Treatment of Influenza. The Therapeutic Efficacy of Rimantadine HCl in a Naturally Occurring Influenza A2 Outbreak

Crystal structure of 1-(adamantan-1-yl)-3-(3-chlorophenyl)thiourea, C17H21ClN2S

“…In addition, adamantanyl moiety represents the major pharmacophore of various antiviral drugs as amantadine [5][6][7], rimantadine [8,9] and tromantadine [10]. Moreover, several adamantane-based drugs are currently utilized as important therapies against .…”

Crystal structure of 4-bromobenzyl (Z)-N′-(adamantan-1-yl)-4-phenylpiperazine-1-carbothioimidate, C28H34BrN3S

“…Several adamantane derivatives have long been known for their antiviral activity against the in uenza A [3][4][5][6], human immunode ciency (HIV) [7][8][9] and herpes simplex [10] viruses. Several adamantane-based drugs are currently used as useful medications for the control of central nervous disorders [10][11][12][13].…”

Crystal structure of 1-(adamantan-1-yl)-3-(4-bromophenyl)thiourea, C17H21BrN2S

“…The adamantanyl moiety represents the major pharmacophore of various drugs as amantadine [1][2][3], rimantadine [4,5] and tromantadine [6], which are currently described as e cient antiviral therapies. Moreover, several adamantanebased drugs are currently employed as important medications against malaria infections [7], central nervous disorders [8][9][10], hyperglycaemia [11] and drug-resistant TB strain infections [12].…”