Treatment of iron deficiency anemia with liposomal iron in inflammatory bowel disease: efficacy and impact on quality of life

Antunes, Carla Valéria de Alvarenga; Nascimento, Cristiano Rodrigo de Alvarenga; Ribeiro, Tarsila Campanha da Rocha; Antunes, Priscila de Alvarenga; Chebli, Liliana Andrade; Fava, Lidiane Martins Gonçalves; Malaguti, Carla

doi:10.1007/s11096-020-01044-x

Cited by 13 publications

(17 citation statements)

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“…Additionally, the quality of life of the patients was increased, and a decrease in fatigue was seen in some patients. Moreover, no adverse effects were observed in the patients . Liposomal iron confers stability to the molecule and the ability to release the content gradually.…”

Section: Recent Studies On Improving Iron Bioavailabilitymentioning

confidence: 90%

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Iron Absorption: Factors, Limitations, and Improvement Methods

et al. 2022

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Iron is an essential element for human life since it participates in many functions in the human body, including oxygen transport, immunity, cell division and differentiation, and energy metabolism. Iron homeostasis is mainly controlled by intestinal absorption because iron does not have active excretory mechanisms for humans. Thus, efficient intestinal iron bioavailability is essential to reduce the risk of iron deficiency anemia. There are two forms of iron, heme and nonheme, found in foods. The average daily dietary iron intake is 10 to 15 mg in humans since only 1 to 2 mg is absorbed through the intestinal system. Nutrient–nutrient interactions may play a role in dietary intestinal iron absorption. Dietary inhibitors such as calcium, phytates, polyphenols and enhancers such as ascorbic acid and proteins mainly influence iron bioavailability. Numerous studies have been carried out for years to enhance iron bioavailability and combat iron deficiency. In addition to traditional methods, innovative techniques are being developed day by day to enhance iron bioavailability. This review will provide information about iron bioavailability, factors affecting absorption, iron deficiency, and recent studies on improving iron bioavailability.

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Section: Recent Studies On Improving Iron Bioavailabilitymentioning

confidence: 90%

“…Moreover, no adverse effects were observed in the patients. 146 Liposomal iron confers stability to the molecule and the ability to release the content gradually. In addition, the gradual release aids in better absorption.…”

Section: Recent Studies On Improving Iron Bioavailabilitymentioning

confidence: 99%

Iron Absorption: Factors, Limitations, and Improvement Methods

et al. 2022

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“…Iron delivery via liposomes is a promising approach to improve iron absorption. [23][24][25]132 Liposomal iron is prepared by microencapsulation of iron within a liposomal phospholipid bilayer, 25 resulting in nano-sized particles (100-1000 nM in diameter). Microencapsulation is purported to stabilize the inorganic iron atom and increase bioavailability and absorption, while producing fewer negative side effects.…”

Section: Liposomal/microparticle Np Oral Iron Deliverymentioning

confidence: 99%

“…Microencapsulation is purported to stabilize the inorganic iron atom and increase bioavailability and absorption, while producing fewer negative side effects. 25,132 Liposomal/ NP iron is likely absorbed into enterocytes by endocytosis or via the M cell/lymphatic pathway, as detailed below (Figure 1E). 133 In patients with IBD, daily supplementation with oral liposomal iron taken twice daily for 8 weeks (28 mg/day) improved Hb levels, TSAT and serum iron values.…”

Section: Liposomal/microparticle Np Oral Iron Deliverymentioning

confidence: 99%

Oral iron therapy: Current concepts and future prospects for improving efficacy and outcomes

Ebea‐Ugwuanyi,

Vidyasagar,

Connor

et al. 2024

Br J Haematol

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SummaryIron deficiency (ID) and iron‐deficiency anaemia (IDA) are global public health concerns, most commonly afflicting children, pregnant women and women of childbearing age. Pathological outcomes of ID include delayed cognitive development in children, adverse pregnancy outcomes and decreased work capacity in adults. IDA is usually treated by oral iron supplementation, typically using iron salts (e.g. FeSO4); however, dosing at several‐fold above the RDA may be required due to less efficient absorption. Excess enteral iron causes adverse gastrointestinal side effects, thus reducing compliance, and negatively impacts the gut microbiome. Recent research has sought to identify new iron formulations with better absorption so that lower effective dosing can be utilized. This article outlines emerging research on oral iron supplementation and focuses on molecular mechanisms by which different supplemental forms of iron are transported across the intestinal epithelium and whether these transport pathways are subject to regulation by the iron‐regulatory hormone hepcidin.

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“…По разным данным, частота диспепсических явлений составляет 8-17% [23][24][25], запоров -4-20% [24][25][26]. Решением данной проблемы могут стать новые формы препаратов железа, например липосомальные [27], хелаторные [28] и наноформы [29], которые показали свою эффективность и часто более высокую переносимость по сравнению с традиционными формами.…”

Section: обсуждение основного результата исследованияunclassified

The Role of Latent Iron Deficiency and Its Subsequent Correction in Adolescent Boys' Functional Performance

Shadrina

Balashova

2022

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Background. Iron deficiency remains the most frequent nutrient deficiency in the world. Its negative impact on the physical and psychomotor development determines the importance of its timely, fast, and complete correction. Thus, the clinical efficacy of iron supplementation and its effect on body function, especially in latent iron deficiency (LID), is still insufficiently studied.Objective. The aim of the study is to identify the effect of iron supplementation in various dosages on functional performance of healthy adolescent boys but considering the initial iron levels.Methods. The study covered teenage boys 12–17 years old from I and II health groups studying in Samara Cadet Corps. All children were divided into groups according to the examination results (CBC, serum ferritin level): study group — 20 children with iron deficiency (3 children with iron deficiency anemia (IDA) were not included in this analysis), and the control group — 99 children. All children received iron supplements for 30 days: children with LID — 2.5 mg/kg/day, healthy children — 15 mg/day.Results. Normalization of serum ferritin was achieved only in 75% (16) of children after 30 days of iron intake. The mean timed expiratory capacity was 20" (16 ± 25) in healthy and 17.5" (11.25 ± 21.75) in iron deficiency (p = 0.081) group. There is a tendency to prolong the breath retention time on exhalation after supplementation in LID group (p = 0.068). The recovery time of heart rate before supplementation was 118.8 ± 71.7" in study group and 168.0 ± 98.5" in control group (p = 0.045) according to the results of the Martin – Kushelevsky test. After supplementation it has decreased only in study group (p = 0.009). The children's muscle strength in compared groups did not differ before (p = 0.486) and after (p = 0.567) supplementation, however, it has increased in the control group regarding the initial values (p = 0.003). Physical fitness indicators in both groups did not differ before supplementation. Study group significantly improved the running time by 60 m (p = 0.038) after supplementation. Control group has shown positive dynamics for three indicators: pulling out from suspension on high bar (p = 0.019), long jump (p = 0.026), and running at 60 m (0.018). Moreover, there were no differences between study and control groups after supplementation.Conclusion. Iron deficiency has moderate negative effect on adaptive respiratory and cardiovascular capabilities and fatigue. Iron supplementation mainly improves the indicators of cardiovascular system in case of iron deficiency, and indicators of muscle strength and physical fitness in case of normal iron levels.

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Treatment of iron deficiency anemia with liposomal iron in inflammatory bowel disease: efficacy and impact on quality of life

Cited by 13 publications

References 39 publications

Iron Absorption: Factors, Limitations, and Improvement Methods

Iron Absorption: Factors, Limitations, and Improvement Methods

Oral iron therapy: Current concepts and future prospects for improving efficacy and outcomes

The Role of Latent Iron Deficiency and Its Subsequent Correction in Adolescent Boys' Functional Performance

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