Treatment of Human Chronic Fascioliasis with Triclabendazole: Drug Efficacy and Serologic Response

Human liver flukes

“…Double-dose therapy (10mg/kg dose given, and repeated at 12-24 hours) is recommended in heavy infections, or if there is no response to single-dose therapy (116) . Cure rates of 92·2-100% are described in adults with a two-dose regimen (117,118) , with 79·2% cure rates described with the single-dose regimen (119) . Cure rates of 95% using the 10mg/kg dose have recently been described in children, with 100% cure rates using two doses of 7.5mg/kg (120) .…”

Seroepidemiology of Fasciola Hepatica in Mersin province and surrounding towns and the role of family history of the Fascioliasis in the transmission of the parasite

“…In addition, parasite eggs may not be detected when the parasite lays at intervals in cases of chronic fascioliasis and when the parasite has an ectopic location (3,7,22,23). In the seroepidemiological study in the province of Antalya, stool was examined in 16 patients in whom serum IgG antibodies to Fasciola hepatica were found using ES-ELISA method, but only 4 (25%) had eggs of Fasciola he- Table 3.…”

“…At present, serological tests are known to be the most valuable diagnostic tests and can be used in all stages of the disease, including the acute stage when the eggs are not yet excreted in the stool, and in the evaluation of the treatment outcome (3,23).…”

Efficacy and tolerability of two single-day regimens of triclabendazole for fascioliasis in Peruvian children

“…Case reports (51) , small series (28) (44) (49) (52) , and larger trials of TCBZ treatment in pediatric populations have been described. A cure rate of 79.2% was obtained in 24 individuals (14 children, 11-16 years old) in Chile with a single 10-mg/kg TCBZ dose (Fasinex®) administered after an overnight fast, which might have altered the absorption of the drug (53) ; similarly, a cure rate of 77.5% was obtained after a single 10-mg/kg post-prandial dose in 40 children (4-15 years old) (54) . One of the largest series to assess the effi cacy of TCBZ included 38 children (aged 0-15 years) in Peru, with an overall cure rate of 83% (50) .…”

“…An exhaustive literature review with no language restriction produced a total of 554 (441 adults and 113 children) documented cases between 1986 and 2002 from Germany (32) (33) (61) , Switzerland (62) , France (63) (64) , Belgium (41) , Australia (29) , Venezuela (65) , Spain (66) (67) (68) , the US (69) , Japan (24) , Iran (45) (70) , Chile, (53) and Egypt (28) (44) (54) (55) , that received the veterinary formulation with no or minimal adverse events. In Peru, it has been administered since 1996 (8) (42) .…”