Treatment of Juvenile Myoclonic Epilepsy

Auvin, Stéphane

doi:10.1111/j.1755-5949.2008.00046.x

Cited by 15 publications

(9 citation statements)

References 70 publications

(76 reference statements)

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“…Juvenile myoclonic epilepsy usually requires lifelong treatment because seizures nearly always return after withdrawal of therapy. 22 Valproate and lamotrigine have shown to produce a complete remission of seizures in a majority of patients. It may be possible that our patient is experiencing a remission phase due to the medication she has been taking.…”

Section: Discussionmentioning

confidence: 99%

“…Because of the cyclic nature of JME, we do not know if the improvements seen in this patient are from the SMT or if we are entering a cyclic phase sometimes seen with seizure disorders. 22 A JME patient will need lifelong follow-up care for the possibility of reoccurrence of seizure episodes. This follow-up care would enable the patient to be treated if she had entered an absence phase of her seizures or reoccurring episodes begin; current literature states that this is likely.…”

Section: Limitationsmentioning

confidence: 99%

“…This follow-up care would enable the patient to be treated if she had entered an absence phase of her seizures or reoccurring episodes begin; current literature states that this is likely. 2,22 In our attempt to use outcome measures for this study, we chose to use the BNQ and HDI and replace pain with seizure. Anytime an outcome instrument is revised or used in an alternate setting, its validity and reliability need to be studied.…”

Section: Limitationsmentioning

confidence: 99%

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Upper cervical chiropractic care for a 25-year-old woman with myoclonic seizures

Hubbard

Crisp

Vowles

2010

Journal of Chiropractic Medicine

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Objective: The purpose of this case report is to describe the chiropractic management using upper cervical techniques of a 25-year-old woman diagnosed with juvenile myoclonic epilepsy (JME). Clinical Features: A 25-year-old woman had a history of JME, which was diagnosed at the age of 14 years. Her seizure episodes began shortly after trauma to her cervical spine and the onset of menarche. Intervention and Outcome: After case history and physical examination, the patient received high-velocity, low-amplitude chiropractic spinal manipulation to her upper cervical spine using the Blair upper cervical chiropractic technique protocol. There was improvement in her seizure episodes and menstrual cycles following 12 weeks of chiropractic care.Conclusion: This case study demonstrated improvement in a young woman with a seizure disorder after she received upper cervical chiropractic manipulation. This case suggests the need for more rigorous research to examine how upper cervical chiropractic techniques may provide therapeutic benefit to patients with seizure disorders.

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Section: Discussionmentioning

confidence: 99%

Section: Limitationsmentioning

confidence: 99%

Section: Limitationsmentioning

confidence: 99%

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Upper cervical chiropractic care for a 25-year-old woman with myoclonic seizures

Hubbard

Crisp

Vowles

2010

Journal of Chiropractic Medicine

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“…However, the use of VPA particularly in fertile age groups increases the risk of fetal malformation and may delay the neuronal development of the fetus (Duncan, 2007). Therefore, the usage of new generation antiepileptic drugs such as lamotrigine (LTG) levetiracetam, topiramate have been advocated especially in young women (Auvin, 2008). However, LTG may increase the frequency of myoclonic and GTC seizures (Mantoan and Walker, 2011).…”

Section: Introductionmentioning

confidence: 99%

Lamotrigine induced seizures in juvenile myoclonic epilepsy

Acar¹,

Dağ²,

Türkel³

2013

jecm

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Article HistoryReceived 15 / 04 / 2013 Accepted 10 / 05 / 2013Juvenile myoclonic epilepsy (JME) is a common epileptic syndrome. Before the development of the new antiepileptic drugs (AEDs) after the 1990s, Valproate (VPA) was the first-line treatment in juvenile myoclonic epilepsy. However, the frequent adverse effects and the risk for teratogenicity have resulted in a search for alternative therapies especially in women. Lamotrigine (LTG), topiramate, and levetiracetam, have been used as monotherapy or adjunctive therapy for juvenile myoclonic epilepsy in small patient series. We report a case of a thirty one-years-old female suffered from severe aggravation in myoclonic and generalized tonic-clonic (GTC) seizures after decreasing the lose of VPA and initiating LTG.

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“…Sodium valproate is the first line of medication for JME. According to the researches, in 41-88% of patients seizures were completely controlled by taking sodium valproate (3). 15% of JME patients are resistant to treatment with sodium valproate, and some patients cannot tolerate the complication of this drug such as, hair loss, weight gain, tremor and menstrual disorders (4).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Levetiracetam With Sodium Valproate in Controlling Seizure in Patients Suffering From Juvenile Myoclonic Epilepsy

Kashipazha

Nejad

Sadr

et al. 2014

Jentashapir J Health Res

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Background: Juvenile myoclonic epilepsy is the most common type of generalized idiopathic epilepsy. Sodium valproate is the first line of medications, but has many complications and 15% of patients are resistant to this medicine. This is a lifelong disease and in case of stopping the medication, relapsing of seizures is seen in more than 80% of cases. Objectives: Analysis the effectiveness of these two drugs on controlling patients seizures by comparing them in mono therapy treatment of JME and to represent levetiracetam as a replacement of sodium valproate for first line medication of JME. Patients and Methods:In this study we compared the effectiveness of sodium valproate and levetiracetam for 66 patients having juvenile myoclonic epilepsy and followed them for 6 months. Results: Comparison of mean generalized tonic colonic attacks in two groups with didn't show meaningful differences (P = 0.95) , also, by comparing the mean of myoclonus attacks in patients of two groups before starting study, no meaningful difference was gained (P = 0.71). Conclusions: It became clear at the end of the study that the effectiveness of two drugs were the same and they didn't have any meaningful difference. According to the result gained from this study, levetiracetam is a proper alternative treatment instead of sodium valproate which has appropriate effectiveness along with lower complications.

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Treatment of Juvenile Myoclonic Epilepsy

Cited by 15 publications

References 70 publications

Upper cervical chiropractic care for a 25-year-old woman with myoclonic seizures

Upper cervical chiropractic care for a 25-year-old woman with myoclonic seizures

Lamotrigine induced seizures in juvenile myoclonic epilepsy

Comparison of Levetiracetam With Sodium Valproate in Controlling Seizure in Patients Suffering From Juvenile Myoclonic Epilepsy

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