Treatment of Intrabony Defects Using Guided Tissue Regeneration or Enamel Matrix Derivative: A 3‐Year Prospective Randomized Clinical Study

Crea, Alessandro; Dassatti, Leonardo; Hoffmann, Oliver; Zafiropoulos, Gregory-George; Deli, Giorgio

doi:10.1902/jop.2008.080135

Cited by 41 publications

(86 citation statements)

References 40 publications

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“…A similar PAL gain was obtained from PRP‐treated sites (3.21 ± 0.58 mm) in our previous study 4 . In contrast, less PAL gain was reported with the treatment of EMD (2.9 ± 1.4 mm) and GTR (2.5 ± 1.2 mm) at 1 year 39 . The mean percentage change in IBD fill was 48.2% ± 5.72% in the test group compared to the control group (1.80% ± 1.56%) (Table 3).…”

Section: Discussionsupporting

confidence: 86%

Treatment of 3‐Wall Intrabony Defects in Patients With Chronic Periodontitis With Autologous Platelet‐Rich Fibrin: A Randomized Controlled Clinical Trial

Sharma

Pradeep

2011

Journal of Periodontology

182

168

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Section: Discussionsupporting

confidence: 86%

Treatment of 3‐Wall Intrabony Defects in Patients With Chronic Periodontitis With Autologous Platelet‐Rich Fibrin: A Randomized Controlled Clinical Trial

Sharma

Pradeep

2011

Journal of Periodontology

182

168

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“…The treatment modalities known to improve perithe mineralized conditioned medium than DPSCs and PAFSCs, while PAFSCs showed higher colonogenic efodontal regeneration, such as xenogenic bone particle graft, growth factors such as TGF-β, BMP-2, and PDGF ficiency and proliferation rate. Our hypothesis started from these in vitro results, that aDSCs-mediated perigraft with guided bone regeneration were reported to help form the new alveolar bone (8,10,11,14,15,28,31), odontal regeneration might be effective to treat advanced periodontitis but the regenerating capacity should be difbut the clinical results were generally unsatisfactory. The reasons of the failure are due to, firstly, insufficient ferent among the three aDSCs.…”

Section: Generation Of Periodontitis In Beagle Dogmentioning

confidence: 99%

“…tissue regeneration (GTR), topical application of enamel matrix derivative (EMD), or various growth factors can partially regenerate periodontal tissues (8,10,11,14,15, Oral diseases are included among the World Health Organization (WHO) definition of chronic diseases, and 27,30). The results in clinical applications vary greatly, depending on the different characteristics of the defects the associations between oral health status and chronic systemic diseases have been observed recently (48,49).…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Periodontal Stem Cell Transplantation in the Treatment of Advanced Periodontitis

2011

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Periodontitis is the most common cause for tooth loss in adults and advanced types affect 10-15% of adults worldwide. The attempts to save tooth and regenerate the periodontal apparatus including cementum, periodontal ligament, and alveolar bone reach to the dental tissue-derived stem cell therapy. Although there have been several periodontitis models suggested, the apical involvement of tooth root is especially challenging to be regenerated and dental stem cell therapy for the state has never been investigated. Three kinds of dental tissue-derived adult stem cells (aDSCs) were obtained from the extracted immature molars of beagle dogs (n = 8), and ex vivo expanded periodontal ligament stem cells (PDLSCs), dental pulp stem cells (DPSCs), and periapical follicular stem cells (PAFSCs) were transplanted into the apical involvement defect. As for the lack of cementum-specific markers, anti-human cementum protein 1 (rhCEMP1) antibody was fabricated and the aDSCs and the regenerated tissues were immunostained with anti-CEMP1 antibody. Autologous PDLSCs showed the best regenerating capacity of periodontal ligament, alveolar bone, and cementum as well as peripheral nerve and blood vessel, which were evaluated by conventional and immune histology, 3D micro-CT, and clinical index. The rhCEMP1 was expressed strongest in PDLSCs and in the regenerated periodontal ligament space. We suggest here the PDLSCs as the most favorable candidate for the clinical application among the three dental stem cells and can be used for treatment of advanced periodontitis where tooth removal was indicated in the clinical cases.

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“…The PDL itself contains an organized structure of collagen fibres, which essentially attach a tooth to the alveolar bone. Current clinical periodontal therapy cannot promote the complete regeneration of periodontal tissues (Cortellini and Tonetti, 2000;Sanz and Giovannoli, 2000;Crea et al, 2008;Dori et al, 2008). Therefore, new approaches and materials are required to regenerate the lost periodontal tissues (Bartold et al, 2006;Edwards and Mason, 2006).…”

Section: Introductionmentioning

confidence: 99%

The effect of electrospun fibre alignment on the behaviour of rat periodontal ligament cells

Shang

Yang²,

Cheng³

et al. 2010

eCM

119

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It is envisioned that for the regeneration of highly organized structures, like tendon and ligaments, only aligned fibrous scaffolds can provide adequate topographic guidance to cells. In this study, a novel method to electrospin an aligned scaffold is presented. Electrospun fibres were deposited into a water bath and then the fibres were drawn to a rotating mandrel in a controlled manner. In this way, parallel and cross-aligned fibrous poly (lactide-co-glycolide) (PLGA) scaffolds were fabricated, which were subsequently used to study their effect on the growth behaviour of rat periodontal ligament (PDL) cells. First, the scaffolds were characterized regarding mechanical properties, scaffold stability and degradation in vitro. Then, rat PDL cells were seeded and cultured on these scaffolds for up to 7 days. Randomly oriented PLGA and solvent cast plain PLGA films served as controls. Results showed that the alignment of fibres resulted in a higher tensile stress and Young's modulus. Aligned scaffolds maintained their structural stability better compared to the controls after incubation in phosphate-buffered saline for 6 weeks. Further, cells were observed to elongate along the fibre after 3 days of culture. Proliferation and migration of PDL cells was significantly more prevalent on the aligned fibres compared to the controls. It was concluded that aligned scaffolds seem to be able to promote the organized regeneration of periodontal tissue.

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Treatment of Intrabony Defects Using Guided Tissue Regeneration or Enamel Matrix Derivative: A 3‐Year Prospective Randomized Clinical Study

Cited by 41 publications

References 40 publications

Treatment of 3‐Wall Intrabony Defects in Patients With Chronic Periodontitis With Autologous Platelet‐Rich Fibrin: A Randomized Controlled Clinical Trial

Treatment of 3‐Wall Intrabony Defects in Patients With Chronic Periodontitis With Autologous Platelet‐Rich Fibrin: A Randomized Controlled Clinical Trial

Efficacy of Periodontal Stem Cell Transplantation in the Treatment of Advanced Periodontitis

The effect of electrospun fibre alignment on the behaviour of rat periodontal ligament cells

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