Treatment of health-care-associated infections caused by Gram-negative bacteria: a consensus statement

Chopra, Ian; Schofield, Christopher J.; Everett, Martin; O’Neill, Alex J.; Miller, Keith; Wilcox, Mark H.; Frère, Jean‐Marie; Dawson, Mike; Czaplewski, Lloyd G.; Urleb, U.; Courvalin, Patrice

doi:10.1016/s1473-3099(08)70018-5

Cited by 207 publications

(159 citation statements)

References 59 publications

Supporting

Mentioning

157

Contrasting

Unclassified

Order By: Relevance

“…13 Our investigation carried out to measure the resistance of the isolated bacteria to several antibiotics confirmed the high resistance of Acinetobacter spp. to CRO, CN, AK, MRP, ATM and TZP.…”

Section: Discussionsupporting

confidence: 60%

“…11,12 In this respect, updated data from the U.S. National Healthcare Safety Network indicated that Gram-negative microorganisms (P. aeruginosa, and A. baumannii) predominate in the cases of nosocomial pneumonia. 13 Taking into consideration this universal relevant clinical problem, we made a characterization of infection of the lower respiratory tract of 741 ventilated patients admitted to the ICUs with presumed nosocomial pneumonia. From these patients 1254 samples were collected and assessed by several microbiology tests.…”

Section: Morganella Morgani Proteus Mirabilis Proteus Penneri Proteusmentioning

confidence: 99%

See 1 more Smart Citation

Characterization and sensitivity to antibiotics of bacteria isolated from the lower respiratory tract of ventilated patients hospitalized in intensive care units

Medell¹,

Medell²,

Martínez³

et al. 2012

Braz J Infect Dis

View full text Add to dashboard Cite

Objective: This observational study described the characterization of bacteria isolated from the lower respiratory tract of ventilated patients hospitalized in intensive care units.The demonstration of isolated microorganism resistance to antibiotics and a time-trend analysis of infection comparing a 48-month period were also other objectives.Method: Semi-quantitative assays of 1254 samples taken from 741 ventilated patients were performed, while pathogens were identified using the Enterotube II assay and VITEK 2 Compact equipment. Bacterial resistance to antibiotics was assessed by the Kirby-Bauer disc diffusion method and time-trend analysis of infection was based on data recorded by hospital microbiology laboratories.

show abstract

Section: Discussionsupporting

confidence: 60%

Section: Morganella Morgani Proteus Mirabilis Proteus Penneri Proteusmentioning

confidence: 99%

Characterization and sensitivity to antibiotics of bacteria isolated from the lower respiratory tract of ventilated patients hospitalized in intensive care units

Medell¹,

Medell²,

Martínez³

et al. 2012

Braz J Infect Dis

View full text Add to dashboard Cite

show abstract

“…In summary, the most frequently UTI pathogens could be arranged in the decreasing order, Klebsiella, E. coli, Pseudomonas and Enterobacter; not surprisingly the fungus Candida sp. was also the most common pathogen [25,26] .…”

Section: Discussionmentioning

confidence: 99%

Surveillance of multidrug resistant uropathogenic bacteria in hospitalized patients in Indian

Mishra

Debata

Padhy

2013

Asian Pacific Journal of Tropical Biomedicine

View full text Add to dashboard Cite

Objective: To record surveillance, antibiotic resistance of uropathogens of hospitalized patients over a period of 18 months. Methods: Urine samples from wards and cabins were used for isolating urinary tract infection (UTI)-causing bacteria that were cultured on suitable selective media and identified by biochemical tests; and their antibiograms were ascertained by KirbyBauer's disc diffusion method, in each 6-month interval of the study period, using 18 antibiotics of five different classes. Results: From wards and cabins, 1 245 samples were collected, from which 996 strains of bacteria belonging to 11 species were isolated, during April 2011 to September 2012. Two Gram-positive, Staphylococcus aureus (S. aureus) and Enterococcus faecalis (E. faecalis), and nine Gram-negative bacteria, Acinetobacter baumannii, Citrobacter sp., Escherichia coli, Enterobacter aerogenes, Klebsiella pneumoniae, Klebsiella oxytoca, Proteus mirabilis, Proteus vulgaris and Pseudomonas aeruginosa were isolated. Both S. aureus and E. faecalis were vancomycin resistant, and resistant-strains of all pathogens increased in each 6-month period of study. Particularly, all Gram-negatives were resistant to nitrofurantoin and co-trimoxazole, the most preferred antibiotics of empiric therapy for UTI. Conclusions: Antibiograms of 11 UTIcausing bacteria recorded in this study indicated moderately higher numbers of strains resistant to each antibiotic studied, generating the fear of precipitating fervent episodes in public health particularly with bacteria, Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae and S. aureus. Moreover, vancomycin resistance in strains of S. aureus and E. faecalis is a matter of concern.

show abstract

“…The widespread emergence of bacterial resistance to existing antibiotics is a global health threat and has emphasized the need to develop new antibacterial agents directed toward novel targets [1]. Human leptospirosis that caused by spirochete pathogen Leptospira interrogans is a worldwide zoonosis of global concern [2,3].…”

Section: Introductionmentioning

confidence: 99%

Virtual screening for potential inhibitors of homology modeled Leptospira interrogans MurD ligase

2010

View full text Add to dashboard Cite

The life-threatening infections caused by Leptospira serovars remain a global challenge since long time. Prevention of infection by controlling environmental factors being difficult to practice in developing countries, there is a need for designing potent anti-leptospirosis drugs. ATP-dependent MurD involved in biosynthesis of peptidoglycan was identified as common drug target among pathogenic Leptospira serovars through subtractive genomic approach. Peptidoglycan biosynthesis pathway being unique to bacteria and absent in host represents promising target for antimicrobial drug discovery. Thus, MurD 3D models were generated using crystal structures of 1EEH and 2JFF as templates in Modeller9v7. Structural refinement and energy minimization of the model was carried out in Maestro 9.0 applying OPLS-AA 2001 force field and was evaluated through Procheck, ProSA, PROQ, and Profile 3D. The active site residues were confirmed from the models in complex with substrate and inhibitor. Four published MurD inhibitors (two phosphinics, one sulfonamide, and one benzene 1,3-dicarbixylic acid derivative) were queried against more than one million entries of Ligand.Info Meta-Database to generate in-house library of 1,496 MurD inhibitor analogs. Our approach of virtual screening of the best-ranked compounds with pharmacokinetics property prediction has provided 17 novel MurD inhibitors for developing anti-leptospirosis drug targeting peptidoglycan biosynthesis pathway.

show abstract

Treatment of health-care-associated infections caused by Gram-negative bacteria: a consensus statement

Cited by 207 publications

References 59 publications

Characterization and sensitivity to antibiotics of bacteria isolated from the lower respiratory tract of ventilated patients hospitalized in intensive care units

Characterization and sensitivity to antibiotics of bacteria isolated from the lower respiratory tract of ventilated patients hospitalized in intensive care units

Surveillance of multidrug resistant uropathogenic bacteria in hospitalized patients in Indian

Virtual screening for potential inhibitors of homology modeled Leptospira interrogans MurD ligase

Contact Info

Product

Resources

About