Treatment of Immune Deficiency Disease with Bone Marrow Stem Cell Concentrates

Bekkum, D. W. van; Ka, Dicke

doi:10.1002/9780470719886.ch12

Cited by 4 publications

(1 citation statement)

References 35 publications

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“…Attempts have been made to avoid acute GVH reactions by separating stem cells from the immune competent cells, which were the mediators of the GVH reaction. The grafts were composed as far as possible of concentrated stem cells (Bekkum & Dicke, 1972). Using this technique, two out often patients with combined immuno-deficiency have survived for longer than i year, but delayed GVH reactions still occurred in a proportion of the patients.…”

Section: Groupmentioning

confidence: 99%

Chronic muco-cutaneous candidiasis: new approaches to treatment

Higgs¹,

Wells²

2006

British Journal of Dermatology

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SUMMARY Chronic muco‐cutaneous candidiasis may be associated with several defined syndromes of immunodeficiency or may be the predominant feature in a group of diseases, some of which are genetically determined. Current therapeutic approaches are discussed in relation to each clinical group, with particular reference to immunological reconstitution, correction of iron deficiency and other nutritional deficiencies. The effects of two new antifungal agents are considered, as well as the use of parenteral amphotericin B in a low dose. The possible use of combined therapy is outlined in patients who are more severely affected.

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Section: Groupmentioning

confidence: 99%

Chronic muco-cutaneous candidiasis: new approaches to treatment

Higgs¹,

Wells²

2006

British Journal of Dermatology

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A method for cloning T‐lymphocytic precursors in agar

Löwenberg

Zeeuw

1979

American J Hematol

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A new technique for the culture of T-lymphocytic colonies is reported. The method may be regarded as a human lymphocyte precursor cell assay, as is the myeloid colony culture for granulocyte-macrophage progenitors. The colonies arise under the simultaneous stimulation of phytohemagglutin and a leukocyte feeder. A linear relationship is found between colony numbers and cell numbers plated. The colonies represent aggregates of lymphoblast-like cells, the majority of which are capable of E-rosette formation, are responsive in mixed lymphocyte cultures, and do not exhibit surface immunoglobulins. Their density distribution profile is very similar to that of myeloid colony-forming cells. The finding that most of these colony-forming cells are recovered in the so-called lymphocyte-free stem cell fraction following density fractionation suggests that they originate from a lymphocytic precursor.

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