Treatment of Irritable Bowel Syndrome by Chinese Medicine: A Review

Chen, Guan‐Ru; Xie, Xing; Peng, Cheng

doi:10.1007/s11655-021-3521-4

Cited by 11 publications

(7 citation statements)

References 36 publications

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“…The fundamental goal of pattern-based treatment is to define the main etiology and pathophysiology in order to choose the best specific treatment strategy for each patient. To achieve optimum therapeutic benefits, different IBS patterns based on traditional medicine theory should be treated with different herbal prescriptions that are appropriate for each pattern ( Chen G. et al, 2021 ). However, only two SR ( Huang and Zhang, 2011 ; Xiao Y. et al, 2015 ) evaluated a specific pattern-based therapy: soothing the liver and strengthening the spleen ( Shugan Jianpi ) therapy.…”

Section: Discussionmentioning

confidence: 99%

An Overview of Systematic Reviews of Herbal Medicine for Irritable Bowel Syndrome

Jun

Kim

et al. 2022

Front. Pharmacol.

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Background: Irritable bowel syndrome (IBS) is a common disorder with abdominal pain and bowel habits changes. Herbal medicines (HMs) are frequently used in the treatment of IBS. Therefore, several systematic reviews (SRs) have been conducted to assess the efficacy and safety of HM in IBS patients. This study aimed to investigate the methodology and quality of evidence of SRs, and to describe the current state of research and evidence for the treatment of IBS with HM.Methods: SRs published up to January 2022 were searched using six electronic databases. SRs and/or meta-analyses on the use of HMs for IBS were included. The effects of placebo, conventional medicine (CM), and probiotics were compared with those of HMs. Two investigators independently extracted the data and assessed methodological quality using the Measure Tool to Assessment System Reviews 2 (AMSTAR 2). Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) was used to evaluate the quality of evidence for each main finding.Results: Eighteen SRs were included in this overview. Among them, eight SRs reported only specific subtypes of IBS: six SRs reported patients with diarrhea-predominant IBS, and two SRs reported patients with constipation-predominant IBS. In terms of total efficacy, HM was more effective than placebo, CM, or probiotics. HM showed a more significant effect than CM in relieving independent IBS symptom score (abdominal pain score, diarrhea score, abdominal distension score, stool frequency score, etc.) and recurrence rate. The rate of adverse events was significantly lower with HM compared to CM, and no serious adverse events were reported with HM treatment. According to AMSTAR 2, the methodological quality of the included SRs was extremely low. Furthermore, the quality of evidence for total efficacy was considered low or very low according to the GRADE tool.Conclusion: HM can be considered as an effective and safe treatment for IBS. However, the methodological quality of the included SRs and the quality of evidence was generally low. Therefore, well-designed randomized controlled trials are needed in the future so that a high-quality SR can be used to better assess the safety and efficacy of HM in the treatment of IBS.Systematic Review Registration:https://osf.io/nt6wz, identifier 10.17605/OSF.IO/NT6WZ.

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Section: Discussionmentioning

confidence: 99%

An Overview of Systematic Reviews of Herbal Medicine for Irritable Bowel Syndrome

Jun

Kim

et al. 2022

Front. Pharmacol.

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“…Die Analyse von Studien zeigt, dass v. a. Rezepturen, Akupunktur und Moxibustion als primäre Methoden zur Behandlung des RDS in der TCM zur Anwendung gelangen. Mithilfe dieser Verfahren gelingen die Regulierung des enterischen Nerven- und des Immunsystems, die Linderung viszeraler Überempfindlichkeit sowie die Optimierung der Stabilität der Darmflora 7 .…”

Section: Behandlungsoptionen In Der Tcmunclassified

Behandlung funktioneller Bauchschmerzen im Kindes- und Jugendalter mit TCM

Schmid¹,

Agarwal²

2022

AkupunkturPraxis

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Die nachstehende Fallvorstellung zeigt die Interventionsmöglichkeit mittels TCM bei funktionellen Bauchschmerzen einer Jugendlichen auf. Abdominale Schmerzen zählen zu den am häufigsten beklagten Beschwerden im Kindes- und Jugendalter. Oft lässt sich kein morphologisches Korrelat finden, was zu großen Sorgen und Nöten sowohl bei den Patienten als auch den Eltern führt. Zudem ist die Lebensqualität von Kindern mit funktionellen Abdominalbeschwerden (functional gastrointestinal diseases [FGID]) deutlich reduziert. Nach Ausschluss möglicher organischer Ursachen wird anhand der nachfolgenden Fallbeschreibung dargestellt, welche Therapieoptionen die TCM beim Reizdarmsyndrom bietet.

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“…Direct medical costs attributed to IBS in the USA (excluding prescription and over-the-counter medications) have been estimated to be $1.5–$10 billion per year [ 6 ]. The direct and indirect costs related to IBS has been estimated to be up to ¥123 billion in China [ 7 ]. According to a meta-analysis of 80 clinical studies involving 260,960 individuals in 2012 [ 8 ], the IBS prevalence in China was 6.5%.…”

Section: Introductionmentioning

confidence: 99%

“…Traditional Chinese medicine (TCM) formulations have shown favorable effects in IBS treatment [ 22 – 24 ]. According to TCM theory, the etiology of IBS is attributed mainly to the weakness of Pi (spleen) and Wei (stomach) or damage to the Gan (liver) [ 7 , 25 ], which is summarized as “Dan Re Pi Han” in TCM theory.…”

Section: Introductionmentioning

confidence: 99%

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Chaihu-Guizhi-Ganjiang Decoction is more efficacious in treating irritable bowel syndrome than Dicetel according to metabolomics analysis

Zhu

Li³

et al. 2022

Chin Med

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Background Chaihu-Guizhi-Ganjiang Decoction (CGGD) is a traditional Chinese medicine (TCM) prescription used to treat viral influenza. There is evidence that CGGD can be used to treat irritable bowel syndrome (IBS) but the potential mechanism of action and metabolites produced upon CGGD treatment remains elusive. Methods Patients with IBS were treated with pinaverium bromide (Dicetel™) and then CGGD after a washout period of 1 week. Both treatments lasted for 30 days. The efficacy and changes of metabolites in plasma after the two treatments were compared. Plasma samples were acquired before and after each treatment, and untargeted metabolics analysis was performed. Results Efficacy was measured according to the Rome IV criteria and TCM theory. Our results indicated that CGGD showed significantly better efficacy than Dicetel in the treatment of IBS utilizing each criterion. CGGD exerted greater effects on plasma metabolism than Dicetel. Dicetel treatment led to increased tryptophan metabolism (increased levels of 5-Hydroxyindoleacetaldehyde) and increased protein metabolism (increased levels of L-arginine). CGGD treatment significantly (p < 0.05) increased carnitine metabolism, with elevated levels of L-carnitine and acylcarnitine in plasma. Such changes in these metabolites could exert effects against IBS by improving gastrointestinal motility and suppressing pain, depression, and inflammation. Conclusions CGGD appeared to be more efficacious than Dicetel for treating patients with IBS. The findings provide a sound support for the underlying biomolecular mechanism of CGGD in the prevention and treatment of IBS.

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Treatment of Irritable Bowel Syndrome by Chinese Medicine: A Review

Cited by 11 publications

References 36 publications

An Overview of Systematic Reviews of Herbal Medicine for Irritable Bowel Syndrome

An Overview of Systematic Reviews of Herbal Medicine for Irritable Bowel Syndrome

Behandlung funktioneller Bauchschmerzen im Kindes- und Jugendalter mit TCM

Chaihu-Guizhi-Ganjiang Decoction is more efficacious in treating irritable bowel syndrome than Dicetel according to metabolomics analysis

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