Treatment of immature and mature Fasciola hepatica infections in sheep with triclabendazole

Abstract

A new benzimidazole anthelmintic, triclabendazole (CGA-89317) was found to be highly efficient against mature and early immature Fasciola hepatica infections in sheep. At the dose rate of 2.5 mg/kg the efficiency was 90 and 98 per cent against flukes aged eight and 12 weeks respectively. At 5 mg/kg the drug was 92 and 98 per cent efficient against flukes aged four and eight weeks respectively and 100 per cent against 12-week-old flukes. An efficiency of 93 and 98 per cent was achieved against one-week-old flukes and 99 to 100 per cent against flukes aged two to four weeks at 10 mg/kg. At this dose rate the drug had 100 per cent efficiency against six-week-old flukes. If the dose was increased to 15 mg/kg, 98 per cent efficiency was achieved one day after infection. Triclabendazole was equally efficient when administered orally or by intraruminal or intra-abomasal injection. The maximum tolerated dose of 200 mg/kg was established.

Activity of artemether and OZ78 against triclabendazole-resistant Fasciola hepatica

“…Table 1 shows that administration of a single 10 mg/kg oral dose of triclabendazole to rats harbouring an adult triclabendazole-sensitive F. hepatica infection, resulted in a worm burden reduction of 95.3% (KW = 6.75; P = 0.009). This finding is in accordance with previous studies with triclabendazole-susceptible F. hepatica isolates, which reported complete worm burden reductions with 10 mg/kg single oral doses of triclabendazole (Boray et al, 1983;Turner et al, 1984).…”

The efficacy and tolerability of triclabendazole in Cuban patients with latent and chronic Fasciola hepatica infection.

“…In this setting, it is effective as a single dose therapy against both mature and immature forms of adult worms. 11 The helminthicidal mechanism of action is at present unclear, but the pharmacologically active TCZ sulfoxide and sulfone metabolites may act either by uncoupling oxidative phosphorylation in mitochondria, leading to loss of respiratory control or by binding to parasite tubulin monomers, thereby disrupting the tegmentum of both immature and mature flukes. [12][13][14] …”

Efficacy of a Single Oral Dose of Oxfendazole against Fasciola hepatica in Naturally Infected Sheep

“…Albendazole is recommended for the control of F. hepatica in domestic animals 18 ; however, its anthelmintic effect is only for chronic fascioliasis (adult stages) and is not effective to acute and sub-acute fascioliasis (immature stages). 19,20 Currently, fascioliasis is mainly treated using the TCBZ because of its ability to act in both stages, immature and mature F. hepatica. 20 This drug has been used since the 80s and it has shown good activity against liver fluke for many years.…”