and radiotherapy. Again response was additive when chemotherapy was given concurrently with radiotherapy.

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Section: Discussionsupporting

confidence: 54%

Experiences with intra‐arterial chemotherapy for head and neck cancer

Jussawalla

Shetty

1978

Journal of Surgical Oncology

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“…There seems to be n o difference between the 1-year clearance rate in this group treated in oxygen and those previously reported treated in air. 7 T h e complications are shown in Table 2. T h e one death was of a frail elderly man with gross carcinoma of the pharynx.…”

Section: Resultsmentioning

confidence: 99%

The treatment of locally advanced cancer of the head and neck with intra-arterial cytotoxics, cobalt, and hyperbaric oxygen therapy

Sealy

Helman

Greenstein

1974

Cancer

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“…CONCLUSIONS From the several reports now available from rather scattered individual centres, it seems clear that the use of appropriate combinations of chemotherapeutic agents infused into a suitable regional artery of supply can be most effective as basal treatment. A previously incurable lesion may thus be reduced to proportions and reduced in viability to such an extent that management with follow-up radiotherapy and/or surgery can have some prospect of tumour eradication (Jussawalla and Shetty, 1978;Koyama et a h , 1975;Sealy and Helman, 1972;Stephens, 1978). the numbers of patients appropriate to meet these criteria in any one centre are inevitably quite limited.…”

Section: Discussionmentioning

confidence: 99%

The Intraarterial Infusion of Chemotherapeutic Agents as “Basal” Treatment of Cancer: Evidence of Increased Drug Activity in Regionally Infused Tissues

Stephens

Harker

Crea

1980

Australian and New Zealand Journal of Surgery

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There is evidence from a number of centres that some forms of locally advanced and aggressive cancers which are difficult to eradicate by standard means can be reduced by the use 01 “basal” chemotherapy to a degree which will allow more certain tumour eradication by subsequent radiotherapy and/or surgery. Clinicians have been divided as to whether there is an advantage in giving the chemotherapeutic agents directly into a regional artery of supply where this is feasible, as opposed to their systemic administration. This paper documents supportive evidence that some and possibly many chemotherapeutic agents are more effective if given regionally into an artery of supply. There is a higher incidence of local side‐effects in the region infused, including loss of hair, inflammatory changes, and ulceration of the skin or mucosa of the region infused. After intraarterial infusion of tagged bleomycin (indium‐Ill bleomycin) into a limb, the radioactive isotope remained more concentrated in the limb infused than in the opposite limb for at least 24 hours. Systemic side‐effects, including bone‐marrow depression, are less frequent and less severe in patients given chemotherapeutic agents by intraarterial infusion than if the same doses of agents are given intravenously. There is now sufficient evidence of the value of basal chemotherapy used in this way to make it mandatory that medical oncologists and surgeons, working together, should plan controlled studies to determine the most appropriate applications of this technique of management.

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Treatment of head and neck cancer with intra-arterial cytotoxic drugs and radiotherapy

Cited by 37 publications

References 4 publications

Experiences with intra‐arterial chemotherapy for head and neck cancer

Experiences with intra‐arterial chemotherapy for head and neck cancer

The treatment of locally advanced cancer of the head and neck with intra-arterial cytotoxics, cobalt, and hyperbaric oxygen therapy

The Intraarterial Infusion of Chemotherapeutic Agents as “Basal” Treatment of Cancer: Evidence of Increased Drug Activity in Regionally Infused Tissues

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