Treatment of Hyperthyroidism with Individually Calculated Doses of I131

Bauer, Franz K.

doi:10.1001/archinte.1957.00260020030005

Cited by 14 publications

(2 citation statements)

References 13 publications

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“…However, in a series of 1,000 necropsies on euthyroid patients whose thyroids had been impalpable during life, Mortensen et al (1955) noted that the largest number weighed between 15 and 35 g. Bauer and Blahd (1957) prepared scintigrams of 106 cases and report a range of gland sizes beginning at 15 g. The normal thyroid gland probably varies considerably in size in different parts of the world, and these American figures are not necessarily applicable to the Sheffield region. Nevertheless, the evidence obtained from our own scintillation studies and necropsy observations on hyperthyroid patients indicates that a lower figure for the impalpable thyroid would have been more appropriate.…”

Section: Discussionmentioning

confidence: 99%

“…These came from many centres in North America and Europe, and included many criteria for the selection of cases and different methods of treatment. The reports which have appeared vary from the study of small groups of patients treated by detailed techniques (Bauer and Blahd, 1957) to reports on tile results obtained from the use of simple methods involving the minimum of equipment and measurement (Macgregor, 1957).…”

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Treatment of Thyrotoxicosis with 131I

Blomfield¹,

Eckert²,

Fisher³

et al. 1959

BMJ

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Treatment of Thyrotoxicosis with 131I

Blomfield¹,

Eckert²,

Fisher³

et al. 1959

BMJ

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Thyrotoxicosis Treated with Small Repeated Doses of Radioiodine

DeGowin¹

1959

Arch Intern Med

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An ultimate objective in the treatment of hyperthyroidism with radioactive I131 has been to develop a method of selecting for each patient a dose of the isotope which will destroy precisely enough thyroid tissue to produce the euthyroid state. The application of such a method would eradicate the therapeutic sequelae of radiation thyroiditis, thyroid storm, and myxedema. Protraction of the hyperthyroid state would not occur in patients who now require supplementary doses to correct for the inadequacy of the initial attempt.Although a search for a satisfactory method of dose prediction has been in progress since radioiodine was first used, in 1941, in the Massachusetts General Hospital,5 no ideal solution has yet been found. The thyroidal uptake of I131 can be measured by tracer doses of the isotope, but the mass of the thyroid gland can only be estimated with great error, either by palpation or by the use of the scintogram. Furthermore, it seems likely that variable reactions of the acinar cells of the gland are not adequately reflected by the scintogram. As a result, each group of workers has evolved a different system of treatment based upon its clinical experience. The selection of pa¬ tients for treatment with I131 is not uniform.Criteria for evaluation of thyroid function vary both for clinical signs and laboratory tests. The time intervals between supple¬ mentary treatments are considerably dif¬ ferent from clinic to clinic. The follow-up period of treated patients depends upon local convenience. Disagreement concerning the desirable ratio between the number of patients overtreated and undertreated has led to a variety of dosages of I131.The multiplicity of dosage systems, to¬ gether with the current concern for exces¬ sive radiation of all kinds, encourages us to record our experiences in giving somewhat smaller doses of I181 than have been re¬ ported in most series of patients. Care of the PatientsThe Thyroid Clinic of the University Hospitals was organized in 1949, and has been functioning since at an accelerating rate. The annual numbers of patient-visits for all types of thyroid disease were 280 (1957). Most of the patients were born in Iowa, although a minority are natives of Western Illinois. Caucasian stocks predom¬ inate; less than 1% are Negroes. The great majority are ambulatory and are treated as outpatients, either indigent or private.Each patient is first examined in the clinical service to which he or she is ad¬ mitted. A physician takes the history, makes the physical examination, and secures

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Prognostic Value of 24-Hour Radioactive Iodine Uptake

J¹

1964

Arch Intern Med

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Treatment of Hyperthyroidism with Individually Calculated Doses of I131

Cited by 14 publications

References 13 publications

Treatment of Thyrotoxicosis with 131I

Treatment of Thyrotoxicosis with 131I

Thyrotoxicosis Treated with Small Repeated Doses of Radioiodine

Prognostic Value of 24-Hour Radioactive Iodine Uptake

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